{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T01:46:05Z","timestamp":1777167965719,"version":"3.51.4"},"reference-count":43,"publisher":"The Royal Society","issue":"1887","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":750,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":750,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":750,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"name":"London Centre for Neglected Tropical Disease Research"},{"name":"London Centre for Neglected Tropical Disease Research"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Human mobility contributes to the spatial dynamics of many infectious diseases, and understanding these dynamics helps us to determine the most effective ways to intervene and plan surveillance. In this paper, we describe a novel transmission model for the spatial dynamics of hookworm, a parasitic worm which is a common infection across sub-Saharan Africa, East Asia and the Pacific islands. We fit our model, with and without mobility, to data obtained from a sub-county in Kenya, and validate the model's predictions against the decline in prevalence observed over the course of a clustered randomized control trial evaluating methods of administering mass chemotherapy. We find that our model which incorporates human mobility is able to reproduce the observed patterns in decline of prevalence during the TUMIKIA trial, and additionally, that the widespread bounce-back of infection may be possible over many years, depending on the rates of people movement between villages. The results have important implications for the design of mass chemotherapy programmes for the elimination of human helminth transmission.<\/jats:p>\n                  <jats:p>This article is part of the theme issue \u2018Challenges and opportunities in the fight against neglected tropical diseases: a decade from the London Declaration on NTDs\u2019.<\/jats:p>","DOI":"10.1098\/rstb.2022.0273","type":"journal-article","created":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T19:05:40Z","timestamp":1692558340000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["How important is the spatial movement of people in attempts to eliminate the transmission of human helminth infections by mass drug administration?"],"prefix":"10.1098","volume":"378","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-408X","authenticated-orcid":true,"given":"Benjamin S.","family":"Collyer","sequence":"first","affiliation":[{"name":"Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, St Mary's Campus 1 , ,"},{"name":"Imperial College London 1 , ,"},{"name":"London W2 1PG, UK 1 , ,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Truscott","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, St Mary's Campus 1 , ,"},{"name":"Imperial College London 1 , ,"},{"name":"London W2 1PG, UK 1 , ,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles S.","family":"Mwandawiro","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute 2 ,"},{"name":"Nairobi, Kenya 2 ,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sammy M.","family":"Njenga","sequence":"additional","affiliation":[{"name":"Eastern and Southern Africa Centre of International Parasite Control 3 , ,"},{"name":"Kenya Medical Research Institute 3 , ,"},{"name":"Nairobi, Kenya 3 , ,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9528-3175","authenticated-orcid":true,"given":"Roy M.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, St Mary's Campus 1 , ,"},{"name":"Imperial College London 1 , ,"},{"name":"London W2 1PG, UK 1 , ,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"2026010106411431300_RSTB20220273C1","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1098\/rspb.2004.3046","article-title":"Models of foot-and-mouth disease","volume":"272","author":"Keeling","year":"2005","journal-title":"Proc. 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