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Based on previous studies, it was found that apoptosis and inflammation stimulation were among the most important mechanisms underlying HAM\/TSP. The present study provides an <jats:italic>in-silico<\/jats:italic> analysis of the microarray data related to HAM\/TSP patients. Expression changes of the genes responsible for cytotoxicity and apoptosis processes of HAM\/TSP patients and asymptomatic carriers were investigated. Expression of the genes involved in cytotoxicity and apoptosis in HAM\/TSP patients was decreased; hence, a model was proposed indicating that the spread of immune responses in HAM\/TSP may be due to expression of HTLV-1 virulence factors and the resistance of HTLV-1-infected cells to apoptosis.<\/jats:p>","DOI":"10.1099\/acmi.0.000088","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T18:25:18Z","timestamp":1579026318000},"source":"Crossref","is-referenced-by-count":2,"title":["Expression changes of cytotoxicity and apoptosis genes in HTLV-1-associated myelopathy\/tropical spastic paraparesis patients from the perspective of system virology"],"prefix":"10.1099","volume":"2","author":[{"given":"Kiarash","family":"Ghazvini","sequence":"first","affiliation":[{"name":"Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"},{"name":"Antimicrobial Resistance Research Center, Mashhad University 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