{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:57:02Z","timestamp":1790841422279,"version":"4.1.0"},"reference-count":237,"publisher":"The Royal Society","issue":"1960","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000965","name":"American Federation for Aging Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000965","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001642","name":"Glenn Foundation for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Disruption of protein homoeostasis, or proteostasis, is a hallmark of protein conformational diseases (PCDs), including Alzheimer's and Parkinson's disease. These disorders are characterized by progressive protein aggregation and cellular dysfunction, yet no effective therapies exist. Emerging evidence indicates that microbial communities influence host proteostasis, giving rise to the concept of the microbiota\u2013proteostasis axis. Microbes and their products can modulate host proteins by engaging with host proteostasis. As such, microbial dysbiosis has been linked to proteostasis disruption through the production of metabolites, extracellular vesicles, functional amyloids, and toxins or effector proteins capable of seeding or destabilizing host proteins associated with PCDs. These microbial factors have been shown in experimental models to converge on key proteostasis pathways, including protein synthesis, folding and clearance, thereby potentially reducing cellular buffering capacity and lowering the threshold for proteotoxic collapse. In parallel, microbiota-driven influence on inflammatory responses and immune signalling further amplifies systemic proteostasis disruption. In this review, we synthesize emerging evidence defining the microbiota\u2013proteostasis axis and highlight how microbial factors influence host proteostasis. Importantly, these host\u2013microbe interactions often precede neurodegeneration, suggesting potential for early detection and intervention. Together, these insights support targeting the microbiota as a potential strategy to enhance proteostasis and delay or prevent neurodegenerative disease.<\/jats:p>\n                  <jats:p>This article is part of the Theo Murphy meeting issue \u2018ProteostaSys: a systems view of proteostasis\u2019.<\/jats:p>","DOI":"10.1098\/rstb.2025.0265","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:07:05Z","timestamp":1790838425000},"source":"Crossref","is-referenced-by-count":0,"title":["The microbiota\u2013proteostasis axis: implications in neurodegenerative diseases"],"prefix":"10.1098","volume":"381","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7491-5292","authenticated-orcid":false,"given":"Daniel M.","family":"Czy\u017c","sequence":"first","affiliation":[{"name":"Department of Microbiology, Institute of Food and Agricultural Sciences, University of Florida 1 , Gainesville FL, USA"},{"name":"McKnight Brain Institute, University of Florida 2 , Gainesville FL, USA"},{"name":"Emerging Pathogens Institute, University of Florida 3 , Gainesville FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittani M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Food and Agricultural Sciences, University of Florida 1 , Gainesville FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"2026100103065479100_RSTB20250265C1","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/s41593-018-0235-9","article-title":"Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases","volume":"21","author":"Soto","year":"2018","journal-title":"Nat. Neurosci."},{"key":"2026100103065479100_RSTB20250265C2","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1126\/science.1141448","article-title":"Adapting proteostasis for disease intervention","volume":"319","author":"Balch","year":"2008","journal-title":"Science"},{"key":"2026100103065479100_RSTB20250265C3","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a risk factor for neurodegenerative disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"2026100103065479100_RSTB20250265C4","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1172\/JCI24761","article-title":"The genetic epidemiology of neurodegenerative disease","volume":"115","author":"Bertram","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2026100103065479100_RSTB20250265C5","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fncel.2015.00124","article-title":"Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases","volume":"9","author":"Chin-Chan","year":"2015","journal-title":"Front Cell Neurosci."},{"key":"2026100103065479100_RSTB20250265C6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson's disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"2026100103065479100_RSTB20250265C7","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00401-014-1343-6","article-title":"Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats","volume":"128","author":"Holmqvist","year":"2014","journal-title":"Acta Neuropathol."},{"key":"2026100103065479100_RSTB20250265C8","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.neuron.2019.05.035","article-title":"Transneuronal propagation of pathologic \u03b1-synuclein from the gut to the brain models Parkinson's disease","volume":"103","author":"Kim","year":"2019","journal-title":"Neuron"},{"key":"2026100103065479100_RSTB20250265C9","doi-asserted-by":"crossref","first-page":"e00437","DOI":"10.1128\/iai.00437-22","article-title":"Oh my gut! is the microbial origin of neurodegenerative diseases real?","volume":"91","author":"Walker","year":"2023","journal-title":"Infect. Immun."},{"key":"2026100103065479100_RSTB20250265C10","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1126\/science.1124234","article-title":"Metagenomic analysis of the human distal gut microbiome","volume":"312","author":"Gill","year":"2006","journal-title":"Science"},{"key":"2026100103065479100_RSTB20250265C11","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nm.4517","article-title":"Current understanding of the human microbiome","volume":"24","author":"Gilbert","year":"2018","journal-title":"Nat. Med."},{"key":"2026100103065479100_RSTB20250265C12","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"2026100103065479100_RSTB20250265C13","doi-asserted-by":"crossref","first-page":"e1009510","DOI":"10.1371\/journal.ppat.1009510","article-title":"Colonization of the Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate","volume":"17","author":"Walker","year":"2021","journal-title":"PLoS Pathog."},{"key":"2026100103065479100_RSTB20250265C14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/14737175.2018.1400909","article-title":"Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer's disease-type beta-amyloid neuropathological mechanisms","volume":"18","author":"Ho","year":"2018","journal-title":"Expert Rev. Neurother."},{"key":"2026100103065479100_RSTB20250265C15","doi-asserted-by":"crossref","first-page":"102165","DOI":"10.1016\/j.redox.2021.102165","article-title":"Short-chain fatty acids as modulators of redox signaling in health and disease","volume":"47","author":"Gonz\u00e1lez-Bosch","year":"2021","journal-title":"Redox Biol."},{"key":"2026100103065479100_RSTB20250265C16","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.3389\/fimmu.2019.01486","article-title":"Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases","volume":"10","author":"Parada Venegas","year":"2019","journal-title":"Front. Immunol."},{"key":"2026100103065479100_RSTB20250265C17","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/febs.17023","article-title":"Microbial amyloids in neurodegenerative amyloid diseases","volume":"292","author":"Sampson","year":"2025","journal-title":"FEBS J."},{"key":"2026100103065479100_RSTB20250265C18","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3390\/microorganisms10030578","article-title":"Gut microbiota dysbiosis: triggers, consequences, diagnostic and therapeutic options","volume":"10","author":"Hrncir","year":"2022","journal-title":"Microorganisms"},{"key":"2026100103065479100_RSTB20250265C19","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1056\/NEJMra1600266","article-title":"The human intestinal microbiome in health and disease","volume":"375","author":"Lynch","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"2026100103065479100_RSTB20250265C20","doi-asserted-by":"crossref","first-page":"102368","DOI":"10.1016\/j.xcrm.2025.102368","article-title":"The multiomics blueprint of the individual with the most extreme lifespan","volume":"6","author":"Santos-Pujol","year":"2025","journal-title":"Cell Rep. Med."},{"key":"2026100103065479100_RSTB20250265C21","doi-asserted-by":"crossref","first-page":"110828","DOI":"10.1016\/j.isci.2024.110828","article-title":"Identification of proteotoxic and proteoprotective bacteria that non-specifically affect proteins associated with neurodegenerative diseases","volume":"27","author":"Walker","year":"2024","journal-title":"iScience"},{"key":"2026100103065479100_RSTB20250265C22","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.3390\/ijms23094807","article-title":"Bacteria-derived protein aggregates contribute to the disruption of host proteostasis","volume":"23","author":"Walker","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2026100103065479100_RSTB20250265C23","doi-asserted-by":"crossref","first-page":"5258","DOI":"10.1038\/s41598-023-31730-5","article-title":"Genetic correlations between Alzheimer's disease and gut microbiome genera","volume":"13","author":"Cammann","year":"2023","journal-title":"Sci. Rep."},{"key":"2026100103065479100_RSTB20250265C24","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/nature02261","article-title":"Protein folding and misfolding","volume":"426","author":"Dobson","year":"2003","journal-title":"Nature"},{"key":"2026100103065479100_RSTB20250265C25","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41392-025-02439-w","article-title":"Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations","volume":"10","author":"Kuzu","year":"2025","journal-title":"Signal Transduction Targeted Ther."},{"key":"2026100103065479100_RSTB20250265C26","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev.biochem.75.101304.123901","article-title":"Protein misfolding, functional amyloid, and human disease","volume":"75","author":"Chiti","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"2026100103065479100_RSTB20250265C27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nature12481","article-title":"Self-propagation of pathogenic protein aggregates in neurodegenerative diseases","volume":"501","author":"Jucker","year":"2013","journal-title":"Nature"},{"key":"2026100103065479100_RSTB20250265C28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrm2101","article-title":"Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide","volume":"8","author":"Haass","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026100103065479100_RSTB20250265C29","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nrm3810","article-title":"The amyloid state and its association with protein misfolding diseases","volume":"15","author":"Knowles","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026100103065479100_RSTB20250265C30","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1093\/gerona\/glu049","article-title":"Proteostasis and the aging proteome in health and disease","volume":"69","author":"Morimoto","year":"2014","journal-title":"J. Gerontol. A: Biol. Sci. Med. Sci."},{"key":"2026100103065479100_RSTB20250265C31","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1038\/nm1066","article-title":"Protein aggregation and neurodegenerative disease","volume":"10","author":"Ross","year":"2004","journal-title":"Nat. Med."},{"key":"2026100103065479100_RSTB20250265C32","doi-asserted-by":"crossref","first-page":"e1003785","DOI":"10.1371\/journal.ppat.1003785","article-title":"Brucella induces an unfolded protein response via TcpB that supports intracellular replication in macrophages","volume":"9","author":"Smith","year":"2013","journal-title":"PLoS Pathog."},{"key":"2026100103065479100_RSTB20250265C33","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.micpath.2009.08.002","article-title":"Inhibition of heat shock protein expression by Helicobacter pylori","volume":"47","author":"Axsen","year":"2009","journal-title":"Microb. Pathog."},{"key":"2026100103065479100_RSTB20250265C34","doi-asserted-by":"crossref","first-page":"100150","DOI":"10.1016\/j.cstres.2026.100150","article-title":"Modulation of host proteostasis by Prevotella corporis via induction of the heat shock response","volume":"31","author":"Tibi","year":"2026","journal-title":"Cell Stress Chaperones"},{"key":"2026100103065479100_RSTB20250265C35","doi-asserted-by":"crossref","first-page":"e1006654","DOI":"10.1371\/journal.ppat.1006654","article-title":"The role of microbial amyloid in neurodegeneration","volume":"13","author":"Friedland","year":"2017","journal-title":"PLoS Pathog."},{"key":"2026100103065479100_RSTB20250265C36","doi-asserted-by":"crossref","first-page":"e1010660","DOI":"10.1371\/journal.ppat.1010660","article-title":"A protein\u2013protein interaction map reveals that the Coxiella burnetii effector CirB inhibits host proteasome activity","volume":"18","author":"Fu","year":"2022","journal-title":"PLoS Pathog."},{"key":"2026100103065479100_RSTB20250265C37","doi-asserted-by":"crossref","first-page":"e12974","DOI":"10.1111\/cmi.12974","article-title":"Shigella effector IpaH4.5 targets 19S regulatory particle subunit RPN13 in the 26S proteasome to dampen cytotoxic T lymphocyte activation","volume":"21","author":"Otsubo","year":"2019","journal-title":"Cell Microbiol."},{"key":"2026100103065479100_RSTB20250265C38","doi-asserted-by":"crossref","first-page":"e1001289","DOI":"10.1371\/journal.ppat.1001289","article-title":"Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila","volume":"7","author":"Fontana","year":"2011","journal-title":"PLoS Pathog."},{"key":"2026100103065479100_RSTB20250265C39","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41392-023-01486-5","article-title":"Role of neuroinflammation in neurodegeneration development","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"2026100103065479100_RSTB20250265C40","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1016\/j.cell.2024.03.034","article-title":"Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway","volume":"187","author":"Nie","year":"2024","journal-title":"Cell"},{"key":"2026100103065479100_RSTB20250265C41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13099-024-00635-7","article-title":"The influence of Akkermansia muciniphila on intestinal barrier function","volume":"16","author":"Mo","year":"2024","journal-title":"Gut Pathog."},{"key":"2026100103065479100_RSTB20250265C42","doi-asserted-by":"crossref","first-page":"1506636","DOI":"10.3389\/fcimb.2025.1506636","article-title":"Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis","volume":"15","author":"Lialios","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"2026100103065479100_RSTB20250265C43","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1242\/jcs.03455","article-title":"Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and gamma-secretase-dependent E-cadherin cleavage","volume":"120","author":"Wu","year":"2007","journal-title":"J. Cell Sci."},{"key":"2026100103065479100_RSTB20250265C44","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.1038\/s41467-023-41283-w","article-title":"Bacteroides fragilis in the gut microbiomes of Alzheimer's disease activates microglia and triggers pathogenesis in neuronal C\/EBP\u03b2 transgenic mice","volume":"14","author":"Xia","year":"2023","journal-title":"Nat. Commun."},{"key":"2026100103065479100_RSTB20250265C45","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3390\/brainsci16020242","article-title":"Association of human gut microbiota with Alzheimer's disease pathogenesis: an exploratory clinical study","volume":"16","author":"Ohara","year":"2026","journal-title":"Brain Sci."},{"key":"2026100103065479100_RSTB20250265C46","doi-asserted-by":"crossref","first-page":"978","DOI":"10.3390\/cells11060978","article-title":"Hydrogen sulfide produced by gut bacteria may induce Parkinson's disease","volume":"11","author":"Murros","year":"2022","journal-title":"Cells"},{"key":"2026100103065479100_RSTB20250265C47","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.chom.2021.07.004","article-title":"Alterations in the gut microbiota contribute to cognitive impairment induced by the ketogenic diet and hypoxia","volume":"29","author":"Olson","year":"2021","journal-title":"Cell Host Microbe"},{"key":"2026100103065479100_RSTB20250265C48","doi-asserted-by":"crossref","first-page":"e00418","DOI":"10.1128\/mBio.00418-12","article-title":"Sensing of bacterial type IV secretion via the unfolded protein response","volume":"4","author":"de Jong","year":"2013","journal-title":"mBio"},{"key":"2026100103065479100_RSTB20250265C49","doi-asserted-by":"crossref","first-page":"e1003556","DOI":"10.1371\/journal.ppat.1003556","article-title":"Brucella modulates secretory trafficking via multiple type IV secretion effector proteins","volume":"9","author":"Myeni","year":"2013","journal-title":"PLoS Pathog."},{"key":"2026100103065479100_RSTB20250265C50","doi-asserted-by":"crossref","first-page":"1804126","DOI":"10.3389\/fnins.2026.1804126","article-title":"Unusual presentation of neurobrucellosis presenting with the features of parkinsonism: two case reports and a review of the literature","volume":"20","author":"Aldraihem","year":"2026","journal-title":"Front. Neurosci."},{"key":"2026100103065479100_RSTB20250265C51","doi-asserted-by":"crossref","first-page":"e02376","DOI":"10.1016\/j.idcr.2025.e02376","article-title":"Neurobrucellosis manifesting as secondary hemiparkinsonism in a veterinary technician: a case report and evidence-based review","volume":"42","author":"Sanchez","year":"2025","journal-title":"IDCases"},{"key":"2026100103065479100_RSTB20250265C52","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/s41467-026-68580-4","article-title":"Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina","volume":"17","author":"Gaire","year":"2026","journal-title":"Nat. Commun."},{"key":"2026100103065479100_RSTB20250265C53","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.bbrc.2018.11.034","article-title":"The molecular mechanism of induction of unfolded protein response by Chlamydia","volume":"508","author":"George","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2026100103065479100_RSTB20250265C54","doi-asserted-by":"crossref","first-page":"1181315","DOI":"10.3389\/fcimb.2023.1181315","article-title":"Desulfovibrio bacteria enhance alpha-synuclein aggregation in a Caenorhabditis elegans model of Parkinson's disease","volume":"13","author":"Huynh","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"2026100103065479100_RSTB20250265C55","doi-asserted-by":"crossref","first-page":"e2106504118","DOI":"10.1073\/pnas.2106504118","article-title":"Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration","volume":"118","author":"Wang","year":"2021","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2026100103065479100_RSTB20250265C56","doi-asserted-by":"crossref","first-page":"638867","DOI":"10.3389\/fimmu.2021.638867","article-title":"Microbiome or infections: amyloid-containing biofilms as a trigger for complex human diseases","volume":"12","author":"Miller","year":"2021","journal-title":"Front. Immunol."},{"key":"2026100103065479100_RSTB20250265C57","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.53111","article-title":"A gut bacterial amyloid promotes \u03b1-synuclein aggregation and motor impairment in mice","volume":"9","author":"Sampson","year":"2020","journal-title":"eLife"},{"key":"2026100103065479100_RSTB20250265C58","doi-asserted-by":"crossref","first-page":"34477","DOI":"10.1038\/srep34477","article-title":"Exposure to the functional bacterial amyloid protein curli enhances alpha-synuclein aggregation in aged Fischer 344 rats and Caenorhabditis elegans","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"2026100103065479100_RSTB20250265C59","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1038\/s41467-024-48309-x","article-title":"Gut microbiota produces biofilm-associated amyloids with potential for neurodegeneration","volume":"15","author":"Fern\u00e1ndez-Calvet","year":"2024","journal-title":"Nat. Comm."},{"key":"2026100103065479100_RSTB20250265C60","doi-asserted-by":"crossref","first-page":"1681308","DOI":"10.3389\/fmicb.2025.1681308","article-title":"The deubiquitinase ElaD is present in the majority of Escherichia coli strains","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Microbiol."},{"key":"2026100103065479100_RSTB20250265C61","doi-asserted-by":"crossref","first-page":"11638","DOI":"10.1038\/s41467-025-66499-w","article-title":"A noncanonical polyamine from bacteria antagonizes host mitochondrial function","volume":"16","author":"Nauta","year":"2025","journal-title":"Nat. Commun."},{"key":"2026100103065479100_RSTB20250265C62","doi-asserted-by":"crossref","first-page":"912709","DOI":"10.3389\/fnagi.2022.912709","article-title":"The periodontal pathogen Fusobacterium nucleatum exacerbates Alzheimer's pathogenesis via specific pathways","volume":"14","author":"Wu","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"2026100103065479100_RSTB20250265C63","doi-asserted-by":"crossref","first-page":"e02706","DOI":"10.1128\/mBio.02706-20","article-title":"Fusobacterium nucleatum secretes outer membrane vesicles and promotes intestinal inflammation","volume":"12","author":"Engevik","year":"2021","journal-title":"mBio"},{"key":"2026100103065479100_RSTB20250265C64","doi-asserted-by":"crossref","first-page":"1412157","DOI":"10.3389\/fimmu.2024.1412157","article-title":"Causal associations between Helicobacter pylori infection and the risk and symptoms of Parkinson's disease: a Mendelian randomization study","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Immunol."},{"key":"2026100103065479100_RSTB20250265C65","doi-asserted-by":"crossref","first-page":"e0251042","DOI":"10.1371\/journal.pone.0251042","article-title":"Helicobacter pylori eradication improves motor fluctuations in advanced Parkinson's disease patients: a prospective cohort study (HP-PD trial)","volume":"16","author":"Lolekha","year":"2021","journal-title":"PLoS ONE"},{"key":"2026100103065479100_RSTB20250265C66","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3233\/JAD-190496","article-title":"Alzheimer's disease and Helicobacter pylori infection: inflammation from stomach to brain?","volume":"73","author":"Albaret","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"2026100103065479100_RSTB20250265C67","doi-asserted-by":"crossref","first-page":"18346","DOI":"10.1038\/srep18346","article-title":"Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor","volume":"6","author":"Shimoda","year":"2016","journal-title":"Sci. Rep."},{"key":"2026100103065479100_RSTB20250265C68","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1093\/infdis\/jiae165","article-title":"An enteric bacterial infection triggers neuroinflammation and neurobehavioral impairment in 3xTg-AD transgenic mice","volume":"230","author":"Park","year":"2024","journal-title":"J. Infect. Dis."},{"key":"2026100103065479100_RSTB20250265C69","doi-asserted-by":"crossref","first-page":"7887","DOI":"10.1038\/ncomms8887","article-title":"Legionella suppresses the host unfolded protein response via multiple mechanisms","volume":"6","author":"Treacy-Abarca","year":"2015","journal-title":"Nat. Commun."},{"key":"2026100103065479100_RSTB20250265C70","doi-asserted-by":"crossref","first-page":"16953","DOI":"10.1073\/pnas.0601562103","article-title":"Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A","volume":"103","author":"Belyi","year":"2006","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2026100103065479100_RSTB20250265C71","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/j.1462-5822.2012.01769.x","article-title":"Activation of the unfolded protein response by Listeria monocytogenes","volume":"14","author":"Pillich","year":"2012","journal-title":"Cell. Microbiol."},{"key":"2026100103065479100_RSTB20250265C72","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1073\/pnas.1100126108","article-title":"Listeria monocytogenes transiently alters mitochondrial dynamics during infection","volume":"108","author":"Stavru","year":"2011","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2026100103065479100_RSTB20250265C73","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/j.febslet.2010.04.050","article-title":"Endoplasmic reticulum stress response is involved in Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis","volume":"584","author":"Choi","year":"2010","journal-title":"FEBS Lett."},{"key":"2026100103065479100_RSTB20250265C74","doi-asserted-by":"crossref","first-page":"e957","DOI":"10.1038\/cddis.2013.489","article-title":"Mycobacterial HBHA induces endoplasmic reticulum stress-mediated apoptosis through the generation of reactive oxygen species and cytosolic Ca2+ in murine macrophage RAW 264.7 cells","volume":"4","author":"Choi","year":"2013","journal-title":"Cell Death Dis."},{"key":"2026100103065479100_RSTB20250265C75","doi-asserted-by":"crossref","first-page":"eaau3333","DOI":"10.1126\/sciadv.aau3333","article-title":"Porphyromonas gingivalis in Alzheimer's disease brains: evidence for disease causation and treatment with small-molecule inhibitors","volume":"5","author":"Dominy","year":"2019","journal-title":"Sci. Adv."},{"key":"2026100103065479100_RSTB20250265C76","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1038\/s41598-020-59364-x","article-title":"Bacterial DNA promotes tau aggregation","volume":"10","author":"Tetz","year":"2020","journal-title":"Sci. Rep."},{"key":"2026100103065479100_RSTB20250265C77","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1002\/JPER.20-0104","article-title":"Porphyromonas gingivalis and Alzheimer disease: recent findings and potential therapies","volume":"91","author":"Ryder","year":"2020","journal-title":"J. Periodontol."},{"key":"2026100103065479100_RSTB20250265C78","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3233\/JAD-190298","article-title":"Porphyromonas gingivalis infection induces amyloid-\u03b2 accumulation in monocytes\/macrophages","volume":"72","author":"Nie","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"2026100103065479100_RSTB20250265C79","doi-asserted-by":"crossref","first-page":"1141339","DOI":"10.3389\/fncel.2023.1141339","article-title":"Porphyromonas gingivalis-induced periodontitis could contribute to cognitive impairment in Sprague-Dawley rats via the P38 MAPK signaling pathway","volume":"17","author":"Jin","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"2026100103065479100_RSTB20250265C80","doi-asserted-by":"crossref","first-page":"104887","DOI":"10.1016\/j.ebiom.2023.104887","article-title":"P. mirabilis-derived pore-forming haemolysin, HpmA drives intestinal alpha-synuclein aggregation in a mouse model of neurodegeneration","volume":"98","author":"Huh","year":"2023","journal-title":"EBioMedicine"},{"key":"2026100103065479100_RSTB20250265C81","doi-asserted-by":"crossref","first-page":"2070100","DOI":"10.1002\/advs.202070100","article-title":"Accelerated amyloid beta pathogenesis by bacterial amyloid FapC","volume":"7","author":"Javed","year":"2020","journal-title":"Adv. Sci. (Weinh)"},{"key":"2026100103065479100_RSTB20250265C82","doi-asserted-by":"crossref","first-page":"eadx7829","DOI":"10.1126\/sciadv.adx7829","article-title":"Structural basis of Pseudomonas biofilm-forming functional amyloid FapC formation","volume":"11","author":"Hansen","year":"2025","journal-title":"Sci. Adv."},{"key":"2026100103065479100_RSTB20250265C83","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.tibs.2005.12.007","article-title":"Stealth and mimicry by deadly bacterial toxins","volume":"31","author":"Yates","year":"2006","journal-title":"Trends Biochem. Sci."},{"key":"2026100103065479100_RSTB20250265C84","doi-asserted-by":"crossref","first-page":"1405376","DOI":"10.3389\/fimmu.2024.1405376","article-title":"Pseudomonas aeruginosa in chronic lung disease: untangling the dysregulated host immune response","volume":"15","author":"Nickerson","year":"2024","journal-title":"Front. Immunol."},{"key":"2026100103065479100_RSTB20250265C85","doi-asserted-by":"crossref","first-page":"16360","DOI":"10.1074\/jbc.M110.100669","article-title":"The Salmonella type III secretion effector, Salmonella leucine-rich repeat protein (SlrP), targets the human chaperone ERdj3","volume":"285","author":"Bernal-Bayard","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2026100103065479100_RSTB20250265C86","doi-asserted-by":"crossref","first-page":"e1005552","DOI":"10.1371\/journal.ppat.1005552","article-title":"The Salmonella effector protein SopA modulates innate immune responses by targeting TRIM E3 ligase family members","volume":"12","author":"Kamanova","year":"2016","journal-title":"PLoS Pathog."},{"key":"2026100103065479100_RSTB20250265C87","doi-asserted-by":"crossref","first-page":"e1002743","DOI":"10.1371\/journal.ppat.1002743","article-title":"The Salmonella deubiquitinase SseL inhibits selective autophagy of cytosolic aggregates","volume":"8","author":"Mesquita","year":"2012","journal-title":"PLoS Pathog."},{"key":"2026100103065479100_RSTB20250265C88","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.chom.2012.09.011","article-title":"The Salmonella kinase SteC targets the MAP kinase MEK to regulate the host actin cytoskeleton","volume":"12","author":"Odendall","year":"2012","journal-title":"Cell Host Microbe"},{"key":"2026100103065479100_RSTB20250265C89","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1042\/BC20050001","article-title":"Shiga toxin B-subunit binds to the chaperone BiP and the nucleolar protein B23","volume":"98","author":"Falgui\u00e8res","year":"2006","journal-title":"Biol. Cell"},{"key":"2026100103065479100_RSTB20250265C90","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1099\/mic.0.060855-0","article-title":"Functional amyloid formation by Streptococcus mutans","volume":"158","author":"Oli","year":"2012","journal-title":"Microbiology (Reading)"},{"key":"2026100103065479100_RSTB20250265C91","doi-asserted-by":"crossref","first-page":"e0114921","DOI":"10.1128\/AEM.01149-21","article-title":"Amyloid aggregation of Streptococcus mutans Cnm influences its collagen-binding activity","volume":"87","author":"di Cologna","year":"2021","journal-title":"Appl. Environ. Microbiol."},{"key":"2026100103065479100_RSTB20250265C92","doi-asserted-by":"crossref","first-page":"8216","DOI":"10.1038\/s41467-025-63473-4","article-title":"Gut microbial production of imidazole propionate drives Parkinson's pathologies","volume":"16","author":"Park","year":"2025","journal-title":"Nat. Commun."},{"key":"2026100103065479100_RSTB20250265C93","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.3390\/pathogens11101150","article-title":"Treponema denticola induces neuronal apoptosis by promoting amyloid-\u03b2 accumulation in mice","volume":"11","author":"Wu","year":"2022","journal-title":"Pathogens"},{"key":"2026100103065479100_RSTB20250265C94","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1046\/j.0902-0055.2001.00100.x","article-title":"Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer's disease","volume":"17","author":"Riviere","year":"2002","journal-title":"Oral Microbiol. Immunol."},{"key":"2026100103065479100_RSTB20250265C95","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1742-2094-8-90","article-title":"Alzheimer's disease \u2013 a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria","volume":"8","author":"Miklossy","year":"2011","journal-title":"J. Neuroinflamm."},{"key":"2026100103065479100_RSTB20250265C96","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.3390\/ijerph20116049","article-title":"Treponema denticola has the potential to cause neurodegeneration in the midbrain via the periodontal route of infection-narrative review","volume":"20","author":"Pisani","year":"2023","journal-title":"Int J. Environ. Res. Public Health"},{"key":"2026100103065479100_RSTB20250265C97","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.resmic.2003.08.001","article-title":"Role of dentilisin in Treponema denticola epithelial cell layer penetration","volume":"154","author":"Chi","year":"2003","journal-title":"Res. Microbiol."},{"key":"2026100103065479100_RSTB20250265C98","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1177\/00220345221076772","article-title":"Treponema denticola induces Alzheimer-like tau hyperphosphorylation by activating hippocampal neuroinflammation in mice","volume":"101","author":"Tang","year":"2022","journal-title":"J. Dent. Res."},{"key":"2026100103065479100_RSTB20250265C99","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0014-5793(03)01217-1","article-title":"BiP-dependent export of cholera toxin from endoplasmic reticulum-derived microsomes","volume":"554","author":"Winkeler","year":"2003","journal-title":"FEBS Lett."},{"key":"2026100103065479100_RSTB20250265C100","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3181\/0705-RM-132","article-title":"Cholera toxin up-regulates endoplasmic reticulum proteins that correlate with sensitivity to the toxin","volume":"233","author":"Dixit","year":"2008","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"2026100103065479100_RSTB20250265C101","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/0891988710383571","article-title":"Genetics of Alzheimer disease","volume":"23","author":"Bekris","year":"2010","journal-title":"J. Geriatr. Psychiatry. Neurol."},{"key":"2026100103065479100_RSTB20250265C102","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","article-title":"Epidemiology of Parkinson's disease","volume":"5","author":"de Lau","year":"2006","journal-title":"Lancet Neurol."},{"key":"2026100103065479100_RSTB20250265C103","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/s41591-025-03494-0","article-title":"Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia","volume":"31","author":"Llibre-Guerra","year":"2025","journal-title":"Nat. Med."},{"key":"2026100103065479100_RSTB20250265C104","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat. Genet."},{"key":"2026100103065479100_RSTB20250265C105","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev.med.47.1.387","article-title":"Apolipoprotein E alleles as risk factors in Alzheimer's disease","volume":"47","author":"Roses","year":"1996","journal-title":"Annu. Rev. Med."},{"key":"2026100103065479100_RSTB20250265C106","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1038\/s41591-025-03835-z","article-title":"APOE \u03b54 carriers share immune-related proteomic changes across neurodegenerative diseases","volume":"31","author":"Shvetcov","year":"2025","journal-title":"Nat. Med."},{"key":"2026100103065479100_RSTB20250265C107","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40035-024-00461-6","article-title":"Peripheral proteinopathy in neurodegenerative diseases","volume":"14","author":"Xu","year":"2025","journal-title":"Transl. Neurodegener."},{"key":"2026100103065479100_RSTB20250265C108","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrn3346","article-title":"Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour","volume":"13","author":"Cryan","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"2026100103065479100_RSTB20250265C109","doi-asserted-by":"crossref","first-page":"53829","DOI":"10.18632\/oncotarget.17754","article-title":"Microbiota-gut-brain axis and the central nervous system","volume":"8","author":"Zhu","year":"2017","journal-title":"Oncotarget"},{"key":"2026100103065479100_RSTB20250265C110","doi-asserted-by":"crossref","first-page":"101350","DOI":"10.1016\/j.molmet.2021.101350","article-title":"Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior","volume":"54","author":"Cook","year":"2021","journal-title":"Mol. Metab."},{"key":"2026100103065479100_RSTB20250265C111","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.chom.2020.11.011","article-title":"Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways","volume":"29","author":"Ye","year":"2021","journal-title":"Cell Host Microbe"},{"key":"2026100103065479100_RSTB20250265C112","doi-asserted-by":"crossref","first-page":"16050","DOI":"10.1073\/pnas.1102999108","article-title":"Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve","volume":"108","author":"Bravo","year":"2011","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2026100103065479100_RSTB20250265C113","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.3390\/ijms26031160","article-title":"Interaction of the vagus nerve and serotonin in the gut-brain axis","volume":"26","author":"Hwang","year":"2025","journal-title":"Int J. Mol. Sci."},{"key":"2026100103065479100_RSTB20250265C114","doi-asserted-by":"crossref","first-page":"eaat5236","DOI":"10.1126\/science.aat5236","article-title":"A gut-brain neural circuit for nutrient sensory transduction","volume":"361","author":"Kaelberer","year":"2018","journal-title":"Science"},{"key":"2026100103065479100_RSTB20250265C115","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/s41522-025-00810-x","article-title":"Enteroendocrine cells: the gatekeepers of microbiome-gut-brain communication","volume":"11","author":"Grundeken","year":"2025","journal-title":"NPJ Biofilms Microbiomes"},{"key":"2026100103065479100_RSTB20250265C116","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/nrgastro.2012.32","article-title":"The enteric nervous system and neurogastroenterology","volume":"9","author":"Furness","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"2026100103065479100_RSTB20250265C117","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota-gut-brain axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"2026100103065479100_RSTB20250265C118","doi-asserted-by":"crossref","first-page":"108721","DOI":"10.1016\/j.neuropharm.2021.108721","article-title":"Interactions between the microbiota and enteric nervous system during gut-brain disorders","volume":"197","author":"Fried","year":"2021","journal-title":"Neuropharmacology"},{"key":"2026100103065479100_RSTB20250265C119","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrgastro.2016.107","article-title":"The bowel and beyond: the enteric nervous system in neurological disorders","volume":"13","author":"Rao","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"2026100103065479100_RSTB20250265C120","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1152\/physrev.00018.2022","article-title":"The enteric nervous system","volume":"103","author":"Sharkey","year":"2023","journal-title":"Physiol. Rev."},{"key":"2026100103065479100_RSTB20250265C121","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fnins.2018.00049","article-title":"The vagus nerve at the interface of the microbiota-gut-brain axis","volume":"12","author":"Bonaz","year":"2018","journal-title":"Front. Neurosci."},{"key":"2026100103065479100_RSTB20250265C122","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1212\/WNL.0000000000003961","article-title":"Vagotomy and Parkinson disease: a Swedish register-based matched-cohort study","volume":"88","author":"Liu","year":"2017","journal-title":"Neurology"},{"key":"2026100103065479100_RSTB20250265C123","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/ana.24448","article-title":"Vagotomy and subsequent risk of Parkinson's disease","volume":"78","author":"Svensson","year":"2015","journal-title":"Ann. Neurol."},{"key":"2026100103065479100_RSTB20250265C124","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2014.03.011","article-title":"Role of the microbiota in immunity and inflammation","volume":"157","author":"Belkaid","year":"2014","journal-title":"Cell"},{"key":"2026100103065479100_RSTB20250265C125","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1053\/j.gastro.2020.09.060","article-title":"Aging, frailty, and the microbiome-how dysbiosis influences human aging and disease","volume":"160","author":"Haran","year":"2021","journal-title":"Gastroenterology"},{"key":"2026100103065479100_RSTB20250265C126","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nri.2016.42","article-title":"Gut microbiota, metabolites and host immunity","volume":"16","author":"Rooks","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"2026100103065479100_RSTB20250265C127","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nn.4030","article-title":"Host microbiota constantly control maturation and function of microglia in the CNS","volume":"18","author":"Erny","year":"2015","journal-title":"Nat. Neurosci."},{"key":"2026100103065479100_RSTB20250265C128","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41577-022-00684-6","article-title":"Inflammation and immune dysfunction in Parkinson disease","volume":"22","author":"Tansey","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"2026100103065479100_RSTB20250265C129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2014.08.007","article-title":"The blood-brain barrier in neuroimmunology: tales of separation and assimilation","volume":"44","author":"Banks","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"2026100103065479100_RSTB20250265C130","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","article-title":"The role of short-chain fatty acids in microbiota\u2013gut\u2013brain communication","volume":"16","author":"Dalile","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"2026100103065479100_RSTB20250265C131","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s40168-024-01750-y","article-title":"Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding","volume":"12","author":"Wang","year":"2024","journal-title":"Microbiome"},{"key":"2026100103065479100_RSTB20250265C132","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.bbi.2024.08.051","article-title":"Microbiome-derived indole-3-lactic acid reduces amyloidopathy through aryl-hydrocarbon receptor activation","volume":"122","author":"Kim","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"2026100103065479100_RSTB20250265C133","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuroscience.2025.04.050","article-title":"Association between the relative abundance of butyrate-producing and mucin-degrading taxa and Parkinson's disease","volume":"576","author":"Rust","year":"2025","journal-title":"Neuroscience"},{"key":"2026100103065479100_RSTB20250265C134","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41586-025-09984-y","article-title":"Intestinal macrophages modulate synucleinopathy along the gut\u2013brain axis","volume":"651","author":"De Schepper","year":"2026","journal-title":"Nature"},{"key":"2026100103065479100_RSTB20250265C135","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cell.2015.02.047","article-title":"Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis","volume":"161","author":"Yano","year":"2015","journal-title":"Cell"},{"key":"2026100103065479100_RSTB20250265C136","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.2004.063388","article-title":"Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice","volume":"558","author":"Sudo","year":"2004","journal-title":"J. Physiol."},{"key":"2026100103065479100_RSTB20250265C137","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nrgastro.2015.121","article-title":"Towards a systems view of IBS","volume":"12","author":"Mayer","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"2026100103065479100_RSTB20250265C138","doi-asserted-by":"crossref","first-page":"po0041","DOI":"10.1099\/acmi.ac2019.po0041","article-title":"Redefining a new genomic blueprint of the human gut microbiota","volume":"1","author":"Almeida","year":"2019","journal-title":"Access Microbiol."},{"key":"2026100103065479100_RSTB20250265C139","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s44324-025-00066-1","article-title":"Mechanisms and implications of the gut microbial modulation of intestinal metabolic processes","volume":"3","author":"Jyoti","year":"2025","journal-title":"npj Metabolic Health Dis."},{"key":"2026100103065479100_RSTB20250265C140","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.14336\/AD.2022.0104","article-title":"Functions of gut microbiota metabolites, current status and future perspectives","volume":"13","author":"Liu","year":"2022","journal-title":"Aging Dis."},{"key":"2026100103065479100_RSTB20250265C141","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1136\/gutjnl-2024-334571","article-title":"Pathological tau propagation from the brain to the colon via the vagal efferent pathway in Alzheimer's disease","volume":"75","author":"Choi","year":"2026","journal-title":"Gut"},{"key":"2026100103065479100_RSTB20250265C142","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41419-022-05531-z","article-title":"Intrastriatal injection of Parkinson's disease intestine and vagus lysates initiates \u03b1-synucleinopathy in rat brain","volume":"14","author":"Yang","year":"2023","journal-title":"Cell Death. Dis."},{"key":"2026100103065479100_RSTB20250265C143","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41593-020-0589-7","article-title":"Gut-seeded \u03b1-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice","volume":"23","author":"Challis","year":"2020","journal-title":"Nat. Neurosci."},{"key":"2026100103065479100_RSTB20250265C144","doi-asserted-by":"crossref","first-page":"7205","DOI":"10.3390\/ijms24087205","article-title":"Gut-to-brain \u03b1-synuclein transmission in Parkinson's disease: evidence for prion-like mechanisms","volume":"24","author":"Chen","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"2026100103065479100_RSTB20250265C145","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13024-018-0257-5","article-title":"Inoculation of \u03b1-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve","volume":"13","author":"Uemura","year":"2018","journal-title":"Mol. Neurodegenerat."},{"key":"2026100103065479100_RSTB20250265C146","doi-asserted-by":"crossref","first-page":"e106320","DOI":"10.15252\/embj.2020106320","article-title":"Gut inflammation triggers C\/EBP\u03b2\/\u03b4-secretase-dependent gut-to-brain propagation of a\u03b2 and tau fibrils in Alzheimer's disease","volume":"40","author":"Chen","year":"2021","journal-title":"EMBO J."},{"key":"2026100103065479100_RSTB20250265C147","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"key":"2026100103065479100_RSTB20250265C148","doi-asserted-by":"crossref","first-page":"13537","DOI":"10.1038\/s41598-017-13601-y","article-title":"Gut microbiome alterations in Alzheimer's disease","volume":"7","author":"Vogt","year":"2017","journal-title":"Sci. Rep."},{"key":"2026100103065479100_RSTB20250265C149","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41586-019-1443-5","article-title":"Potential roles of gut microbiome and metabolites in modulating ALS in mice","volume":"572","author":"Blacher","year":"2019","journal-title":"Nature"},{"key":"2026100103065479100_RSTB20250265C150","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13073-017-0428-y","article-title":"Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-na\u00efve Parkinson's disease patients","volume":"9","author":"Bedarf","year":"2017","journal-title":"Genome Med."},{"key":"2026100103065479100_RSTB20250265C151","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/mds.27105","article-title":"The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder","volume":"33","author":"Heintz-Buschart","year":"2018","journal-title":"Mov. Disord."},{"key":"2026100103065479100_RSTB20250265C152","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/s41398-021-01689-w","article-title":"Proteomics analysis of the gut-brain axis in a gut microbiota-dysbiosis model of depression","volume":"11","author":"Liu","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"2026100103065479100_RSTB20250265C153","doi-asserted-by":"crossref","first-page":"e0312122","DOI":"10.1128\/mbio.03121-22","article-title":"Modelling the gastrointestinal carriage of Klebsiella pneumoniae infections","volume":"14","author":"Calderon-Gonzalez","year":"2023","journal-title":"mBio"},{"key":"2026100103065479100_RSTB20250265C154","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.4269\/ajtmh.17-0282","article-title":"A high burden of asymptomatic gastrointestinal infections in traditional communities in Papua New Guinea","volume":"97","author":"Horwood","year":"2017","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"2026100103065479100_RSTB20250265C155","doi-asserted-by":"crossref","first-page":"595","DOI":"10.4269\/ajtmh.17-0339","article-title":"High prevalence of Shigella or enteroinvasive Escherichia coli carriage among residents of an internally displaced persons camp in South Sudan","volume":"98","author":"Bliss","year":"2018","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"2026100103065479100_RSTB20250265C156","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/1574-6941.12301","article-title":"Faecal carriage of Pseudomonas aeruginosa in healthy humans: antimicrobial susceptibility and global genetic lineages","volume":"89","author":"Estepa","year":"2014","journal-title":"FEMS Microbiol. Ecol."},{"key":"2026100103065479100_RSTB20250265C157","doi-asserted-by":"crossref","first-page":"e0011716","DOI":"10.1371\/journal.pntd.0011716","article-title":"The epidemiology of fecal carriage of nontyphoidal Salmonella among healthy children and adults in three sites in Kenya","volume":"17","author":"Muthumbi","year":"2023","journal-title":"PLoS Negl. Trop. Dis."},{"key":"2026100103065479100_RSTB20250265C158","doi-asserted-by":"crossref","first-page":"e10109","DOI":"10.1002\/advs.202510109","article-title":"The evolution of functional amyloids and their impact on host-microbe interactions","volume":"12","author":"Kolli","year":"2025","journal-title":"Adv. Sci."},{"key":"2026100103065479100_RSTB20250265C159","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1099\/0022-1317-49-9-817","article-title":"Profiling of bacterial flora in gastric biopsies from patients with Helicobacter pylori-associated gastritis and histologically normal control individuals by temperature gradient gel electrophoresis and 16S rDNA sequence analysis","volume":"49","author":"Monstein","year":"2000","journal-title":"J. Med. Microbiol."},{"key":"2026100103065479100_RSTB20250265C160","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.3390\/ijms26062695","article-title":"Biofilm-associated amyloid proteins linked with the progression of neurodegenerative diseases","volume":"26","author":"Singh","year":"2025","journal-title":"Int J. Mol. Sci"},{"key":"2026100103065479100_RSTB20250265C161","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1111\/febs.13722","article-title":"Sequestration of cellular interacting partners by protein aggregates: implication in a loss-of-function pathology","volume":"283","author":"Yang","year":"2016","journal-title":"FEBS J."},{"key":"2026100103065479100_RSTB20250265C162","doi-asserted-by":"crossref","first-page":"100567","DOI":"10.1016\/j.jbc.2021.100567","article-title":"Suppression of aggregate and amyloid formation by a novel intrinsically disordered region in metazoan Hsp110 chaperones","volume":"296","author":"Yakubu","year":"2021","journal-title":"J. Biol. Chem."},{"key":"2026100103065479100_RSTB20250265C163","doi-asserted-by":"crossref","first-page":"7206","DOI":"10.1073\/pnas.0802593105","article-title":"Chaperone-dependent amyloid assembly protects cells from prion toxicity","volume":"105","author":"Douglas","year":"2008","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2026100103065479100_RSTB20250265C164","doi-asserted-by":"crossref","first-page":"a033969","DOI":"10.1101\/cshperspect.a033969","article-title":"Modulation of amyloid states by molecular chaperones","volume":"11","author":"Wentink","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2026100103065479100_RSTB20250265C165","doi-asserted-by":"crossref","first-page":"e13384","DOI":"10.1111\/cmi.13384","article-title":"Host manipulation by bacterial type III and type IV secretion system effector proteases","volume":"23","author":"Viana","year":"2021","journal-title":"Cell Microbiol."},{"key":"2026100103065479100_RSTB20250265C166","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","article-title":"Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities","volume":"21","author":"Hajishengallis","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"2026100103065479100_RSTB20250265C167","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1021\/acs.jproteome.8b00860","article-title":"Localization of outer membrane proteins in Treponema denticola by quantitative proteome analyses of outer membrane vesicles and cellular fractions","volume":"18","author":"Veith","year":"2019","journal-title":"J. Proteome Res."},{"key":"2026100103065479100_RSTB20250265C168","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1093\/infdis\/jiae228","article-title":"Bacterial membrane vesicles: the missing link between bacterial infection and Alzheimer disease","volume":"230","author":"Butler","year":"2024","journal-title":"J. Infect. Dis."},{"key":"2026100103065479100_RSTB20250265C169","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1084\/jem.20090782","article-title":"Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes","volume":"206","author":"Hu","year":"2009","journal-title":"J. Exp. Med."},{"key":"2026100103065479100_RSTB20250265C170","doi-asserted-by":"crossref","DOI":"10.1186\/s12979-023-00404-1","article-title":"Helicobacter pylori infection and Parkinson's disease: etiology, pathogenesis and levodopa bioavailability","volume":"21","author":"Wei","year":"2024","journal-title":"Immun. Ageing"},{"key":"2026100103065479100_RSTB20250265C171","doi-asserted-by":"crossref","first-page":"eads7525","DOI":"10.1126\/sciadv.ads7525","article-title":"Helicobacter pylori CagA protein is a potent and broad-spectrum amyloid inhibitor","volume":"11","author":"Jin","year":"2025","journal-title":"Sci. Adv."},{"key":"2026100103065479100_RSTB20250265C172","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/s41418-020-0495-2","article-title":"TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses","volume":"27","author":"Di Rienzo","year":"2020","journal-title":"Cell Death Differ."},{"key":"2026100103065479100_RSTB20250265C173","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s42003-026-09703-x","article-title":"Tau is necessary for Pseudomonas aeruginosa-induced blood-brain barrier dysfunction","volume":"9","author":"Chaney","year":"2026","journal-title":"Commun. Biol."},{"key":"2026100103065479100_RSTB20250265C174","doi-asserted-by":"crossref","DOI":"10.1093\/femsml\/uqaf046","article-title":"A subset of type 4 secretion system effectors of Brucella spp. associates to outer membrane vesicles","volume":"7","author":"Ketterer","year":"2026","journal-title":"Microlife"},{"key":"2026100103065479100_RSTB20250265C175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.30699\/ijp.2024.2031417.3312","article-title":"Vacuolating cytotoxin A (VacA) and extracellular vesicles in Helicobacter pylori: two key arms in disease development","volume":"20","author":"Alavi Rostami","year":"2025","journal-title":"Iran J. Pathol."},{"key":"2026100103065479100_RSTB20250265C176","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3390\/toxins12070449","article-title":"Shiga toxin uptake and sequestration in extracellular vesicles is mediated by its B-subunit","volume":"12","author":"Willysson","year":"2020","journal-title":"Toxins (Basel)"},{"key":"2026100103065479100_RSTB20250265C177","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1074\/jbc.RA118.006472","article-title":"Listeria monocytogenes virulence factors, including listeriolysin O, are secreted in biologically active extracellular vesicles","volume":"294","author":"Coelho","year":"2019","journal-title":"J. Biol. Chem."},{"key":"2026100103065479100_RSTB20250265C178","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.febslet.2011.04.017","article-title":"Association of cholera toxin with Vibrio cholerae outer membrane vesicles which are internalized by human intestinal epithelial cells","volume":"585","author":"Chatterjee","year":"2011","journal-title":"FEBS Lett."},{"key":"2026100103065479100_RSTB20250265C179","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s00018-023-04819-3","article-title":"Intestinal infection triggers mitochondria-mediated \u03b1-synuclein pathology: relevance to Parkinson's disease","volume":"80","author":"Magalh\u00e3es","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"2026100103065479100_RSTB20250265C180","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neulet.2016.02.009","article-title":"Butyrate, neuroepigenetics and the gut microbiome: can a high fiber diet improve brain health?","volume":"625","author":"Bourassa","year":"2016","journal-title":"Neurosci. Lett."},{"key":"2026100103065479100_RSTB20250265C181","doi-asserted-by":"crossref","first-page":"111772","DOI":"10.1016\/j.yexcr.2019.111772","article-title":"Sodium butyrate causes \u03b1-synuclein degradation by an Atg5-dependent and PI3K\/Akt\/mTOR-related autophagy pathway","volume":"387","author":"Qiao","year":"2020","journal-title":"Exp. Cell Res."},{"key":"2026100103065479100_RSTB20250265C182","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/mds.29300","article-title":"Integrated multi-cohort analysis of the Parkinson's disease gut metagenome","volume":"38","author":"Boktor","year":"2023","journal-title":"Mov. Disord."},{"key":"2026100103065479100_RSTB20250265C183","doi-asserted-by":"crossref","first-page":"6958","DOI":"10.1038\/s41467-022-34667-x","article-title":"Metagenomics of Parkinson's disease implicates the gut microbiome in multiple disease mechanisms","volume":"13","author":"Wallen","year":"2022","journal-title":"Nat. Commun."},{"key":"2026100103065479100_RSTB20250265C184","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3233\/JAD-2011-110080","article-title":"Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression","volume":"26","author":"Govindarajan","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"2026100103065479100_RSTB20250265C185","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.clinthera.2016.12.014","article-title":"Target intestinal microbiota to alleviate disease progression in amyotrophic lateral sclerosis","volume":"39","author":"Zhang","year":"2017","journal-title":"Clin. Ther."},{"key":"2026100103065479100_RSTB20250265C186","doi-asserted-by":"crossref","first-page":"708","DOI":"10.3390\/nu10060708","article-title":"Changes of colonic bacterial composition in Parkinson's disease and other neurodegenerative diseases","volume":"10","author":"Gerhardt","year":"2018","journal-title":"Nutrients"},{"key":"2026100103065479100_RSTB20250265C187","doi-asserted-by":"crossref","first-page":"104268","DOI":"10.1016\/j.nbd.2018.09.001","article-title":"Microbiome profiling reveals gut dysbiosis in a transgenic mouse model of Huntington's disease","volume":"135","author":"Kong","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"2026100103065479100_RSTB20250265C188","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s00415-025-13545-8","article-title":"The role of the gut microbiome in the progression of Parkinson's disease: a systematic review of patient cohorts","volume":"273","author":"Peters","year":"2026","journal-title":"J. Neurol."},{"key":"2026100103065479100_RSTB20250265C189","doi-asserted-by":"crossref","first-page":"109525","DOI":"10.1016\/j.abb.2023.109525","article-title":"N-butyrate increases heat shock protein 70 through heat shock factor 1 and AMP-activated protein kinase pathways in human intestinal Caco-2 cells","volume":"736","author":"Adesina","year":"2023","journal-title":"Arch. Biochem. Biophys."},{"key":"2026100103065479100_RSTB20250265C190","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/ijc.10236","article-title":"Proteome analysis of butyrate-treated human colon cancer cells (HT-29)","volume":"98","author":"Tan","year":"2002","journal-title":"Int. J. Cancer"},{"key":"2026100103065479100_RSTB20250265C191","doi-asserted-by":"crossref","first-page":"e23429","DOI":"10.1096\/fj.202300963RR","article-title":"Treatment with sodium butyrate induces autophagy resulting in therapeutic benefits for spinocerebellar ataxia type 3","volume":"38","author":"Watchon","year":"2024","journal-title":"FASEB J."},{"key":"2026100103065479100_RSTB20250265C192","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/sj.cr.7310074","article-title":"Effects of histone deacetylase inhibitors on transcriptional regulation of the hsp70 gene in Drosophila","volume":"16","author":"Zhao","year":"2006","journal-title":"Cell Res."},{"key":"2026100103065479100_RSTB20250265C193","doi-asserted-by":"crossref","first-page":"e00252","DOI":"10.1128\/iai.00252-22","article-title":"Butyrate ameliorates intraocular bacterial infection by promoting autophagy and attenuating the inflammatory response","volume":"91","author":"Singh","year":"2023","journal-title":"Infect. Immun."},{"key":"2026100103065479100_RSTB20250265C194","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41598-025-29618-7","article-title":"Sodium butyrate-induced autophagy in colorectal cancer unveils the Ca\u00b2\u207a\/CaMKK\u03b2 signaling pathway as a potential therapeutic target","volume":"16","author":"Luo","year":"2025","journal-title":"Sci. Rep."},{"key":"2026100103065479100_RSTB20250265C195","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1038\/s41467-026-70547-4","article-title":"Butyrate extends health and lifespan in mice with mitochondrial deficiency","volume":"17","author":"Gaband\u00e9-Rodr\u00edguez","year":"2026","journal-title":"Nat. Commun."},{"key":"2026100103065479100_RSTB20250265C196","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1111\/jcmm.17342","article-title":"Sodium butyrate reverses lipopolysaccharide-induced mitochondrial dysfunction in lymphoblasts","volume":"26","author":"Weiss","year":"2022","journal-title":"J. Cell Mol. Med."},{"key":"2026100103065479100_RSTB20250265C197","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1038\/s41598-022-27086-x","article-title":"Inhibition of inflammatory microglia by dietary fiber and short-chain fatty acids","volume":"13","author":"Caetano-Silva","year":"2023","journal-title":"Sci. Rep"},{"key":"2026100103065479100_RSTB20250265C198","doi-asserted-by":"crossref","first-page":"2389319","DOI":"10.1080\/19490976.2024.2389319","article-title":"Age-associated temporal decline in butyrate-producing bacteria plays a key pathogenic role in the onset and progression of neuropathology and memory deficits in 3\u00d7Tg-AD mice","volume":"16","author":"Chilton","year":"2024","journal-title":"Gut Microbes"},{"key":"2026100103065479100_RSTB20250265C199","doi-asserted-by":"crossref","first-page":"111661","DOI":"10.1016\/j.biopha.2021.111661","article-title":"Role of microbiota-derived short-chain fatty acids in nervous system disorders","volume":"139","author":"Mirzaei","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"2026100103065479100_RSTB20250265C200","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.clnu.2022.10.024","article-title":"Butyrate's role in human health and the current progress towards its clinical application to treat gastrointestinal disease","volume":"42","author":"Hodgkinson","year":"2023","journal-title":"Clin. Nutr."},{"key":"2026100103065479100_RSTB20250265C201","doi-asserted-by":"crossref","first-page":"dmm049969","DOI":"10.1242\/dmm.049969","article-title":"Intestinal barrier dysfunction: an evolutionarily conserved hallmark of aging","volume":"16","author":"Salazar","year":"2023","journal-title":"Dis. Model Mech."},{"key":"2026100103065479100_RSTB20250265C202","doi-asserted-by":"crossref","first-page":"2172671","DOI":"10.1080\/19490976.2023.2172671","article-title":"Bile acids as modulators of gut microbiota composition and function","volume":"15","author":"Larabi","year":"2023","journal-title":"Gut Microbes"},{"key":"2026100103065479100_RSTB20250265C203","doi-asserted-by":"crossref","first-page":"5982","DOI":"10.3390\/ijms21175982","article-title":"Bile acid signaling in neurodegenerative and neurological disorders","volume":"21","author":"Grant","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"2026100103065479100_RSTB20250265C204","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3233\/ADR-220071","article-title":"The pathological effects of circulating hydrophobic bile acids in Alzheimer's disease","volume":"7","author":"Ehtezazi","year":"2023","journal-title":"J. Alzheimers Dis. Rep."},{"key":"2026100103065479100_RSTB20250265C205","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.3390\/antiox11091706","article-title":"Bile acids induce alterations in mitochondrial function in skeletal muscle fibers","volume":"11","author":"Abrigo","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"2026100103065479100_RSTB20250265C206","doi-asserted-by":"crossref","first-page":"1769792","DOI":"10.3389\/fimmu.2026.1769792","article-title":"Microbial transformation of secondary bile acids: roles in gut ecology and autoimmune diseases","volume":"17","author":"Ren","year":"2026","journal-title":"Front. Immunol."},{"key":"2026100103065479100_RSTB20250265C207","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.tcb.2023.08.002","article-title":"Spermidine \u2013 an old molecule with a new age-defying immune function","volume":"34","author":"Chamoto","year":"2024","journal-title":"Trends Cell Biol."},{"key":"2026100103065479100_RSTB20250265C208","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/s41467-025-56105-4","article-title":"Lactobacillus reuteri ZJ617 attenuates metabolic syndrome via microbiota-derived spermidine","volume":"16","author":"Ma","year":"2025","journal-title":"Nat. Commun."},{"key":"2026100103065479100_RSTB20250265C209","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00726-026-03505-5","article-title":"Probiotic and microbial modulation of polyamine production: an emerging avenue for neuroprotection in neurodegenerative disorders","volume":"58","author":"Adhikari","year":"2026","journal-title":"Amino Acids"},{"key":"2026100103065479100_RSTB20250265C210","doi-asserted-by":"crossref","first-page":"10239","DOI":"10.1038\/s41467-025-65426-3","article-title":"Spermine modulation of Alzheimer's Tau and Parkinson's \u03b1-synuclein: implications for biomolecular condensation and neurodegeneration","volume":"16","author":"Sun","year":"2025","journal-title":"Nat. Commun."},{"key":"2026100103065479100_RSTB20250265C211","doi-asserted-by":"crossref","first-page":"115123","DOI":"10.1016\/j.celrep.2024.115123","article-title":"Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS","volume":"44","author":"Ruggieri","year":"2025","journal-title":"Cell Rep."},{"key":"2026100103065479100_RSTB20250265C212","doi-asserted-by":"crossref","first-page":"G181","DOI":"10.1152\/ajpgi.00054.2011","article-title":"Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response","volume":"301","author":"Iwashita","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2026100103065479100_RSTB20250265C213","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/s41531-025-01087-9","article-title":"Regulation of polyamine interconversion enzymes affects \u03b1-synuclein levels and toxicity in a Drosophila model of Parkinson's disease","volume":"11","author":"Ranxhi","year":"2025","journal-title":"NPJ Parkinsons Dis."},{"key":"2026100103065479100_RSTB20250265C214","doi-asserted-by":"crossref","first-page":"866","DOI":"10.3390\/microorganisms3040866","article-title":"Hydrogen sulfide in physiology and diseases of the digestive tract","volume":"3","author":"Singh","year":"2015","journal-title":"Microorganisms"},{"key":"2026100103065479100_RSTB20250265C215","doi-asserted-by":"crossref","first-page":"e2017225118","DOI":"10.1073\/pnas.2017225118","article-title":"Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3\u03b2 and inhibiting tau hyperphosphorylation","volume":"118","author":"Giovinazzo","year":"2021","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2026100103065479100_RSTB20250265C216","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1021\/jp508471v","article-title":"Hydrogen sulfide inhibits amyloid formation","volume":"119","author":"Rosario-Alomar","year":"2015","journal-title":"J. Phys. Chem. B"},{"key":"2026100103065479100_RSTB20250265C217","doi-asserted-by":"crossref","first-page":"108433","DOI":"10.1016\/j.jbc.2025.108433","article-title":"H(2)S remodels mitochondrial ultrastructure and destabilizes respiratory supercomplexes","volume":"301","author":"Hanna","year":"2025","journal-title":"J. Biol. Chem."},{"key":"2026100103065479100_RSTB20250265C218","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1038\/s41467-018-05249-7","article-title":"Bilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice","volume":"9","author":"Natividad","year":"2018","journal-title":"Nat. Commun."},{"key":"2026100103065479100_RSTB20250265C219","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1128\/IAI.70.3.1113-1120.2002","article-title":"Role of glutathione metabolism of Treponema denticola in bacterial growth and virulence expression","volume":"70","author":"Chu","year":"2002","journal-title":"Infect. Immun."},{"key":"2026100103065479100_RSTB20250265C220","doi-asserted-by":"crossref","first-page":"100549","DOI":"10.1016\/j.jfp.2025.100549","article-title":"Hydrogen sulfide negative Salmonella and their implication for standard culture-based identification","volume":"88","author":"Bentum","year":"2025","journal-title":"J. Food Prot."},{"key":"2026100103065479100_RSTB20250265C221","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/alz.12305","article-title":"Plasma hydrogen sulfide: a biomarker of Alzheimer's disease and related dementias","volume":"17","author":"Disbrow","year":"2021","journal-title":"Alzheimers Dement."},{"key":"2026100103065479100_RSTB20250265C222","first-page":"301","article-title":"Trimethylamine N-oxide (TMAO) in human health","volume":"20","author":"Gatarek","year":"2021","journal-title":"EXCLI J."},{"key":"2026100103065479100_RSTB20250265C223","first-page":"1275","article-title":"Assessment of trimethylamine-N-oxide at the blood-cerebrospinal fluid barrier: results from 290 lumbar punctures","volume":"19","author":"Enko","year":"2020","journal-title":"EXCLI J."},{"key":"2026100103065479100_RSTB20250265C224","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s11357-020-00257-2","article-title":"The gut microbiome-derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging","volume":"43","author":"Brunt","year":"2021","journal-title":"Geroscience"},{"key":"2026100103065479100_RSTB20250265C225","doi-asserted-by":"crossref","first-page":"e20000","DOI":"10.7717\/peerj.20000","article-title":"Association between levels of trimethylamine N-oxide and cognitive dysfunction: a systematic review and meta-analysis","volume":"13","author":"Ren","year":"2025","journal-title":"PeerJ"},{"key":"2026100103065479100_RSTB20250265C226","doi-asserted-by":"crossref","first-page":"102034","DOI":"10.1016\/j.tice.2023.102034","article-title":"TMAO promotes dementia progression by mediating the PI3K\/Akt\/mTOR pathway","volume":"81","author":"Hu","year":"2023","journal-title":"Tissue Cell"},{"key":"2026100103065479100_RSTB20250265C227","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ibneur.2026.02.006","article-title":"Elevated serum trimethylamine N-oxide (TMAO) and trimethyllysine in patients with amyotrophic lateral sclerosis (ALS): an exploratory case-control study","volume":"20","author":"Sotgia","year":"2026","journal-title":"IBRO Neurosci. Rep."},{"key":"2026100103065479100_RSTB20250265C228","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13195-018-0451-2","article-title":"The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease","volume":"10","author":"Vogt","year":"2018","journal-title":"Alzheimers Res. Ther."},{"key":"2026100103065479100_RSTB20250265C229","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00018-024-05546-z","article-title":"TMAO accelerates cellular aging by disrupting endoplasmic reticulum integrity and mitochondrial unfolded protein response","volume":"82","author":"Varzideh","year":"2025","journal-title":"Cell. Mol. Life Sci."},{"key":"2026100103065479100_RSTB20250265C230","doi-asserted-by":"crossref","first-page":"118592","DOI":"10.1016\/j.biopha.2025.118592","article-title":"Trimethylamine N-oxide (TMAO) and cancer risk: insights into a possible link","volume":"192","author":"Saha","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"2026100103065479100_RSTB20250265C231","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1007\/s11357-024-01488-3","article-title":"The role of the Mediterranean diet in reducing the risk of cognitive impairment, dementia, and Alzheimer's disease: a meta-analysis","volume":"47","author":"Fekete","year":"2025","journal-title":"Geroscience"},{"key":"2026100103065479100_RSTB20250265C232","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.nutres.2026.04.009","article-title":"Habitual natto consumption is inversely associated with mild cognitive impairment and depressive symptoms in older Japanese adults: a cross-sectional study","volume":"150","author":"Araki","year":"2026","journal-title":"Nutr. Res."},{"key":"2026100103065479100_RSTB20250265C233","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.3390\/microorganisms13081956","article-title":"Fecal microbiota transplantation in Alzheimer's disease: mechanistic insights through the microbiota-gut-brain axis and therapeutic prospects","volume":"13","author":"Ren","year":"2025","journal-title":"Microorganisms"},{"key":"2026100103065479100_RSTB20250265C234","doi-asserted-by":"crossref","first-page":"1598011","DOI":"10.3389\/fnins.2025.1598011","article-title":"The role of probiotics, prebiotics, and postbiotics: cellular and molecular pathways activated on glial cells in Alzheimer's disease","volume":"19","author":"Patricio-Mart\u00ednez","year":"2025","journal-title":"Front. Neurosci."},{"key":"2026100103065479100_RSTB20250265C235","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/nu14010020","article-title":"Probiotics for Alzheimer's disease: a systematic review","volume":"14","author":"Naomi","year":"2021","journal-title":"Nutrients"},{"key":"2026100103065479100_RSTB20250265C236","doi-asserted-by":"crossref","first-page":"2623359","DOI":"10.1080\/19490976.2026.2623359","article-title":"Precise probiotic therapy: advances, bottlenecks, and the road to microbiome-informed nutrition","volume":"18","author":"Jiang","year":"2026","journal-title":"Gut Microbes"},{"key":"2026100103065479100_RSTB20250265C237","doi-asserted-by":"crossref","first-page":"e70037","DOI":"10.1111\/1750-3841.70037","article-title":"Efficacy of probiotic supplementation in influencing cognitive function in Alzheimer's disease: a systematic review and meta-analysis","volume":"90","author":"Liu","year":"2025","journal-title":"J. Food Sci."}],"container-title":["Philosophical Transactions of the Royal Society B: Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article-pdf\/doi\/10.1098\/rstb.2025.0265\/6168580\/rstb.2025.0265.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article-pdf\/doi\/10.1098\/rstb.2025.0265\/6168580\/rstb.2025.0265.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:07:33Z","timestamp":1790838453000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/rstb\/article\/381\/1960\/20250265\/483483\/The-microbiota-proteostasis-axis-implications-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":237,"journal-issue":{"issue":"1960","published-online":{"date-parts":[[2026,10,1]]},"published-print":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.1098\/rstb.2025.0265","relation":{},"ISSN":["0962-8436","1471-2970"],"issn-type":[{"value":"0962-8436","type":"print"},{"value":"1471-2970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"article-number":"20250265"}}