{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:33:36Z","timestamp":1791923616162,"version":"4.3.4"},"reference-count":43,"publisher":"The Royal Society","issue":"1906","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Canadian Institute for Health Research operating Grants"},{"name":"MEXT KAKENHI Grant"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Phil. Trans. R. Soc. B"],"published-print":{"date-parts":[[2024,7,29]]},"abstract":"<jats:p>Nitric oxide (NO) is a key diffusible messenger in the mammalian brain. It has been proposed that NO may diffuse retrogradely into presynaptic terminals, contributing to the induction of hippocampal long-term potentiation (LTP). Here, we present novel evidence that NO is required for kainate receptor (KAR)-dependent presynaptic form of LTP (pre-LTP) in the adult insular cortex (IC). In the IC, we found that inhibition of NO synthase erased the maintenance of pre-LTP, while the induction of pre-LTP required the activation of KAR. Furthermore, NO is essential for pre-LTP induced between two pyramidal cells in the IC using the double patch-clamp recording. These results suggest that NO is required for homosynaptic pre-LTP in the IC. Our results present strong evidence for the critical roles of NO in pre-LTP in the IC.<\/jats:p>\n                  <jats:p>This article is part of a discussion meeting issue \u2018Long-term potentiation: 50 years on\u2019.<\/jats:p>","DOI":"10.1098\/rstb.2023.0475","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T03:05:53Z","timestamp":1717988753000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Cortical nitric oxide required for presynaptic long-term potentiation in the insular cortex"],"prefix":"10.1098","volume":"379","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9416-3393","authenticated-orcid":true,"given":"Kiyofumi","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai , Chiyoda-ku, Tokyo 101-8310, Japan"},{"name":"Department of Physiology, Faculty of Medicine, 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5576-5012","authenticated-orcid":true,"given":"Zhaoxiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King's College Circle , Toronto, Ontario M5S 1A8, Canada"},{"name":"Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University , Guangzhou 510130, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6584-0954","authenticated-orcid":true,"given":"Masayuki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai , Chiyoda-ku, Tokyo 101-8310, 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