{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:16:42Z","timestamp":1788495402539,"version":"build-2803163510"},"reference-count":85,"publisher":"The Royal Society","issue":"1879","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","award":["834691"],"award-info":[{"award-number":["834691"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH","award":["PO1 HL62426"],"award-info":[{"award-number":["PO1 HL62426"]}]},{"name":"NIH","award":["RO1HL 158634"],"award-info":[{"award-number":["RO1HL 158634"]}]},{"name":"NIH","award":["RO1HL128468"],"award-info":[{"award-number":["RO1HL128468"]}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Phil. Trans. R. Soc. B"],"published-print":{"date-parts":[[2023,6,19]]},"abstract":"<jats:p>\n                    In this perspective, we discussed emerging data indicating a role for Notch signalling in inherited disorders of the heart failure with focus on hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) linked to variants of genes encoding mutant proteins of the sarcomere. We recently reported an upregulation of elements in the Notch signalling cascade in cardiomyocytes derived from human inducible pluripotent stem cells expressing a TNNT2 variant encoding cardiac troponin T (cTnT-I79N\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    ), which induces hypertrophy, remodelling, abnormalities in excitation\u2013contraction coupling and electrical instabilities (Shafaattalab S\n                    <jats:italic>et al.<\/jats:italic>\n                    2021\n                    <jats:italic>Front<\/jats:italic>\n                    <jats:italic>.<\/jats:italic>\n                    <jats:italic>Cell Dev. Biol<\/jats:italic>\n                    .\n                    <jats:bold>9<\/jats:bold>\n                    , 787581. (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.3389\/fcell.2021.787581\">doi:10.3389\/fcell.2021.787581<\/jats:ext-link>\n                    )). Our search of the literature revealed the novelty of this finding and stimulated us to discuss potential connections between the Notch signalling pathway and familial cardiomyopathies. Our considerations focused on the potential role of these interactions in arrhythmias, microvascular ischaemia, and fibrosis. This finding underscored a need to consider the role of Notch signalling in familial cardiomyopathies which are trigged by sarcomere mutations engaging mechano-signalling pathways for which there is evidence of a role for Notch signalling with crosstalk with Hippo signalling. Our discussion included a role for both cardiac myocytes and non-cardiac myocytes in progression of HCM and DCM.\n                  <\/jats:p>\n                  <jats:p>This article is part of the theme issue \u2018The heartbeat: its molecular basis and physiological mechanisms\u2019.<\/jats:p>","DOI":"10.1098\/rstb.2022.0176","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T02:39:17Z","timestamp":1682908757000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["A perspective on Notch signalling in progression and arrhythmogenesis in familial hypertrophic and dilated cardiomyopathies"],"prefix":"10.1098","volume":"378","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0334-1391","authenticated-orcid":false,"given":"Paulina","family":"Langa","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics and the Center for Cardiovascular Research, Chicago, IL, 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanam","family":"Shafaattalab","sequence":"additional","affiliation":[{"name":"Molecular Biology and Biochemistry; BC Children\u2019s Hospital Research Institute, Vancouver, BC, V5Z 4H4; Simon Fraser University Burnaby, British Columbia, V5A 4H4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul H.","family":"Goldspink","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics and the Center for Cardiovascular Research, Chicago, IL, 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata M.","family":"Wolska","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics and the Center for Cardiovascular Research, Chicago, IL, 60612, USA"},{"name":"Department of Medicine, Division of Cardiology, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelia A.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics and the Center for Cardiovascular Research, Chicago, IL, 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen F.","family":"Tibbits","sequence":"additional","affiliation":[{"name":"Molecular Biology and Biochemistry; BC Children\u2019s Hospital Research Institute, Vancouver, BC, V5Z 4H4; Simon Fraser University Burnaby, British Columbia, V5A 4H4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. John","family":"Solaro","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics and the Center for Cardiovascular Research, Chicago, IL, 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2023,5]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.787581"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.01.014"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.250738"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.174318"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.04.005"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf9739"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.15593"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313374"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14396"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000265233.40455.62"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.006123"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-014-0435-8"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2017.11.006"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-017-9748-y"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1606444113"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000059562.91384.1A"},{"key":"e_1_3_5_18_2","first-page":"3893","article-title":"Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice","volume":"118","author":"Baudenbacher F","year":"2008","unstructured":"Baudenbacher F, Schober T, Pinto JR, Sidorov VY, Hilliard F, Solaro RJ, Potter JD, Knollmann BC. 2008 Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice. 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