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B"],"published-print":{"date-parts":[[2025,11,6]]},"abstract":"<jats:p>\n                    In this introduction, we summarize the research papers, review articles, opinion pieces and important aspects of the facilitated discussion from the meeting \u2018The indirect effects of cytomegalovirus infection: mechanisms and consequences\n                    <jats:italic toggle=\"yes\">\u2019<\/jats:italic>\n                    held at the Royal Society, London, on 14\u201315 October 2024. The term \u2018indirect effects\u2019 describes a statistical excess of pathologies seen in people with human cytomegalovirus (CMV) in the absence of histopathological hallmarks of direct CMV tissue damage. This meeting brought together laboratory scientists, paediatric and adult clinical academics, epidemiologists, and trialists, to discuss the latest research on indirect effects, from biological mechanisms to potential clinical consequences. Important questions regarding the impact of CMV remain unanswered in areas important to human health, such as preterm birth and fetal growth restriction, asymptomatic congenital infection, susceptibility to non-CMV infections, cardiovascular and respiratory disease, transplant, cancer and mental health. Further research is needed to better describe the biology and, critically, to robustly quantify its clinical impact and develop interventions to mitigate any harms.\n                  <\/jats:p>\n                  <jats:p>\n                    This article is part of the discussion meeting issue \u2018The indirect effects of cytomegalovirus infection: mechanisms and consequences\n                    <jats:italic toggle=\"yes\">\u2019<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1098\/rstb.2024.0398","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T08:08:23Z","timestamp":1762416503000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The indirect effects of cytomegalovirus infection\u2014mechanisms and consequences"],"prefix":"10.1098","volume":"380","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6081-1767","authenticated-orcid":true,"given":"Tom A.","family":"Yates","sequence":"first","affiliation":[{"name":"Institute of Health Informatics, University College London, London NW1 2DA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7083-9384","authenticated-orcid":true,"given":"Helen","family":"Payne","sequence":"additional","affiliation":[{"name":"Paediatric Infectious Disease, Imperial College London, London SW7 2AZ, UK"},{"name":"Division of Immunology, Stellenbosch University, Stellenbosch 7599, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9407-1974","authenticated-orcid":true,"given":"Blair L.","family":"Strang","sequence":"additional","affiliation":[{"name":"City St George's University of London, London SW17 0RE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/vez015"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-015-0416-z"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2221797120"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.20736"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2034"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03420240121038"},{"key":"e_1_3_8_8_2","unstructured":"Yates T Payne H Strang B. 2025 Supplementary material from: The indirect effects of cytomegalovirus infection\u2014mechanisms and consequences. 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