{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T05:47:20Z","timestamp":1785563240698,"version":"3.56.0"},"reference-count":88,"publisher":"Microbiology Society","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"\n Background.<\/jats:bold> The rapid spread of resistance among extended-spectrum \u03b2-lactamase (ESBL)-producing \n \n Enterobacteriaceae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> is a serious problem around the world. It results in serious clinical complications in humans and has become a global threat. Therefore, this systematic review and meta-analysis was aimed to estimate the pooled prevalence of ESBL-producing \n \n Enterobacteriaceae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> in different clinical samples in Ethiopia.<\/jats:p>\n \n Methods.<\/jats:bold> A systematic search was conducted on PubMed, Web of Science, Embase, Google Scholar and the Cochrane Library. All identified observational studies reporting the prevalence of ESBL-producing \n \n Enterobacteriaceae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> from clinical samples in Ethiopia were included. Four authors independently extracted data and analysed using R software version 3.6.1 and STATA statistical software version 13. A random-effects model was computed to estimate the pooled prevalence of ESBL-producing \n \n Enterobacteriaceae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> in Ethiopia.<\/jats:p>\n \n Results.<\/jats:bold> Of 142 articles reviewed, 14 studies that fulfilled the inclusion criteria were included in the meta-analysis. The pooled prevalence of ESBL-producing \n \n Enterobacteriaceae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> in the different clinical specimens in Ethiopia was 49\u200a% (95\u200a% CI: 39, 60). \n \n Klebsiella pneumoniae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> was the leading ESBL-producing \n \n Enterobacteriaceae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> followed by \n \n Escherichia coli<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> and \n \n Acinetobacter baumannii<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> with a prevalence of 74, 67 and 60\u200a%, respectively. ESBL-producing isolates showed a high rate of resistance to cefotaxime, ceftriaxone, ceftazidime, Amoxicillin clavulanic acid (AMC), ampicillin and aztreonam. The better options for the treatment of ESBL-producing \n \n Enterobacteriaceae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> are amikacin and Imipenem.<\/jats:p>\n \n Conclusion.<\/jats:bold> The magnitude of ESBL-producing \n \n Enterobacteriaceae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> in different clinical samples in Ethiopia is alarmingly high and represents a threat to human health. Hence, a coordinated effort needs to be implemented for the prevention and control of these \n \n Enterobacteriaceae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>.<\/jats:p>","DOI":"10.1099\/acmi.0.000195","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T15:26:40Z","timestamp":1611847600000},"source":"Crossref","is-referenced-by-count":22,"title":["The magnitude of extended-spectrum beta-lactamase- producing Enterobacteriaceae from clinical samples in Ethiopia: a systematic review and meta-analysis"],"prefix":"10.1099","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7083-7725","authenticated-orcid":false,"given":"Kuma","family":"Diriba","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Sciences, Health Science and Medical College, Dilla University, Dilla, 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