{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:41:09Z","timestamp":1791906069252,"version":"4.3.4"},"reference-count":20,"publisher":"Microbiology Society","issue":"6","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:p>\n                  <jats:bold>Introduction.<\/jats:bold> Dermatophytosis caused by <jats:italic>Nannizzia gypsea<\/jats:italic> formerly <jats:italic>Microsporum gypse<\/jats:italic>\n                  <jats:italic>um<\/jats:italic> is rare in occurrence due to its geophilic adaptation and weak pathogenic potential in establishing infection in humans. The taxonomical status of <jats:italic>N. gypsea<\/jats:italic> has been controversial over the years and has now reached a concordance among mycologists. Innumerable reports of <jats:italic>N. gypsea<\/jats:italic> causing widespread infection in human immunodeficiency virus patients trails them as an important agent of consideration in an immunocompromised host. There have been sporadic reports of <jats:italic>N. gypsea<\/jats:italic> causing glabrous skin tinea and onychomycosis in healthy patients and the prevalence reports gravitate around 1\u20136.5 \u200a%. A variety of non-anthropophilic dermatophytes including novel species have now been implicated in causing dermatophytosis reflecting the era of crux changes in the epidemiology.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Case report.<\/jats:bold> We present a case of chronic dermatophytosis in a 22-year-old healthy Indian with a history of contact with a dog and soil and other factors favouring dermatophytosis. Conventional and molecular sequencing established the isolate as <jats:italic>N. gypsea<\/jats:italic>. Antifungal susceptibility test revealed a higher MIC of griseofulvin and lower MIC to azoles and terbinafine. The patient had complete clinical resolution following administration of oral terbinafine.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion.<\/jats:bold> Amidst the hyper-endemic-like scenario of tinea in India, this case report stands as a unique example of a patient infected with <jats:italic>N. gypsea<\/jats:italic> showing complete clinical resolution using terbinafine. Studies implicating <jats:italic>N. gypsea<\/jats:italic> in an immunocompetent host are rare and there is a need for more studies on geophilic dermatophytes causing tinea in the man for laying down effective preventive measures.<\/jats:p>","DOI":"10.1099\/acmi.0.000022","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T16:13:19Z","timestamp":1556899999000},"source":"Crossref","is-referenced-by-count":7,"title":["Naive tinea corporis et cruris in an Immunocompetent adult caused by a geophile Nannizzia gypsea susceptible to Terbinafine\u2013Rarity in the current scenario of Dermatophytosis in India"],"prefix":"10.1099","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4897-335X","authenticated-orcid":false,"given":"Hari Pankaj","family":"Vanam","sequence":"first","affiliation":[{"name":"Mycology Division, Department of Microbiology, Bhaskar Medical College and General hospital, Bhaskar Nagar, Yenkapally, Moinabad, R.R. District, Telangana 500 075, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalyani","family":"Mohanram","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Saveetha Medical College, Thandalam, Chennai, Tamilnadu 602 105, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Siva Rami","family":"Reddy","sequence":"additional","affiliation":[{"name":"Dermatology, Department of DVL, Bhaskar Medical College and General hospital, Bhaskar Nagar, Yenkapally, Moinabad, R.R. District, Telangana 500 075, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhu","family":"Rengasamy","sequence":"additional","affiliation":[{"name":"Dermatology (Mycology), Madras Medical College, Chennai 600 003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9097-9253","authenticated-orcid":false,"given":"Shivaprakash Mandya","family":"Rudramurthy","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-016-0073-9"},{"key":"R2","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1080\/00362176785190661","article-title":"Little GN: differences in pathogencity between M. gypseum and M. fulvum","volume":"5","author":"Gordon","year":"1967","journal-title":"Sabouraudia"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-016-0066-8"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.70700"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1080\/00362177085190791"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-017-0194-9"},{"key":"R7","first-page":"181","article-title":"Dermatophytic profile of Jaipur (Rajasthan)","volume":"14","author":"Iyer","year":"1995","journal-title":"Anc Sci Life"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myy099"},{"key":"R9","first-page":"14","article-title":"Nannizzia graeserae sp. nov., a new dermatophyte of geophilic clade isolated from vicinity of a barbershop in India","volume":"50","author":"Sharma","year":"2018","journal-title":"MSI (Kavaka)"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.IJD_206_17"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02522-17"},{"key":"R12","article-title":"Dermatophytes its sequences database"},{"key":"R13","volume-title":"Laboratory Handbook of Dermatophytes a Clinical Guide and Laboratory Handbook of Dermatophytes and Other Filamentous Fungi from Skin, Hair, and Nails","author":"Kane","year":"1997"},{"key":"R14","volume-title":"Medical Mycology: The pathogenic Fungi and the Pathogenic Actinomycetes","author":"Rippon","year":"1988"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.8.2.240"},{"key":"R16","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1439-0507.1989.tb02177.x","article-title":"[Ecology, epidemiology and clinical symptomatology of Microsporum gypseum infections]","volume":"32","author":"Ginter","year":"1989","journal-title":"Mycoses"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myu088"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1016\/S0174-3031(84)80077-3"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2017.12.001"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2006.01204.x"}],"container-title":["Access Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/acmi\/10.1099\/acmi.0.000022?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T05:31:03Z","timestamp":1702618263000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/acmi\/10.1099\/acmi.0.000022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,1]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,8,1]]}},"URL":"https:\/\/doi.org\/10.1099\/acmi.0.000022","relation":{},"ISSN":["2516-8290"],"issn-type":[{"value":"2516-8290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,1]]}}}