{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:34:46Z","timestamp":1777865686269,"version":"3.51.4"},"reference-count":29,"publisher":"The Royal Society","issue":"1949","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015691","name":"Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instituto Todos pela Sa\u00fade"},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Science and Technology in Dengue and Host-Microorganism Interactions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chikungunya infection is caused by the Chikungunya alpha virus. The disease is characterized by an acute febrile illness that evolves to chronic, often severe, polyarticular limb arthralgia in approximately 30% of patients. There are no specific treatments for Chikungunya. To characterize the dynamics of viraemia in order to plan future antiviral studies, we took daily blood samples and evaluated serial viral densities measured by RT-PCR in a cohort of 19 adult Brazilian patients with acute Chikungunya infection. Viraemia exhibited a rapid decline, and most individuals were RT-PCR negative by day 4 after study entry. Higher viral loads were associated with earlier clinical presentations. Concentrations of sTNFR1 closely followed the decline in Chikungunya viral loads. Viral clearance measurements may be useful for the development and evaluation of novel treatments for Chikungunya infection.<\/jats:p>\n                  <jats:p>This article is part of the Theo Murphy meeting issue \u2018Evaluating anti-infective drugs\u2019.<\/jats:p>","DOI":"10.1098\/rstb.2024.0352","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:15:44Z","timestamp":1777533344000},"source":"Crossref","is-referenced-by-count":0,"title":["Blood viral density dynamics in acute Chikungunya virus infection"],"prefix":"10.1098","volume":"381","author":[{"given":"Eduardo C.","family":"Souza-Lima","sequence":"first","affiliation":[{"name":"Universidade Federal de Minas Gerais 1 , , ,","place":["Belo Horizonte, Minas Gerais, Brazil"],"department":["Centro de Terapias Avan\u00e7adas e Inovadoras"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renan P.","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais 2 , , ,","place":["Belo Horizonte, Minas Gerais, Brazil"],"department":["Department of Genetics and Evolution"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o V. R.","family":"Dutra","sequence":"additional","affiliation":[{"name":"Universidade Federal do Tri\u00e2ngulo Mineiro - Campus Universit\u00e1rio de Iturama 3 , , ,","place":["Iturama, Minas Gerais, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando R.","family":"Ascencao","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais 1 , , ,","place":["Belo Horizonte, Minas Gerais, Brazil"],"department":["Centro de Terapias Avan\u00e7adas e Inovadoras"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H. K.","family":"Schilling","sequence":"additional","affiliation":[{"name":"Centre for Clinical Vaccinology and Tropical Medicine 4 , ,","place":["Oxford, UK"],"department":["Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J.","family":"White","sequence":"additional","affiliation":[{"name":"Centre for Clinical Vaccinology and Tropical Medicine 4 , ,","place":["Oxford, UK"],"department":["Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato S.","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais 2 , , ,","place":["Belo Horizonte, Minas Gerais, Brazil"],"department":["Department of Genetics and Evolution"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6944-3008","authenticated-orcid":false,"given":"Mauro M.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais 1 , , ,","place":["Belo Horizonte, Minas Gerais, Brazil"],"department":["Centro de Terapias Avan\u00e7adas e Inovadoras"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"2026043003153637100_R1","volume-title":"Chikungunya fever","author":"Ojeda Rodriguez","year":"2025"},{"key":"2026043003153637100_R2","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1007\/s10096-018-3353-0","article-title":"Prevalence and risk factors of post chikungunya rheumatic musculoskeletal disorders: a prospective follow-up study in French Guiana","volume":"37","author":"Bonifay","year":"2018","journal-title":"Eur. 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