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Most genes within 25\u00a0kb of each terminus are transcribed outwards towards the terminus, whereas genes within the centre of the genome are transcribed from either DNA strand. The central region of the genome contains genes that are highly conserved in other OPVs and 87 of these are conserved in all sequenced chordopoxviruses. In contrast, genes towards either terminus are more variable and encode proteins involved in host range, virulence or immunomodulation. In some cases, these are broken versions of genes found in other OPVs. The relationship of CMPV to other OPVs was analysed by comparisons of DNA and predicted protein sequences, repeats within the ITRs and arrangement of ORFs within the terminal regions. Each comparison gave the same conclusion: CMPV is the closest known virus to variola virus, the cause of smallpox.<\/jats:p>","DOI":"10.1099\/0022-1317-83-4-855","type":"journal-article","created":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T15:45:40Z","timestamp":1440603940000},"page":"855-872","source":"Crossref","is-referenced-by-count":141,"title":["The sequence of camelpox virus shows it is most closely related to variola virus, the cause of smallpox"],"prefix":"10.1099","volume":"83","author":[{"given":"Caroline","family":"Gubser","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Division of Investigative Science, Faculty of Medicine, Imperial College, St Mary\u2019s Campus, Norfolk Place, London W2 1PG, UK2"},{"name":"Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey 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