{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:55:35Z","timestamp":1762005335314,"version":"3.40.5"},"reference-count":17,"publisher":"Microbiology Society","issue":"9","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,23]]},"abstract":"Pancreatic necrosis infection (PNI) accounts for about 20\u201340\u200a% of severe acute pancreatitis. PNI caused by anaerobic bacteria is unusual but when they present, \n \n Clostridium perfringens<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> is the microorganism most commonly involved. We present a 60-year-old patient with a previous history of SARS-CoV-2, diagnosed with acute pancreatitis. During the hospitalisation he developed \n \n Clostridium perfringens<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> bacteraemia. A CT-scan showed pancreatic gas gangrene and a surgical necrosectomy was performed. \n \n Clostridium perfringens<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> was isolated in cultures of the pancreatic tissue and collections. The patient\u2019s clinical status improved after surgery and the appropriate medical therapy. He was discharged 76 days after admission. Nowadays, the \u2018step-up approach\u2019 is an accepted therapeutic tool in treatment of pancreatic necrosis and peripancreatic fluid collections. However, most authors suggest that Clostridum perfringens<\/jats:italic> infection requires a more aggressive approach due to the high mortality associated to clostridial infection.<\/jats:p>","DOI":"10.1099\/acmi.0.000261","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T16:40:35Z","timestamp":1631724035000},"source":"Crossref","is-referenced-by-count":9,"title":["Clostridium perfringens necrotizing pancreatitis: an unusual pathogen in pancreatic necrosis infection"],"prefix":"10.1099","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9182-3501","authenticated-orcid":false,"given":"Ana","family":"S\u00e1nchez-Gollarte","sequence":"first","affiliation":[{"name":"Department of General and Visceral Surgery, Hospital Universitario Pr\u00edncipe de Asturias, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0129-1159","authenticated-orcid":false,"given":"Laura","family":"Jim\u00e9nez-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, Hospital Universitario Pr\u00edncipe de Asturias, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"P\u00e9rez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, Hospital Universitario Pr\u00edncipe de Asturias, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9389-5805","authenticated-orcid":false,"given":"Cristina","family":"Vera-Mansilla","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, Hospital Universitario Pr\u00edncipe de Asturias, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alma","family":"Bl\u00e1zquez-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, Hospital Universitario Pr\u00edncipe de Asturias, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-0474","authenticated-orcid":false,"given":"Manuel","family":"D\u00edez-Alonso","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, Hospital Universitario Pr\u00edncipe de Asturias, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","first-page":"1","article-title":"2019 WSES guidelines for the management of severe acute pancreatitis","volume":"0","author":"Lepp\u00e4niemi","year":"2019","journal-title":"World J Emerg 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