{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T19:45:53Z","timestamp":1787946353896,"version":"build-2784847793"},"reference-count":270,"publisher":"The Royal Society","issue":"1957","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004376","name":"Terry Fox Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004376","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Edwin S.H. 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As such, we also outline how oncogenic mutations in histologically normal tissue may predispose cells to malignant transformations promoted by environmental exposures. Finally, we consider strategies to mitigate the risk of pollution-promoted lung cancer in vulnerable populations and provide future directions for research aimed at precision prevention of lung cancer.<\/jats:p>\n                  <jats:p>This article is part of the discussion meeting issue \u2018Epidermal growth factor receptor after 40 years\u2019.<\/jats:p>","DOI":"10.1098\/rstb.2024.0508","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T07:09:45Z","timestamp":1787814585000},"source":"Crossref","is-referenced-by-count":1,"title":["Epidermal growth factor receptor dysregulation and climate change: insights into pollution-promoted lung cancer"],"prefix":"10.1098","volume":"381","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8131-8179","authenticated-orcid":false,"given":"Taysia","family":"Nikaido-Landry","sequence":"first","affiliation":[{"name":"Biochemistry and Molecular Biology, The University of British Columbia 1 , Vancouver, British Columbia V6T 1Z3, Canada"},{"name":"Bioinformatics Graduate Program, The University of British Columbia 2 , Vancouver, British Columbia V6T 1Z3, Canada"},{"name":"Edwin SH Leong Centre for Healthy Aging 4 , British Columbia V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0021-575X","authenticated-orcid":false,"given":"Yujia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology, The University of British Columbia 1 , Vancouver, British Columbia V6T 1Z3, Canada"},{"name":"Department of Microbiology and Immunology, The University of British Columbia 3 , Vancouver, British Columbia V6T 1Z3, Canada"},{"name":"Edwin SH Leong Centre for Healthy Aging 4 , British Columbia V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2954-1795","authenticated-orcid":false,"given":"Emilia L.","family":"Lim","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology, The University of British Columbia 1 , Vancouver, British Columbia V6T 1Z3, Canada"},{"name":"Edwin SH Leong Centre for Healthy Aging 4 , British Columbia V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"2026082703094063400_RSTB20240508C1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0092-8674(90)90186-I","article-title":"A genetic model for colorectal tumorigenesis","volume":"61","author":"Fearon","year":"1990","journal-title":"Cell"},{"key":"2026082703094063400_RSTB20240508C2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41568-021-00335-3","article-title":"Clonal expansion in non-cancer tissues","volume":"21","author":"Kakiuchi","year":"2021","journal-title":"Nat. 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