{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:09:45Z","timestamp":1792786185569,"version":"4.5.0"},"reference-count":50,"publisher":"The Royal Society","issue":"1960","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100003896","name":"Henry M. Jackson Foundation for the Advancement of Military Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003896","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003240","name":"Passano Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003240","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Neurocritical Care Society","id":[{"id":"https:\/\/ror.org\/041d0cg91","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005339","name":"American Academy of Neurology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005339","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Burroughs-Wellcome Scholar-AHEAD Program"},{"name":"GEn1E Lifesciences"},{"DOI":"10.13039\/100000065","name":"NIH\/National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS115815"],"award-info":[{"award-number":["R01NS115815"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NIH\/National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21NS131689"],"award-info":[{"award-number":["R21NS131689"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chuck Noll Foundation","id":[{"id":"https:\/\/ror.org\/02wkjgb27","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009797","name":"Barrow Neurological Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009797","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Traumatic brain injury (TBI) triggers competing damage and repair processes that can result in chronic neurodegenerative protein conformational disorders. Acute alterations in proteostasis have been reported after injury, but a comprehensive understanding of changes to the proteostasis network (PN) has been limited by the complex cellular pathology of TBI. The recent enumeration of the human PN and advances in single-cell transcriptomics make it possible to delineate PN dynamics in multifactorial diseases such as TBI. Here, we leverage archival mouse and human transcriptomic data to identify cell-type-specific Sub-PNs in the brain and their alteration by TBI. We find characteristic PN gene expression profiles in many cell types and subtypes, reflecting tremendous diversity in the enrichment of specific PN processes. TBI induces a broad transcriptional remodelling of translation, the ubiquitin\u2013proteasome system and nuclear proteostasis machinery across cell types. In addition to this shared response, numerous cell-type-specific responses occur, some of which are conserved between mouse and human, despite differences in injury mechanism and timing. Our extensive characterization of the PN transcriptome across cell type and disease reveals potentially modifiable mechanisms of PN alteration in TBI. More broadly, our results provide a framework for elucidating changes to the PN in complex diseases.<\/jats:p>\n                  <jats:p>This article is part of the Theo Murphy meeting issue \u2018ProteostaSys: a systems view of proteostasis\u2019.<\/jats:p>","DOI":"10.1098\/rstb.2025.0264","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:06:54Z","timestamp":1790838414000},"source":"Crossref","is-referenced-by-count":0,"title":["Traumatic brain injury induces cell-type-specific remodelling of the proteostasis network"],"prefix":"10.1098","volume":"381","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9465-3333","authenticated-orcid":false,"given":"Jonathan","family":"Lefkowitz","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Maryland School of Medicine 1 , Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milo","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Maryland School of Medicine 1 , Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Kumar","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Barrow Neurological Institute 2 , Phoenix, AZ, USA"},{"name":"Department of Neurological Surgery, Barrow Neurological Institute 3 , Phoenix, AZ, USA"},{"name":"Department of Translational Neuroscience, Barrow Neurological Institute 4 , Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchira M.","family":"Jha","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Barrow Neurological Institute 2 , Phoenix, AZ, USA"},{"name":"Department of Neurological Surgery, Barrow Neurological Institute 3 , Phoenix, AZ, USA"},{"name":"Department of Translational Neuroscience, Barrow Neurological Institute 4 , Phoenix, AZ, USA"},{"name":"Safar Center for Resuscitation Research, UPMC Children's Hospital of Pittsburgh, School of Medicine, University of Pittsburgh 5 , Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhivyaa","family":"Rajasundaram","sequence":"additional","affiliation":[{"name":"Division of Health Informatics, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, School of Medicine, University of Pittsburgh 6 , Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1445-0577","authenticated-orcid":false,"given":"Prajwal","family":"Ciryam","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Maryland School of Medicine 1 , Baltimore, MD, USA"},{"name":"Shock Trauma Neurocritical Care, Program in Trauma, R Adams Cowley Shock Trauma Center, University of Maryland Medical Center 7 , Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"2026100103064140700_RSTB20250264C1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1474-4422(18)30499-X","article-title":"Global, regional, and national burden of neurological disorders, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"Feigin","year":"2019","journal-title":"Lancet Neurol."},{"key":"2026100103064140700_RSTB20250264C2","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.neuron.2017.07.010","article-title":"Neuroimmunology of traumatic brain injury: time for a paradigm shift","volume":"95","author":"Jassam","year":"2017","journal-title":"Neuron"},{"key":"2026100103064140700_RSTB20250264C3","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.biopsych.2021.05.025","article-title":"Traumatic brain injury and risk of neurodegenerative disorder","volume":"91","author":"Brett","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"2026100103064140700_RSTB20250264C4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13024-025-00842-z","article-title":"Cellular and molecular mechanisms of pathological tau phosphorylation in traumatic brain injury: implications for chronic traumatic encephalopathy","volume":"20","author":"Donison","year":"2025","journal-title":"Mol. Neurodegener."},{"key":"2026100103064140700_RSTB20250264C5","doi-asserted-by":"crossref","first-page":"149873","DOI":"10.1016\/j.brainres.2025.149873","article-title":"Traumatic brain injury and neurodegenerative diseases: the role of axonal injury and amyloid-\u03b2","volume":"1865","author":"Bi","year":"2025","journal-title":"Brain Res."},{"key":"2026100103064140700_RSTB20250264C6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mcn.2015.03.001","article-title":"Epidemiology of mild traumatic brain injury and neurodegenerative disease","volume":"66","author":"Gardner","year":"2015","journal-title":"Mol. Cell. Neurosci."},{"key":"2026100103064140700_RSTB20250264C7","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/sj.jcbfm.9600587","article-title":"Changes in autophagy after traumatic brain injury","volume":"28","author":"Liu","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"2026100103064140700_RSTB20250264C8","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.tins.2021.06.003","article-title":"Synergistic effects of brain injury and aging: common mechanisms of proteostatic dysfunction","volume":"44","author":"Saikumar","year":"2021","journal-title":"Trends Neurosci."},{"key":"2026100103064140700_RSTB20250264C9","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1523\/JNEUROSCI.1756-17.2018","article-title":"Endoplasmic reticulum stress contributes to the loss of newborn hippocampal neurons after traumatic brain injury","volume":"38","author":"Hood","year":"2018","journal-title":"J. Neurosci."},{"key":"2026100103064140700_RSTB20250264C10","doi-asserted-by":"crossref","first-page":"827","DOI":"10.4103\/1673-5374.232477","article-title":"Inhibition of endoplasmic reticulum stress alleviates secondary injury after traumatic brain injury","volume":"13","author":"Tan","year":"2018","journal-title":"Neural Regener. Res."},{"key":"2026100103064140700_RSTB20250264C11","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.freeradbiomed.2008.04.038","article-title":"Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury","volume":"45","author":"Ansari","year":"2008","journal-title":"Free Radical Biol. Med."},{"key":"2026100103064140700_RSTB20250264C12","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1111\/j.1471-4159.2007.04489.x","article-title":"Mitochondrial dysfunction early after traumatic brain injury in immature rats","volume":"101","author":"Robertson","year":"2007","journal-title":"J. Neurochem."},{"key":"2026100103064140700_RSTB20250264C13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1089\/neu.1997.14.23","article-title":"Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury","volume":"14","author":"Xiong","year":"1997","journal-title":"J. Neurotrauma"},{"key":"2026100103064140700_RSTB20250264C14","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1089\/neu.1999.16.471","article-title":"Expression of brain-derived neurotrophic factor, nerve growth factor, and heat shock protein HSP70 following fluid percussion brain injury in rats","volume":"16","author":"Truettner","year":"1999","journal-title":"J. Neurotrauma"},{"key":"2026100103064140700_RSTB20250264C15","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1089\/neu.2006.0186","article-title":"Subcellular stress response after traumatic brain injury","volume":"24","author":"Truettner","year":"2007","journal-title":"J. Neurotrauma"},{"key":"2026100103064140700_RSTB20250264C16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1089\/neu.1998.15.411","article-title":"Patterns of heat-shock protein 70 biosynthesis following human traumatic brain injury","volume":"15","author":"Dutcher","year":"1998","journal-title":"J. Neurotrauma"},{"key":"2026100103064140700_RSTB20250264C17","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.brainres.2007.08.076","article-title":"Ubiquitin and ubiquitin-conjugated protein expression in the rat cerebral cortex and hippocampus following traumatic brain injury (TBI)","volume":"1182","author":"Yao","year":"2007","journal-title":"Brain Res."},{"key":"2026100103064140700_RSTB20250264C18","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.neuroscience.2014.11.010","article-title":"Pharmacological induction of the 70-kDa heat shock protein protects against brain injury","volume":"284","author":"Kim","year":"2015","journal-title":"Neuroscience"},{"key":"2026100103064140700_RSTB20250264C19","article-title":"A comprehensive enumeration of the human proteostasis network. 1. Components of translation, protein folding, and organelle-specific systems","author":"Consortium","year":"2022","journal-title":"bioRxiv"},{"key":"2026100103064140700_RSTB20250264C20","article-title":"A comprehensive enumeration of the human proteostasis network. 2. Components of the autophagy\u2013lysosome pathway","author":"Elsasser","year":"2023","journal-title":"bioRxiv"},{"key":"2026100103064140700_RSTB20250264C21","doi-asserted-by":"crossref","first-page":"230386","DOI":"10.1098\/rsob.230386","article-title":"Single-cell expression predicts neuron-specific protein homeostasis networks","volume":"14","author":"Pechmann","year":"2024","journal-title":"Open Biol."},{"key":"2026100103064140700_RSTB20250264C22","doi-asserted-by":"crossref","first-page":"e1013155","DOI":"10.1371\/journal.pcbi.1013155","article-title":"Proteostasis signatures in human diseases","volume":"21","author":"Lim","year":"2025","journal-title":"PLoS Comput. Biol."},{"key":"2026100103064140700_RSTB20250264C23","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2026100103064140700_RSTB20250264C24","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1089\/neu.1999.16.1023","article-title":"Prolonged activation of NF-\u03bab following traumatic brain injury in rats","volume":"16","author":"Nonaka","year":"1999","journal-title":"J. Neurotrauma"},{"key":"2026100103064140700_RSTB20250264C25","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1089\/neu.2013.3169","article-title":"Activation of NF-\u03bab mediates astrocyte swelling and brain edema in traumatic brain injury","volume":"31","author":"Jayakumar","year":"2014","journal-title":"J. Neurotrauma"},{"key":"2026100103064140700_RSTB20250264C26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1089\/neu.1994.11.265","article-title":"Bioenergetic analysis of oxidative metabolism following traumatic brain injury in rats","volume":"11","author":"Vink","year":"1994","journal-title":"J. Neurotrauma"},{"key":"2026100103064140700_RSTB20250264C27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.freeradbiomed.2023.02.001","article-title":"Comprehensive evaluation of mitochondrial redox profile, calcium dynamics, membrane integrity and apoptosis markers in a preclinical model of severe penetrating traumatic brain injury","volume":"198","author":"Pandya","year":"2023","journal-title":"Free Radical Biol. Med."},{"key":"2026100103064140700_RSTB20250264C28","doi-asserted-by":"crossref","first-page":"9459","DOI":"10.1523\/JNEUROSCI.23-28-09459.2003","article-title":"Complement activation contributes to hypoxic-ischemic brain injury in neonatal rats","volume":"23","author":"Cowell","year":"2003","journal-title":"J. Neurosci."},{"key":"2026100103064140700_RSTB20250264C29","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1177\/0271678X18758881","article-title":"Human brain trauma severity is associated with lectin complement pathway activation","volume":"39","author":"De Blasio","year":"2019","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"2026100103064140700_RSTB20250264C30","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/TA.0b013e318190c3c0","article-title":"Coagulopathy in severe traumatic brain injury: a prospective study","volume":"66","author":"Talving","year":"2009","journal-title":"J. Trauma Acute Care Surg."},{"key":"2026100103064140700_RSTB20250264C31","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1089\/neu.2014.3694","article-title":"Chaperone-mediated autophagy after traumatic brain injury","volume":"32","author":"Park","year":"2015","journal-title":"J. Neurotrauma"},{"key":"2026100103064140700_RSTB20250264C32","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.4161\/15548627.2014.981787","article-title":"Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury","volume":"10","author":"Sarkar","year":"2014","journal-title":"Autophagy"},{"key":"2026100103064140700_RSTB20250264C33","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1016\/j.neuron.2024.06.021","article-title":"A single-cell atlas deconstructs heterogeneity across multiple models in murine traumatic brain injury and identifies novel cell-specific targets","volume":"112","author":"Jha","year":"2024","journal-title":"Neuron"},{"key":"2026100103064140700_RSTB20250264C34","doi-asserted-by":"crossref","first-page":"113395","DOI":"10.1016\/j.celrep.2023.113395","article-title":"Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia","volume":"42","author":"Garza","year":"2023","journal-title":"Cell Rep."},{"key":"2026100103064140700_RSTB20250264C35","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1038\/s41593-024-01764-7","article-title":"A cross-disease resource of living human microglia identifies disease-enriched subsets and tool compounds recapitulating microglial states","volume":"27","author":"Tuddenham","year":"2024","journal-title":"Nat. Neurosci."},{"key":"2026100103064140700_RSTB20250264C36","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41420-024-01913-8","article-title":"N4BP1 functions as a dimerization-dependent linear ubiquitin reader which regulates TNF signalling","volume":"10","author":"Kliza","year":"2024","journal-title":"Cell Death Discov."},{"key":"2026100103064140700_RSTB20250264C37","doi-asserted-by":"crossref","first-page":"107954","DOI":"10.1016\/j.jbc.2024.107954","article-title":"The NEDD4-binding protein N4BP1 degrades mRNA substrates through the coding sequence independent of nonsense-mediated decay","volume":"300","author":"Zheng","year":"2024","journal-title":"J. Biol. Chem."},{"key":"2026100103064140700_RSTB20250264C38","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S1474-4422(18)30231-X","article-title":"Serum GFAP and UCH-L1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI): a multicentre observational study","volume":"17","author":"Bazarian","year":"2018","journal-title":"Lancet Neurol."},{"key":"2026100103064140700_RSTB20250264C39","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1038\/s41467-018-06222-0","article-title":"Single cell molecular alterations reveal target cells and pathways of concussive brain injury","volume":"9","author":"Arneson","year":"2018","journal-title":"Nat. Commun."},{"key":"2026100103064140700_RSTB20250264C40","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1083\/jcb.201612111","article-title":"Shaping proteostasis at the cellular, tissue, and organismal level","volume":"216","author":"Sala","year":"2017","journal-title":"J. Cell Biol."},{"key":"2026100103064140700_RSTB20250264C41","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nn.4366","article-title":"Disentangling neural cell diversity using single-cell transcriptomics","volume":"19","author":"Poulin","year":"2016","journal-title":"Nat. Neurosci."},{"key":"2026100103064140700_RSTB20250264C42","doi-asserted-by":"crossref","first-page":"803244","DOI":"10.3389\/fimmu.2021.803244","article-title":"Alpha-2-macroglobulin in inflammation, immunity and infections","volume":"12","author":"Vandooren","year":"2021","journal-title":"Front. Immunol."},{"key":"2026100103064140700_RSTB20250264C43","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1038\/jcbfm.2013.146","article-title":"Microglia\/macrophage polarization dynamics in white matter after traumatic brain injury","volume":"33","author":"Wang","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"2026100103064140700_RSTB20250264C44","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13059-020-02257-z","article-title":"Evolutionary conservation and divergence of the human brain transcriptome","volume":"22","author":"Pembroke","year":"2021","journal-title":"Genome Biol."},{"key":"2026100103064140700_RSTB20250264C45","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"2026100103064140700_RSTB20250264C46","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/nprot.2009.97","article-title":"Mapping identifiers for the integration of genomic datasets with the R\/bioconductor package biomaRt","volume":"4","author":"Durinck","year":"2009","journal-title":"Nat. Protoc."},{"key":"2026100103064140700_RSTB20250264C47","doi-asserted-by":"crossref","first-page":"giy083","DOI":"10.1093\/gigascience\/giy083","article-title":"Clustering trees: a visualization for evaluating clusterings at multiple resolutions","volume":"7","author":"Zappia","year":"2018","journal-title":"Gigascience"},{"key":"2026100103064140700_RSTB20250264C48","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1093\/nar\/gkab481","article-title":"Cell type hierarchy reconstruction via reconciliation of multi-resolution cluster tree","volume":"49","author":"Peng","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2026100103064140700_RSTB20250264C49","first-page":"060012","article-title":"Fast gene set enrichment analysis","author":"Korotkevich","year":"2016","journal-title":"bioRxiv"},{"key":"2026100103064140700_RSTB20250264C50","article-title":"Supplementary material from: Traumatic brain injury induces cell-type-specific remodelling of the proteostasis network","author":"Lefkowitz","year":"2026"}],"container-title":["Philosophical Transactions of the Royal Society B: Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article-pdf\/doi\/10.1098\/rstb.2025.0264\/6168572\/rstb.2025.0264.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article-pdf\/doi\/10.1098\/rstb.2025.0264\/6168572\/rstb.2025.0264.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:07:01Z","timestamp":1790838421000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article\/381\/1960\/20250264\/483482\/Traumatic-brain-injury-induces-cell-type-specific"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":50,"journal-issue":{"issue":"1960","published-online":{"date-parts":[[2026,10,1]]},"published-print":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.1098\/rstb.2025.0264","relation":{},"ISSN":["0962-8436","1471-2970"],"issn-type":[{"value":"0962-8436","type":"print"},{"value":"1471-2970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"article-number":"20250264"}}