{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T01:47:29Z","timestamp":1775008049523,"version":"3.50.1"},"reference-count":30,"publisher":"Microbiology Society","issue":"7","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:p>\n                  <jats:bold>Introduction.<\/jats:bold> We describe a case of acute cytomegalovirus (CMV) infection complicated by acquired antiphospholipid antibodies and splenic thrombi. We discuss the associations between CMV infection and thrombosis risk and correlation with antiphospolipid antibodies.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Case presentation.<\/jats:bold> A previously healthy 32-year-old woman is hospitalized for acute abdominal pain and fever and found to have multiple splenic infarcts on an abdominal computed tomography (CT) scan. An infectious work-up is negative except for acute CMV, and a hypercoagulable work-up is only positive for antiphospholipid antibodies. The patient is discharged and placed on anti-coagulation therapy for 6 months.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion.<\/jats:bold> Co-incident thrombosis and antiphospholipid antibody syndrome can occur with acute viral infections, including CMV. We discuss the viral infection-associated increased risk of developing blood clots and antiphospholipid antibodies as being either correlative with or causative of viral-induced thrombosis.<\/jats:p>","DOI":"10.1099\/acmi.0.000032","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T15:12:52Z","timestamp":1560179572000},"source":"Crossref","is-referenced-by-count":4,"title":["Antiphospholipid antibody syndrome with thrombotic splenic infarcts associated with acute cytomegalovirus infection"],"prefix":"10.1099","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4297-0043","authenticated-orcid":false,"given":"Christopher","family":"Denham","sequence":"first","affiliation":[{"name":"Trinity School of Medicine, Kingstown, St.Vincent and the Grenadines, West Indies"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3463-8729","authenticated-orcid":false,"given":"Ginger","family":"Tissier","sequence":"additional","affiliation":[{"name":"Trinity School of Medicine, Kingstown, St.Vincent and the Grenadines, West Indies"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3659-6654","authenticated-orcid":false,"given":"Amit","family":"Golding","sequence":"additional","affiliation":[{"name":"Baltimore VA\/VAMHCS and University of Maryland School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312460722"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.655"},{"key":"R3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.pcl.2012.12.008","article-title":"Congenital cytomegalovirus infection: new prospects for Prevention and therapy: for pediatric clinics of North America: advances in evaluation, diagnosis and treatment of pediatric infectious disease","volume":"60","author":"Swanson","year":"2013","journal-title":"Pediatric clinics of North America"},{"key":"R4","first-page":"343","article-title":"Cytomegalovirus infection in immunosuppressed patients after kidney transplantation","volume":"89","author":"Luscalov","year":"2016","journal-title":"Clujul Medical"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01618.x"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1086\/374664"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2010.11.006"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70355-1"},{"key":"R9","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1055\/s-0037-1613846","article-title":"Venous thromboembolism and associated high plasma factor VIII levels: linked to cytomegalovirus infection?","volume":"83","author":"Schambeck","year":"2000","journal-title":"Thromb Haemost"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1186\/1476-0711-4-11"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.25.13510"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-08-0523"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00011-12"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.4.2211-2220.2005"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2006.03.031"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.2.197"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1191\/096120399678841034"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-112-9-682"},{"key":"R19","first-page":"557","article-title":"High prevalence of anti-cardiolipin and other autoantibodies in a healthy elderly population","volume":"69","author":"Mannoussakis","year":"1987","journal-title":"Clin Exp Immunology"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.5.388"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(86)90046-2"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0212337"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310818"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1993.tb05950.x"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(94)90037-X"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1002\/art.10187"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3498-0"},{"key":"R28","article-title":"First-line, Non-criterial antiphospholipid antibody testing for the diagnosis of antiphospholipid syndrome in clinical practice: a combination of anti-beta2-glycoprotein I domain I and phosphatidylserine-dependent Antiprothrombin antibodies","author":"Nakamura","year":"2017","journal-title":"Arthritis Care Res"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2016-0676"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316660203"}],"container-title":["Access Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/acmi\/10.1099\/acmi.0.000032?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T05:28:34Z","timestamp":1702618114000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/acmi\/10.1099\/acmi.0.000032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,1]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,9,1]]}},"URL":"https:\/\/doi.org\/10.1099\/acmi.0.000032","relation":{},"ISSN":["2516-8290"],"issn-type":[{"value":"2516-8290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,1]]}}}