{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:56:33Z","timestamp":1790841393510,"version":"4.1.0"},"reference-count":108,"publisher":"The Royal Society","issue":"1960","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KI1988\/15-1"],"award-info":[{"award-number":["KI1988\/15-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Allen Frontiers Group","id":[{"id":"https:\/\/ror.org\/01degd278","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Huntington's disease is caused by the trinucleotide repeat CAG expansion in the huntingtin gene, resulting in an N-terminal polyglutamine (polyQ) tract that renders the huntingtin protein (HTT) prone to misfolding and aggregation. Although polyQ expansion is an intrinsic driver of aggregation, the folding trajectory of HTT is strongly shaped by molecular chaperones that detect all conformational entities of HTT and as such bind to soluble HTT and suppress \u03b2-sheet formation, target HTT for proteasomal degradation and resolubilize HTT fibrils by disaggregation. This review summarizes recent in vitro and in vivo data on the role of molecular chaperones in the HTTExon1 folding landscape and its cooperation with the proteolytic pathways.<\/jats:p>\n                  <jats:p>This article is part of the Theo Murphy meeting issue \u2018ProteostaSys: a systems view of proteostasis'.<\/jats:p>","DOI":"10.1098\/rstb.2025.0269","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:07:52Z","timestamp":1790838472000},"source":"Crossref","is-referenced-by-count":0,"title":["Chaperone-mediated remodelling of mutant huntingtin"],"prefix":"10.1098","volume":"381","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5968-1814","authenticated-orcid":false,"given":"Kunal","family":"Gharat","sequence":"first","affiliation":[{"name":"Leibniz Institute on Aging - Fritz Lipmann Institute 1 , Jena, Germany"},{"name":"Institute of Biochemistry and Biophysics, Friedrich Schiller University 2 , Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4990-2497","authenticated-orcid":false,"given":"Janine","family":"Kirstein","sequence":"additional","affiliation":[{"name":"Leibniz Institute on Aging - Fritz Lipmann Institute 1 , Jena, Germany"},{"name":"Institute of Biochemistry and Biophysics, Friedrich Schiller University 2 , Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"2026100103073134900_RSTB20250269C1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"Macdonald","year":"1993","journal-title":"Cell"},{"key":"2026100103073134900_RSTB20250269C2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.neuro.23.1.217","article-title":"Glutamine repeats and neurodegeneration","volume":"23","author":"Zoghbi","year":"2000","journal-title":"Annu. 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