{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:02:31Z","timestamp":1792598551777,"version":"4.5.0"},"reference-count":25,"publisher":"Microbiology Society","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"\n \n \n Weissella confusa<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n is a Gram-positive coccus and a commensal bacterium of the human gastrointestinal tract with a potential to cause invasive infections. We report the presence of\n \n \n W. confusa<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n in the blood of a 25-year-old male patient with Crohn\u2019s disease, short bowel syndrome treated with home parenteral nutrition, and a history of recurrent bloodstream infections, admitted to our hospital with fever and malaise. A polymicrobial culture of\n \n \n W. confusa<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n and\n \n \n Aeromonas hydrophila<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n was identified from blood, for which treatment with meropenem and metronidazole was initiated. The literature was searched for previous cases of infection with\n \n \n W. confusa<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n . In total, 14 reports describing infection of 28 patients were found, most cases presenting with bacteremia. The previous reports have described variable susceptibility to antibiotics; however, all were reported to be vancomycin resistant. Because of its similarities to other vancomycin-resistant cocci, isolates of\n \n \n W. confusa<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n might be difficult to identify with traditional methods. Infection may be facilitated by its natural vancomycin resistance, leading to severe infection in hosts with underlying diseases. We describe the treatment of previous cases of infection and suggest treatment methods shown effective in other cases. Vancomycin is often used as treatment of infection with Gram-positive organisms, but this may need to be reevaluated, as several pathogenic bacteria are intrinsically vancomycin resistant. A review on reported treatments of bacteremia by\n \n \n W. confusa<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n suggests the use of daptomycin, amoxicillin-clavulanate or piperacillin\/tazobactam as recommendable antibiotic regimens.\n <\/jats:p>","DOI":"10.1099\/acmi.0.000119","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T11:17:17Z","timestamp":1585221437000},"source":"Crossref","is-referenced-by-count":17,"title":["A case report of polymicrobial bacteremia with Weissella confusa and comparison of previous treatment for successful recovery with a review of the literature"],"prefix":"10.1099","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2725-2078","authenticated-orcid":false,"given":"Malene Roed","family":"Spiegelhauer","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology, Copenhagen University Hospital (Rigshospitalet), Henrik Harpestrengs Vej, Copenhagen 2100, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melodi","family":"Yusibova","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Copenhagen University Hospital (Rigshospitalet), Henrik Harpestrengs Vej, Copenhagen 2100, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida Kirstine Bull","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Copenhagen University Hospital (Rigshospitalet), Blegdamsvej 9, 2100 Copenhagen 2100, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0483-5297","authenticated-orcid":false,"given":"Kristian Asp","family":"Fuglsang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Copenhagen University Hospital (Rigshospitalet), Blegdamsvej 9, 2100 Copenhagen 2100, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Copenhagen University Hospital (Rigshospitalet), Henrik Harpestrengs Vej, Copenhagen 2100, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif Percival","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Copenhagen University Hospital (Rigshospitalet), Henrik Harpestrengs Vej, Copenhagen 2100, 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