{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:49:27Z","timestamp":1787986167324,"version":"build-2784847793"},"reference-count":24,"publisher":"The Royal Society","issue":"1894","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Phil. Trans. R. Soc. B"],"published-print":{"date-parts":[[2024,1,15]]},"abstract":"<jats:p>\n                    The epidemiology of\n                    <jats:italic>Strongyloides stercoralis<\/jats:italic>\n                    is briefly reviewed with an emphasis on cross section and longitudinal studies of infection prevalence stratified by age, performance of different diagnostic tools, mass drug administration (MDA) impact and estimates of key population parameters within the complex life cycle of the parasite that determine transmission intensity and response to control measures. The paucity of studies is highlighted, and gaps in current knowledge identified about the population biology of this very prevalent infection in tropical and sub-tropical regions around the world. A stochastic individual based stochastic model is described in part to highlight gaps in knowledge. The impact of repeated MDA is simulated to illustrate some aspects of transmission dynamics of this helminth infection. Specifically, the impact and bounce back times in either the intervals between treatment rounds, or post the cessation of treatment, depend critically on the magnitude of two distinct components of the basic reproductive number\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sub>0<\/jats:sub>\n                    . The absence of data on these key components is highlighted, as is the value of studies of longitudinal cohorts of people in regions of endemic infection post rounds of MDA to record how infection levels bounce back post treatment at individual and population levels of study.\n                  <\/jats:p>\n                  <jats:p>\n                    This article is part of the Theo Murphy meeting issue \u2018\n                    <jats:italic>Strongyloides<\/jats:italic>\n                    : omics to worm-free populations\u2019.\n                  <\/jats:p>","DOI":"10.1098\/rstb.2022.0442","type":"journal-article","created":{"date-parts":[[2023,11,26]],"date-time":"2023-11-26T19:05:15Z","timestamp":1701025515000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["The transmission dynamics of\n                    <i>Strongyloides stercoralis<\/i>\n                    and the impact of mass drug administration"],"prefix":"10.1098","volume":"379","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-408X","authenticated-orcid":true,"given":"Benjamin S.","family":"Collyer","sequence":"first","affiliation":[{"name":"Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, Praed Street, London W2 1PG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9528-3175","authenticated-orcid":true,"given":"Roy","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, Praed Street, London W2 1PG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9060468"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009314"},{"key":"e_1_3_7_4_2","unstructured":"WHO. 2020 Diagnostic methods for the control of strongyloides. See https:\/\/www.who.int\/publications\/i\/item\/9789240016538 (accessed on 25 October 2023)."},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010299"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006943"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-022-05284-w"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed3020053"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-78"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(95)80023-9"},{"key":"e_1_3_7_11_2","volume-title":"Infectious diseases of humans: dynamics and control","author":"Anderson RM","year":"1992","unstructured":"Anderson RM, May RM. 1992 Infectious diseases of humans: dynamics and control. Oxford, UK: Oxford University Press. See https:\/\/global.oup.com\/academic\/product\/infectious-diseases-of-humans-9780198540403?cc=gb&lang=en&."},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004150"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005607"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2018.10.006"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/1753-6405.12360"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1990.00040031747027"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/297557a0"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60561-8"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(85)90087-2"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-7-266"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apar.2016.08.002"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00180-013-0428-3"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/2041-210X.12050"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0025-5564(94)00055-5"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1214\/aoap\/1034625252"}],"container-title":["Philosophical Transactions of the Royal Society B: Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.2022.0442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rstb.2022.0442","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rstb.2022.0442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:25:29Z","timestamp":1778621129000},"score":1,"resource":{"primary":{"URL":"http:\/\/royalsocietypublishing.org\/rstb\/article\/109403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,27]]},"references-count":24,"journal-issue":{"issue":"1894","published-print":{"date-parts":[[2024,1,15]]}},"alternative-id":["10.1098\/rstb.2022.0442"],"URL":"https:\/\/doi.org\/10.1098\/rstb.2022.0442","relation":{},"ISSN":["0962-8436","1471-2970"],"issn-type":[{"value":"0962-8436","type":"print"},{"value":"1471-2970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,27]]},"assertion":[{"value":"2023-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"20220442"}}