{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T08:02:39Z","timestamp":1770710559988,"version":"3.49.0"},"reference-count":42,"publisher":"The Royal Society","issue":"1941","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>As part of a larger community-based epidemiological study entitled Hybridisation in Uro-Genital Schistosomiasis (HUGS), a parasite infection and clinical morbidity sub-study, implementing portable ultrasonography annually, was undertaken upon 701 participants from two communities in Mangochi and Nsanje Districts, southern Malawi. Our aim was to document the clinical morbidity a year after praziquantel treatment in those with previously proven human and\/or zoonotic schistosomiasis, repeated a calendar year later after biannual praziquantel treatment. The median participant age was 12.0 years, with 293 (41.8%) having urinary Schistosoma haematobium egg-patent infections. Upon molecular analyses, these participants were co-infected with S. mansoni (29, 9.9%), S. mattheei (38, 13.0%), and six were infected with all three schistosome species occurring concurrently. A total of 166 participants (23.7%) had abnormal bladder wall thickness, 72 severely abnormal thickened bladder walls and 7 had bladder wall masses, among other abnormalities by ultrasonography. On the second annual follow-up, 203 participants were available (median age: 22.0 years), and of these, 27 (13.3%) presented with urinary S. haematobium egg-patent infections, with 2 (1.0%) having Schistosoma mansoni, 8 (3.9%) having Schistosoma mattheei and 2 with all species concurrently. Of these, only six participants (3.0%) had severely abnormal thickened bladder walls and other abnormalities. Overall, greater morbidity was observed in those with S. haematobium alone than in those with mixed species infections.<\/jats:p>\n                  <jats:p>\u2019This article is part of the Science+ meeting issue \u2018Parasite evolution and impact in action: exploring the importance and control of hybrid schistosomes\u2019.<\/jats:p>","DOI":"10.1098\/rstb.2024.0524","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:40:50Z","timestamp":1767865250000},"source":"Crossref","is-referenced-by-count":1,"title":["Clinical morbidity of single or mixed schistosome species infection in two communities of southern Malawi"],"prefix":"10.1098","volume":"381","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6948-0087","authenticated-orcid":false,"given":"Sekeleghe A.","family":"Kayuni","sequence":"first","affiliation":[{"name":"Malawi-Liverpool-Wellcome Research Programme 1 , , ,","place":["Blantyre, Southern Region, Malawi, 312200"]},{"name":"Liverpool 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