{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:32:09Z","timestamp":1792801929805,"version":"4.5.0"},"reference-count":37,"publisher":"Microbiology Society","issue":"12","license":[{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,17]]},"abstract":"\n Background.<\/jats:bold>\n \n \n Streptococcus pneumoniae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> is the leading cause of community-acquired pneumonia (CAP) in adults. Ageing, chronic conditions and comorbidities are important risk factors for pneumococcal pneumonia.<\/jats:p>\n \n Purpose.<\/jats:bold> There is lack of data on the pneumococcal serotypes causing non-invasive pneumonia in India. This study aims to determine the prevalent pneumococcal serotypes causing non-invasive pneumonia, the associated comorbidities, and the coverage of both the available pneumococcal vaccines in India and conjugate vaccines that are currently undergoing clinical trials.<\/jats:p>\n \n Methods.<\/jats:bold> A total of 280\u2009subjects (aged >16\u2009years) who had clinical symptoms correlating with radiological findings for non-invasive bacteremic pneumonia and microbiological evidence of \n \n S. pneumoniae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> between 2018 and 2020 were included. The clinical, demographic, radiological and microbiological findings were retrieved from the Hospital Information System (HIS).<\/jats:p>\n \n Results.<\/jats:bold> The common serotypes in order of prevalence were 19F, 9V, 23F, 6B, 11A, 13, 34, 10A, 19A and 6A. The predominant non-vaccine serotypes were 13, 34, 35B, 31 and 16F. The associated radiological findings were pneumonic consolidation and multi-lobar involvement. Other coinfected bacterial pathogens included H. influenzae, S. aureus<\/jats:italic>, K. pneumoniae<\/jats:italic> and P. aeruginosa<\/jats:italic>.<\/jats:p>\n \n Conclusion.<\/jats:bold> The pneumococcal vaccines: PCV10\/GSK, PCV10\/SII, PCV13, PCV15, PCV20 and PPSV23 provide an overall serotype coverage of 36, 41, 47, 48, 61 and 69\u200a%, respectively of \n \n S. pneumoniae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> causing non-invasive pneumonia in South India. Increasing catch-up vaccination using PCV10(SII) in pre-school children could have a more significant impact on reducing pneumococcal pneumonia in adults (>50\u2009years) in terms of increased herd immunity at an affordable cost.<\/jats:p>","DOI":"10.1099\/acmi.0.000258","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T16:15:46Z","timestamp":1638893746000},"source":"Crossref","is-referenced-by-count":9,"title":["Pneumococcal serotypes causing non-invasive pneumonia in adults from a South Indian tertiary care hospital and the impact of the newer conjugate vaccines"],"prefix":"10.1099","volume":"3","author":[{"given":"Rosemol","family":"Varghese","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binesh Lal","family":"Yesudhason","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena Robinson","family":"Vimala","sequence":"additional","affiliation":[{"name":"Department of Radiology, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayyanraj","family":"Neeravi","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavipriya","family":"Anandhan","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavithra","family":"Baskar","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divyaa","family":"Elangovan","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abi","family":"Manesh","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7347-5723","authenticated-orcid":false,"given":"Prince","family":"James","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8662-4257","authenticated-orcid":false,"given":"Balaji","family":"Veeraraghavan","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30396-1"},{"key":"R2","first-page":"12","article-title":"Pneumococcal disease in older adults-an overview","volume":"63","author":"Ramasubramanian","year":"2015","journal-title":"J Assoc Physicians India"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.02.026"},{"key":"R4","first-page":"216","volume-title":"Pneumococcal Disease Burden from an Indian Perspective: Need for its Prevention in Pulmonology Practice","author":"Koul","year":"2019"},{"key":"R5","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1080\/21645515.2016.1264548","article-title":"Herd effects of child vaccination with pneumococcal conjugate vaccine against pneumococcal non-invasive community-acquired pneumonia: What is the evidence?","volume":"13","author":"van Werkhoven","year":"2017","journal-title":"Hum Vaccines Immunother"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwy219"},{"key":"R7","doi-asserted-by":"crossref","DOI":"10.4103\/ijmm.IJMM_19_320","article-title":"Pneumococcal conjugate vaccine rollout in India: Expectations and challenges","volume":"37","author":"Varghese","year":"2019","journal-title":"Indian J Med Microbiol"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.02.002"},{"key":"R9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.trivac.2016.04.004","article-title":"CAPiTA Study Group. 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