{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T17:44:24Z","timestamp":1778175864766,"version":"3.51.4"},"reference-count":20,"publisher":"Microbiology Society","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:p>To better understand the prevalence of fluoroquinolone-resistant <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.3093\" xlink:type=\"simple\">Escherichia coli<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> among sheltered companion animals, we conducted a screening study of 38 dogs and 78 cats and investigated the resistance mechanisms and characteristics of the isolates. Fluoroquinolone-resistant <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.3093\" xlink:type=\"simple\">E. coli<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> was detected in 18 dogs (47.4\u200a%) and 14 cats (17.9\u200a%). The isolates carried one to four mutations in the <jats:italic>gyr<\/jats:italic>A, <jats:italic>par<\/jats:italic>C and <jats:italic>par<\/jats:italic>E genes of the quinolone resistance-determining region, and the number of mutations was proportional to the MIC for ciprofloxacin. For plasmid-mediated quinolone resistance, <jats:italic>aac-(6\u2032)-Ib-cr<\/jats:italic> was detected in nine isolates, <jats:italic>qnr<\/jats:italic>S in five isolates and <jats:italic>qnr<\/jats:italic>B in one isolate. A relationship between the presence of these genes and MIC for ciprofloxacin was not apparent. Statistical analysis indicated that fluoroquinolone-resistant <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.3093\" xlink:type=\"simple\">E. coli<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> was widely distributed among sheltered companion animals with various attributes. This may relate to the wide dissemination of fluoroquinolone resistance among humans and other animals in Japan.<\/jats:p>","DOI":"10.1099\/acmi.0.000077","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T16:13:37Z","timestamp":1572970417000},"source":"Crossref","is-referenced-by-count":13,"title":["Prevalence and mechanisms of fluoroquinolone-resistant Escherichia coli among sheltered companion animals"],"prefix":"10.1099","volume":"2","author":[{"given":"Kaoru","family":"Umeda","sequence":"first","affiliation":[{"name":"Division of Microbiology, Osaka Institute of Public Health, 8-34, Tojo-cho, Tennoji-ku, Osaka 543-0026, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Hase","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Osaka Institute of Public Health, 8-34, Tojo-cho, Tennoji-ku, Osaka 543-0026, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Osaka Institute of Public Health, 8-34, Tojo-cho, Tennoji-ku, Osaka 543-0026, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Osaka Municipal Animal Care and Control Center, 2-5-74, Shibatani, Suminoe-ku, Osaka 559-0021, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Horimoto","sequence":"additional","affiliation":[{"name":"Osaka Municipal Animal Care and Control Center, 2-5-74, Shibatani, Suminoe-ku, Osaka 559-0021, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Osaka Institute of Public Health, 8-34, Tojo-cho, Tennoji-ku, Osaka 543-0026, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","volume-title":"Antimicrobial Resistance Global Report on Surveillance","year":"2014"},{"key":"R2"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000475"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00024"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2014.04.007"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000933"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2018.02.002"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2010.04.012"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.13-0144"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks514"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2014.01.019"},{"key":"R12","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing","year":"2019"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01093-07"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01051-08"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr172"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00139-10"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2016.0246"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03570.x"},{"key":"R19","first-page":"2014","article-title":"Report on the Japanese veterinary antimicrobial resistance monitoring system"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2012.11.077"}],"container-title":["Access Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/acmi\/10.1099\/acmi.0.000077?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T03:25:04Z","timestamp":1702610704000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/acmi\/10.1099\/acmi.0.000077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,1]]}},"URL":"https:\/\/doi.org\/10.1099\/acmi.0.000077","relation":{},"ISSN":["2516-8290"],"issn-type":[{"value":"2516-8290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,1]]}}}