{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T02:03:42Z","timestamp":1772071422763,"version":"3.50.1"},"reference-count":3,"publisher":"The Royal Society","issue":"873","license":[{"start":{"date-parts":[[1946,12,3]],"date-time":"1946-12-03T00:00:00Z","timestamp":-728352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1946,12,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Three bacteriophages (S-13, C-36 and Staph-K) were irradiated by \u03b3-rays, X -rays and \u03b1-rays. The survival curves were exponential, and the effect of a given dose was independent of the exposure time. For any given phage the inactivation doses of the three radiations increased in the order \u03b3-rays, X -rays, \u03b1-rays, while for any given radiation the inactivation doses of the three phages diminished in the order S-13, C-36, Staph-K, which is the order of increasing size. These observations lead to the conclusion that a single ionization suffices to inactivate a phage particle. In the case of the smallest phage investigated (S-13) this ionization is effective wherever in the particle it is produced, and reasons are given for concluding from this fact that S-13 is a macromolecular type of virus analogous to the crystallizable plant viruses. In the case of the larger phages (C-36 and Staph-K ), while a single ionization can in\u00ad activate a phage particle it is not sufficient for it to be produced anywhere in the phage particle; to be effective it must be produced in a more restricted region. It is suggested that this radiosensitive region constitutes the genetical material of the phage, and on the basis of this differentiation into genetic and non-genetic material these phages are regarded as primitive single-celled organisms rather than macromolecules.<\/jats:p>","DOI":"10.1098\/rspb.1946.0023","type":"journal-article","created":{"date-parts":[[2006,12,18]],"date-time":"2006-12-18T18:22:58Z","timestamp":1166466178000},"page":"434-444","source":"Crossref","is-referenced-by-count":9,"title":["Experiments on the inactivation of bacteriophage by radiations, and their bearing on the nature of bacteriophage"],"prefix":"10.1098","volume":"133","author":[{"given":"D. E.","family":"Lea","sequence":"first","affiliation":[]},{"given":"M. H.","family":"Salaman","sequence":"additional","affiliation":[{"name":"From the Strangeways Laboratory, Cambridge"}]}],"member":"175","reference":[{"key":"p_1","unstructured":"Curie P . 1935 R adioactivite.P a ris: H e rm a n n e t Cie."},{"key":"p_2","unstructured":"D rey er G. & C am pbell-R enton M. L . 1933 J . P ath. B a d . 36 399."},{"key":"p_3","unstructured":"E Ifo rd W . J . 1938 I n D oerr R . & H ollauer C. S pringer. der V ien n a:"}],"container-title":["Proceedings of the Royal Society of London. Series B - Biological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rspb.1946.0023","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/rspb\/article-pdf\/133\/873\/434\/153767\/rspb.1946.0023.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/royalsocietypublishing.org\/rspb\/article-pdf\/133\/873\/434\/153767\/rspb.1946.0023.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T01:43:45Z","timestamp":1772070225000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/rspb\/article\/133\/873\/434\/29496\/Experiments-on-the-inactivation-of-bacteriophage"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1946,12,3]]},"references-count":3,"journal-issue":{"issue":"873","published-print":{"date-parts":[[1946,12,3]]}},"URL":"https:\/\/doi.org\/10.1098\/rspb.1946.0023","relation":{},"ISSN":["0080-4649","2053-9193"],"issn-type":[{"value":"0080-4649","type":"print"},{"value":"2053-9193","type":"electronic"}],"subject":[],"published":{"date-parts":[[1946,12,3]]}}}