{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:25:14Z","timestamp":1791185114597,"version":"4.1.0"},"reference-count":63,"publisher":"Microbiology Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,4,1]]},"DOI":"10.1099\/00221287-148-4-923","type":"journal-article","created":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T16:20:40Z","timestamp":1440606040000},"page":"923-932","source":"Crossref","is-referenced-by-count":222,"title":["Genetically programmed autoinducer destruction reduces virulence gene expression and swarming motility in Pseudomonas aeruginosa PAO1 The GenBank accession number for the aiiA nucleotide sequence is AF397400. The GenBank accession numbers for the nucleotide sequences of the 16S rRNA genes of strains A23 and A24 are AF397398 and AF397399."],"prefix":"10.1099","volume":"148","author":[{"given":"Cornelia","family":"Reimmann","sequence":"first","affiliation":[{"name":"Laboratoire de Biologie Microbienne, Universit\u00e9 de Lausanne, CH-1015 Lausanne, Switzerland1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Ginet","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Microbienne, Universit\u00e9 de Lausanne, CH-1015 Lausanne, Switzerland1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Michel","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Microbienne, Universit\u00e9 de Lausanne, CH-1015 Lausanne, Switzerland1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Keel","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Microbienne, Universit\u00e9 de Lausanne, CH-1015 Lausanne, Switzerland1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Michaux","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Microbienne, Universit\u00e9 de Lausanne, CH-1015 Lausanne, Switzerland1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viji","family":"Krishnapillai","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Microbienne, Universit\u00e9 de Lausanne, CH-1015 Lausanne, Switzerland1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Zala","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pflanzenwissenschaften\/Phytopathologie, ETH Z\u00fcrich, CH-8092 Z\u00fcrich, Switzerland2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Heurlier","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Microbienne, Universit\u00e9 de Lausanne, CH-1015 Lausanne, Switzerland1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Triandafillu","sequence":"additional","affiliation":[{"name":"IATE-P\u00e9dologie, EPFL, CH 1015 Lausanne, Switzerland3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hauke","family":"Harms","sequence":"additional","affiliation":[{"name":"IATE-P\u00e9dologie, EPFL, CH 1015 Lausanne, Switzerland3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"D\u00e9fago","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pflanzenwissenschaften\/Phytopathologie, ETH Z\u00fcrich, CH-8092 Z\u00fcrich, Switzerland2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Haas","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Microbienne, Universit\u00e9 de Lausanne, CH-1015 Lausanne, Switzerland1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1128\/IAI.39.1.198-201.1983","article-title":"Evaluation of Pseudomonas aeruginosa exotoxin A and elastase as virulence factors in acute lung infection","volume":"39","author":"Blackwood","year":"1983","journal-title":"Infect Immun"},{"key":"R2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1139\/m80-022","article-title":"A function of Pseudomonas aeruginosa PAO pili: twitching motility","volume":"26","author":"Bradley","year":"1980","journal-title":"Can J Microbiol"},{"key":"R3","doi-asserted-by":"crossref","first-page":"7155","DOI":"10.1128\/JB.177.24.7155-7163.1995","article-title":"Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family","volume":"177","author":"Brint","year":"1995","journal-title":"J Bacteriol"},{"key":"R4","first-page":"113","article-title":"Role of reactive oxygen species in Pseudomonas infection. In Pseudomonas aeruginosa: the Opportunist. Pathogenesis and Disease","author":"Britigan","year":"1993"},{"key":"R5","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1139\/m75-088","article-title":"Hydrogen cyanide, a secondary metabolite of Pseudomonas aeruginosa","volume":"21","author":"Castric","year":"1975","journal-title":"Can J Microbiol"},{"key":"R6","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1094\/MPMI.1998.11.11.1119","article-title":"Production of acyl-homoserine lactone quorum-sensing signals by Gram-negative plant-associated bacteria","volume":"11","author":"Cha","year":"1998","journal-title":"Mol Plant\u2013Microbe Interact"},{"key":"R7","doi-asserted-by":"crossref","first-page":"441","DOI":"10.7164\/antibiotics.46.441","article-title":"Autoregulation of carbapenem biosynthesis in Erwinia carotovora by analogues of N- (3-oxohexanoyl)-l-homoserine lactone","volume":"46","author":"Chhabra","year":"1993","journal-title":"J Antibiot"},{"key":"R8","doi-asserted-by":"crossref","first-page":"11213","DOI":"10.1016\/S0040-4020(01)81808-1","article-title":"New halogenated furanones from the marine alga Delisea pulchra","volume":"49","author":"de Nys","year":"1993","journal-title":"Tetrahedron"},{"key":"R9","doi-asserted-by":"crossref","first-page":"9878","DOI":"10.1093\/nar\/16.20.9878","article-title":"A one-tube plasmid DNA mini-preparation suitable for sequencing","volume":"16","author":"Del Sal","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"R10","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1073\/pnas.97.7.3526","article-title":"AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora","volume":"97","author":"Dong","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"R11","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/35081101","article-title":"Quenching quorum-sensing-dependent bacterial infection by an N -acyl homoserine lactonase","volume":"411","author":"Dong","year":"2001","journal-title":"Nature"},{"key":"R12","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1128\/JB.172.2.884-900.1990","article-title":"Identification and characterization of genes for a second anthranilate synthase in Pseudomonas aeruginosa : interchangeability of the two anthranilate synthases and evolutionary implications","volume":"172","author":"Essar","year":"1990","journal-title":"J Bacteriol"},{"key":"R13","first-page":"221","article-title":"High efficiency electroporation of Pseudomonas aeruginosa using frozen cell suspensions","volume":"70","author":"Farinha","year":"1990","journal-title":"FEMS Microbiol Lett"},{"key":"R14","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1128\/JB.77.6.776-782.1959","article-title":"On the biosynthesis of pyocyanine","volume":"77","author":"Frank","year":"1959","journal-title":"J Bacteriol"},{"key":"R15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1369-5274(98)80009-X","article-title":"Self perception in bacteria: quorum sensing with acylated homoserine lactones","volume":"1","author":"Fuqua","year":"1998","journal-title":"Curr Opin Microbiol"},{"key":"R16","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1128\/JB.183.21.6207-6214.2001","article-title":"Pseudomonas aeruginosa PAO1 kills Caenorhabditis elegans by cyanide poisoning","volume":"183","author":"Gallagher","year":"2001","journal-title":"J Bacteriol"},{"key":"R17","doi-asserted-by":"crossref","first-page":"6618","DOI":"10.1128\/JB.178.22.6618-6622.1996","article-title":"Eukaryotic interference with homoserine lactone-mediated prokaryotic signaling","volume":"178","author":"Givskov","year":"1996","journal-title":"J Bacteriol"},{"key":"R18","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1128\/JB.181.5.1623-1629.1999","article-title":"Roles of Pseudomonas aeruginosa las and rhl quorum-sensing system in control of twitching motility","volume":"181","author":"Glessner","year":"1999","journal-title":"J Bacteriol"},{"key":"R19","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1128\/MMBR.36.4.478-503.1972","article-title":"Bacterial surface translocation: a survey and a classification","volume":"36","author":"Henrichsen","year":"1972","journal-title":"Bacteriol Rev"},{"key":"R20","first-page":"572","article-title":"Genetic recombination in Pseudomonas aeruginosa","volume":"13","author":"Holloway","year":"1955","journal-title":"J Gen Microbiol"},{"key":"R21","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1128\/iai.29.3.1028-1033.1980","article-title":"Production and properties of heat-stable extracellular hemolysin from Pseudomonas aeruginosa","volume":"29","author":"Johnson","year":"1980","journal-title":"Infect Immun"},{"key":"R22","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1016\/S0960-894X(99)00626-5","article-title":"Novel synthetic analogs of the Pseudomonas autoinducer","volume":"9","author":"Kline","year":"1999","journal-title":"Bioorg Med Chem Lett"},{"key":"R23","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1128\/JB.173.13.4212-4219.1991","article-title":"Hydrocarbon assimilation and biosurfactant production in Pseudomonas aeruginosa mutants","volume":"173","author":"Koch","year":"1989","journal-title":"J Bacteriol"},{"key":"R24","doi-asserted-by":"crossref","first-page":"5990","DOI":"10.1128\/JB.182.21.5990-5996.2000","article-title":"Swarming of Pseudomonas aeruginosa is dependent on cell-cell signaling and requires flagella and pili","volume":"182","author":"Ko\u0308hler","year":"2000","journal-title":"J Bacteriol"},{"key":"R25","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1128\/JB.178.4.971-976.1996","article-title":"Modulation of luminescence operon expression by N -octanoyl-l-homoserine lactone in ainS mutants of Vibrio fischeri","volume":"178","author":"Kuo","year":"1996","journal-title":"J Bacteriol"},{"key":"R26","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/35081216","article-title":"Quieting the raucous crowd","volume":"411","author":"Leadbetter","year":"2001","journal-title":"Nature"},{"key":"R27","doi-asserted-by":"crossref","first-page":"6921","DOI":"10.1128\/JB.182.24.6921-6926.2000","article-title":"Metabolism of acyl-homoserine lactone quorum-sensing signals by Variovorax paradoxus","volume":"182","author":"Leadbetter","year":"2000","journal-title":"J Bacteriol"},{"key":"R28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0092-8674(00)80958-7","article-title":"Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa\u2013Caenorhabditis elegans pathogenesis model","volume":"96","author":"Mahajan-Miklos","year":"1999","journal-title":"Cell"},{"key":"R29","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1099\/13500872-145-2-283","article-title":"Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein","volume":"145","author":"Manefield","year":"1999","journal-title":"Microbiology"},{"key":"R30","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1128\/AEM.66.5.2079-2084.2000","article-title":"Inhibition of luminescence and virulence in the tiger prawn ( Penaeus monodon ) pathogen Vibrio harveyi by intercellular signal antagonists","volume":"66","author":"Manefield","year":"2000","journal-title":"Appl Environ Microbiol"},{"key":"R31","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1094\/PHYTO.1998.88.7.678","article-title":"Salicylic acid biosynthetic genes expressed in Pseudomonas fluorescens strain P3 improve the induction of systemic resistance in tobacco against tobacco necrosis virus","volume":"88","author":"Maurhofer","year":"1998","journal-title":"Phytopathology"},{"key":"R32","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1099\/00221287-143-12-3703","article-title":"Quorum sensing and Chromobacterium violaceum : exploitation of violacein production and inhibition for the detection of N -acylhomoserine lactones","volume":"143","author":"McClean","year":"1997","journal-title":"Microbiology"},{"key":"R33","doi-asserted-by":"crossref","first-page":"6424","DOI":"10.1073\/pnas.92.14.6424","article-title":"Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa","volume":"92","author":"Ochsner","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R34","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1365-2958.1998.01062.x","article-title":"Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development","volume":"30","author":"O\u2019Toole","year":"1998","journal-title":"Mol Microbiol"},{"key":"R35","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1126\/science.8493556","article-title":"Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication","volume":"260","author":"Passador","year":"1993","journal-title":"Science"},{"key":"R36","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1128\/JB.178.20.5995-6000.1996","article-title":"Functional analysis of the Pseudomonas aeruginosa autoinducer PAI","volume":"178","author":"Passador","year":"1996","journal-title":"J Bacteriol"},{"key":"R37","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1073\/pnas.91.1.197","article-title":"Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes","volume":"91","author":"Pearson","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R38","doi-asserted-by":"crossref","first-page":"5756","DOI":"10.1128\/JB.179.18.5756-5767.1997","article-title":"Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes","volume":"179","author":"Pearson","year":"1997","journal-title":"J Bacteriol"},{"key":"R39","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1128\/IAI.68.7.4331-4334.2000","article-title":"Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection","volume":"68","author":"Pearson","year":"2000","journal-title":"Infect Immun"},{"key":"R40","first-page":"147","article-title":"Quorum sensing in Pseudomonas aeruginosa","volume-title":"Cell\u2013Cell Signaling in Bacteria","author":"Pesci","year":"1999"},{"key":"R41","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1128\/JB.179.10.3127-3132.1997","article-title":"Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa","volume":"179","author":"Pesci","year":"1997","journal-title":"J Bacteriol"},{"key":"R42","doi-asserted-by":"crossref","first-page":"6940","DOI":"10.1128\/JB.182.24.6940-6949.2000","article-title":"Transcriptional control of the hydrogen cyanide biosynthetic genes hcnABC by the anaerobic regulator ANR and the quorum-sensing regulators LasR and RhlR in Pseudomonas aeruginosa","volume":"182","author":"Pessi","year":"2000","journal-title":"J Bacteriol"},{"key":"R43","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1128\/IAI.44.1.38-40.1984","article-title":"Role of pili in the adherence of Pseudomonas aeruginosa to injured tracheal epithelium","volume":"44","author":"Ramphal","year":"1984","journal-title":"Infect Immun"},{"key":"R44","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1128\/IAI.59.4.1307-1311.1991","article-title":"Adhesion of Pseudomonas aeruginosa pilin-deficient mutants to mucin","volume":"59","author":"Ramphal","year":"1991","journal-title":"Infect Immun"},{"key":"R45","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.1073\/pnas.060030097","article-title":"Inorganic polyphosphate is needed for swimming, swarming, and twitching motilities of Pseudomonas aeruginosa","volume":"97","author":"Rashid","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R46","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1128\/AEM.59.10.3255-3265.1993","article-title":"Bacterial adhesion under static and dynamic conditions","volume":"59","author":"Rijnaarts","year":"1993","journal-title":"Appl Environ Microbiol"},{"key":"R47","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/S1286-4579(00)01327-7","article-title":"The role of quorum sensing in the in vivo virulence of Pseudomonas aeruginosa","volume":"2","author":"Rumbaugh","year":"2000","journal-title":"Microbes Infect"},{"key":"R48","volume-title":"Molecular Cloning: a Laboratory Manual","author":"Sambrook","year":"1989"},{"key":"R49","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1348-0421.1988.tb01372.x","article-title":"Role of pili in the pathogenesis of Pseudomonas aeruginosa burn infections","volume":"32","author":"Sato","year":"1988","journal-title":"Microbiol Immunol"},{"key":"R50","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1021\/es980191u","article-title":"Bacterial accumulation at the air-water interface","volume":"32","author":"Scha\u0308fer","year":"1998","journal-title":"Environ Sci Technol"},{"key":"R51","doi-asserted-by":"crossref","first-page":"6036","DOI":"10.1073\/pnas.94.12.6036","article-title":"Detecting and characterizing N -acyl-homoserine lactone signal molecules by thin-layer chromatography","volume":"94","author":"Shaw","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"R52","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF02438660","article-title":"New method for detecting rhamnolipids excreted by Pseudomonas species during growth on mineral agar","volume":"5","author":"Siegmund","year":"1991","journal-title":"Biotechnol Tech"},{"key":"R53","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/nbt1183-784","article-title":"A broad host range mobilization system for in vitro genetic engineering: transposon mutagenesis in Gram negative bacteria","volume":"1","author":"Simon","year":"1983","journal-title":"Biotechnology"},{"key":"R54","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1017\/S0016672300014294","article-title":"A mutant sex factor of Pseudomonas aeruginosa","volume":"19","author":"Stanisich","year":"1972","journal-title":"Genet Res"},{"key":"R55","first-page":"291","article-title":"N -Acylhomoserine lactones and quorum sensing in proteobacteria","volume-title":"Cell\u2013Cell Signaling In Bacteria","author":"Swift","year":"1999"},{"key":"R56","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1128\/IAI.63.4.1278-1285.1995","article-title":"Role of Pseudomonas aeruginosa pili in acute pulmonary infection","volume":"63","author":"Tang","year":"1995","journal-title":"Infect Immun"},{"key":"R57","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-1119(91)90365-I","article-title":"New pUC-derived cloning vectors with different selectable markers and DNA replication origins","volume":"100","author":"Vieira","year":"1991","journal-title":"Gene"},{"key":"R58","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/j.1460-2075.1989.tb03384.x","article-title":"Cyanide production by Pseudomonas fluorescens helps suppress back root rot of tobacco under gnotobiotic conditions","volume":"8","author":"Voisard","year":"1989","journal-title":"EMBO J"},{"key":"R59","article-title":"The coordinate regulation of twitching motility and other virulence factors in Pseudomonas aeruginosa","author":"Whitchurch","year":"2001","journal-title":"Pseudomonas Meeting 2001, Brussels, Abstract no. 7"},{"key":"R60","doi-asserted-by":"crossref","first-page":"13904","DOI":"10.1073\/pnas.96.24.13904","article-title":"Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa","volume":"96","author":"Whiteley","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"R61","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1098\/rstb.2000.0607","article-title":"Quorum sensing and the population-dependent control of virulence","volume":"355","author":"Williams","year":"2000","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci"},{"key":"R62","doi-asserted-by":"crossref","first-page":"9427","DOI":"10.1073\/pnas.92.20.9427","article-title":"Multiple N -acyl-l-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa","volume":"92","author":"Winson","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"R63","doi-asserted-by":"crossref","first-page":"5398","DOI":"10.1128\/JB.180.20.5398-5405.1998","article-title":"Analogs of the autoinducer 3-oxooctanoyl-homoserine lactone strongly inhibit activity of the TraR protein of Agrobacterium tumefaciens","volume":"180","author":"Zhu","year":"1998","journal-title":"J Bacteriol"}],"container-title":["Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/micro\/10.1099\/00221287-148-4-923?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T23:43:06Z","timestamp":1653090186000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/micro\/10.1099\/00221287-148-4-923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,1]]},"references-count":63,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4,1]]}},"URL":"https:\/\/doi.org\/10.1099\/00221287-148-4-923","relation":{},"ISSN":["1350-0872","1465-2080"],"issn-type":[{"value":"1350-0872","type":"print"},{"value":"1465-2080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4,1]]}}}