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Furthermore, there is strong evidence that defects in this pathway create opportunities for diagnostic and therapeutic intervention. In this\n                    <jats:italic>Opinion<\/jats:italic>\n                    piece, we concisely address the role of endo-lysosomal dysfunction in five neurodegenerative diseases and discuss how future research can investigate this intracellular pathway, including extracellular vesicles with a specific focus on exosomes for the identification of novel disease biomarkers.\n                  <\/jats:p>\n                  <jats:p>This article is part of a discussion meeting issue \u2018Understanding the endo-lysosomal network in neurodegeneration\u2019.<\/jats:p>","DOI":"10.1098\/rstb.2022.0387","type":"journal-article","created":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T19:05:18Z","timestamp":1708283118000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Endo-lysosomal dysfunction in neurodegenerative diseases: opinion on current progress and future direction in the use of exosomes as biomarkers"],"prefix":"10.1098","volume":"379","author":[{"given":"Mathieu","family":"Herman","sequence":"first","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA"},{"name":"Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace W.","family":"Randall","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA"},{"name":"Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia L.","family":"Spiegel","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA"},{"name":"Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphina J.","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA"},{"name":"Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9976-2501","authenticated-orcid":true,"given":"Sabrina","family":"Simoes","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA"},{"name":"Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/35096054"},{"key":"e_1_3_8_3_2","article-title":"The complex ultrastructure of the endolysosomal system","volume":"6","author":"Klumperman J","year":"2014","unstructured":"Klumperman J, Raposo G.. 2014 The complex ultrastructure of the endolysosomal system. 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