{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:08:11Z","timestamp":1747181291633,"version":"3.40.5"},"reference-count":19,"publisher":"Microbiology Society","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:p>Critically ill patients with coronavirus disease 2019 (COVID-19) are at risk of invasive pulmonary aspergillosis. The clinical manifestations of a superimposed fungal infection in those patients are difficult to underpin. This is compounded by the non-specific radiological findings associated with this infection and the challenges associated with performing bronchoscopy in COVID-19 patients. We would like to present two COVID-19 cases who developed secondary <jats:italic>Aspergillus<\/jats:italic> pulmonary infection in the intensive care unit as shown by respiratory cultures, serum galactomannan and radiological images. Despite advanced intensive care and use of antifungal agents, both patients died eventually. This report illustrates the negative impact of secondary Aspergillosis and calls for the need of increased awareness of COVID19-associated pulmonary aspergillosis.<\/jats:p>","DOI":"10.1099\/acmi.0.000201","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T14:33:09Z","timestamp":1613053989000},"source":"Crossref","is-referenced-by-count":6,"title":["Pulmonary aspergillosis in two COVID-19 patients from Kuwait"],"prefix":"10.1099","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7481-3587","authenticated-orcid":false,"given":"Khaled","family":"Alobaid","sequence":"first","affiliation":[{"name":"Mycology reference laboratory, Mubarak Al-Kabeer hospital, Jabriya, 46307, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beena","family":"Yousuf","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Adan Hospital, Hadiya, 64020, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman","family":"Al-Qattan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Adan Hospital, Hadiya, 64020, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zainab","family":"Muqeem","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Jaber Al Ahmad Hospital, South Surra, 23385, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3879-9829","authenticated-orcid":false,"given":"Nawaf","family":"Al-Subaie","sequence":"additional","affiliation":[{"name":"Department of intensive care unit, Ahmadi Hospital, Ahmadi, 61008, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.04.023"},{"key":"R2","article-title":"COVID-19-associated invasive pulmonary aspergillosis","volume":"Jun 1;10","author":"Rutsaert","year":"2020","journal-title":"Ann Intensive Care"},{"key":"R3","article-title":"Confronting and mitigating the risk of COVID-19 associated pulmonary aspergillosis (CapA)","volume":"2002554","author":"Armstrong-James","year":"2020","journal-title":"Eur Respir J"},{"key":"R4","first-page":"2526","article-title":"Acute respiratory distress syndrome: the Berlin definition","volume":"307","year":"2012","journal-title":"JAMA"},{"key":"R5","article-title":"COVID 19 Updates [Internet]. Ministry of health. State of Kuwait. [ live; cited 2020 Dec 11] Available from: https:\/\/corona.e.gov.kw\/en"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.3390\/jof6030115"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13135"},{"key":"R8","first-page":"30412","article-title":"Incidence of invasive pulmonary aspergillosis among critically ill COVID-19 patients","volume":"S1198-743X","author":"Lamoth","year":"2020","journal-title":"Clin Microbiol Infect"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06091-6"},{"key":"R10","article-title":"Epidemiology of invasive pulmonary aspergillosis among COVID-19 intubated patients: a prospective study","author":"Bartoletti","year":"2020","journal-title":"Clin Infect Dis"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30274-1"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(20)30027-6"},{"key":"R13","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/MCC.0000000000000637","article-title":"Diagnosing invasive pulmonary aspergillosis in ICU patients: putting the puzzle together","volume":"25","author":"Blot","year":"2019","journal-title":"Curr Opin Crit Care"},{"key":"R14","article-title":"2020 [cited 2020 17th June]. Available from: https:\/\/www.recoverytrial.net\/files\/recovery_dexamethasone_statement_160620_final.pdf"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2011.02044.x"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61069-2"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30628-0"},{"key":"R18","article-title":"The challenge of managing COVID-19 associated pulmonary aspergillosis [published online ahead of print, 2020 Aug 18]","author":"Br\u00fcggemann","year":"2020","journal-title":"Clin Infect Dis"},{"key":"R19","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmi.2018.01.002","article-title":"Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline","author":"Ullmann","year":"2018","journal-title":"Clin Microbiol Infect"}],"container-title":["Access Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/acmi\/10.1099\/acmi.0.000201?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:23:28Z","timestamp":1702599808000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/acmi\/10.1099\/acmi.0.000201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3,1]]}},"URL":"https:\/\/doi.org\/10.1099\/acmi.0.000201","relation":{},"ISSN":["2516-8290"],"issn-type":[{"type":"electronic","value":"2516-8290"}],"subject":[],"published":{"date-parts":[[2021,3,1]]}}}