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Participants with focal lesions to the bilateral frontal lobe, right insula\/basal ganglia and left medial temporal lobe showed reduced performance relative to individually matched healthy comparisons during the breathing and motor tasks. They also reported significantly higher anxiety during the 60\u00a0bpm regular and irregular breathing trials, with anxiety correlating with difficulty in rapid breathing specifically within this group. This study demonstrates that damage to frontal, temporal or limbic regions is associated with abnormal voluntary respiratory and motor regulation and tachypnoea-related anxiety, highlighting the role of the forebrain in affective and motor responses during breathing.<\/jats:p>\n                  <jats:p>This article is part of the theme issue \u2018Sensing and feeling: an integrative approach to sensory processing and emotional experience\u2019.<\/jats:p>","DOI":"10.1098\/rstb.2023.0251","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T03:06:09Z","timestamp":1721012769000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Sensing, feeling and regulating: investigating the association of focal brain\u00a0damage with voluntary respiratory\u00a0and motor control"],"prefix":"10.1098","volume":"379","author":[{"given":"Henrik","family":"Bischoff","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Stockholm, 10691 Stockholm, Sweden"},{"name":"Department of Psychology, Carl-von-Ossietzky University Oldenburg, 26129 Oldenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Kovach","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Iowa, Iowa City, IA 52242, USA"},{"name":"Department of Neurosurgery, University of Nebraska Medical Center, Omaha, NE 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukbhinder","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Bruss","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Neurology, and Psychiatry, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Tranel","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2124-8585","authenticated-orcid":true,"given":"Sahib S.","family":"Khalsa","sequence":"additional","affiliation":[{"name":"Laureate Institute for Brain Research, Tulsa, OK 74136, USA"},{"name":"Oxley College of Health Sciences, University of Tulsa, Tulsa, OK 74119, USA"},{"name":"Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-819306-8.00001-0"},{"key":"e_1_3_7_3_2","volume-title":"Nunn's applied respiratory physiology","author":"Lumb A","year":"2016","unstructured":"Lumb A . 2016 Nunn's applied respiratory physiology, vol. 8, 8th edn. 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