{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T20:33:52Z","timestamp":1775680432593,"version":"3.50.1"},"reference-count":19,"publisher":"Microbiology Society","issue":"3","license":[{"start":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:00:00Z","timestamp":1649030400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,4]]},"abstract":"<jats:p>Hydrocephalus is a common condition worldwide, and is frequently managed by diversion of cerebrospinal fluid (CSF), either externally with a drain or internally with a shunt. An external ventricular drain (EVD) can be an essential treatment modality, but is associated with a risk of infection, most commonly caused by <jats:italic>Staphylococcal<\/jats:italic> species, which can result in meningitis or ventriculitis and a delay in the definitive management of the hydrocephalus. Here, we report the case of a patient who required an EVD to manage post-operative hydrocephalus following a craniotomy and microvascular decompression for trigeminal neuralgia. He subsequently developed EVD-associated infection with a vancomycin-resistant <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.5535\" xlink:type=\"simple\">Enterococcus faecium<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> (VRE), which was treated successfully with a 2-week course of intravenous linezolid monotherapy. The authors believe this to be the only described case of successful treatment within this time frame of a CSF VRE infection associated with indwelling foreign material.<\/jats:p>","DOI":"10.1099\/acmi.0.000335","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T16:18:06Z","timestamp":1648570686000},"source":"Crossref","is-referenced-by-count":5,"title":["Successful treatment of vancomycin-resistant enterococcal infection of an external ventricular drain with 2 weeks of intravenous linezolid"],"prefix":"10.1099","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1479-8979","authenticated-orcid":false,"given":"Michael D.","family":"Cearns","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Institute of Neurological Sciences, 1345 Govan Road, Glasgow G51 4TF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5381-0176","authenticated-orcid":false,"given":"Bruce T.","family":"McLintock","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Queen Elizabeth University Hospital, 1345 Govan Road, Glasgow G51 4TF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4784-7271","authenticated-orcid":false,"given":"Nigel","family":"Suttner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Institute of Neurological Sciences, 1345 Govan Road, Glasgow G51 4TF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3735-8615","authenticated-orcid":false,"given":"Kamaljit","family":"Khalsa","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Queen Elizabeth University Hospital, 1345 Govan Road, Glasgow G51 4TF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","DOI":"10.1055\/b-006-161147","volume-title":"Handbook of Neurosurgery","author":"Greenberg","year":"2020"},{"key":"R2","first-page":"42","article-title":"Hydrocephalus after posterior fossa operations","volume":"9","author":"Cabanes","year":"1978","journal-title":"Surg Neurol"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.3171\/2017.10.JNS17439"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1159\/000120968"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm501"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.12.071"},{"key":"R7","volume-title":"Infections of the Central Nervous System","author":"Scheld","year":"1997"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200207000-00024"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00226"},{"key":"R10","volume-title":"Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases","author":"Bennett","year":"2015"},{"key":"R11","first-page":"879","volume-title":"Oxford Handbook of Infectious Diseases and Microbiology","author":"To\u0308ro\u0308k","year":"2017"},{"key":"R12","article-title":"Laboratory surveillance of Enterococcus spp. bacteraemia in England, Wales and Northern Ireland: 2017","year":"2018"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199301073280104"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000090402.56130.82"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/708531"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1R412"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2000.0665"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.7205\/milmed.173.9.927"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw861"}],"container-title":["Access Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/acmi\/10.1099\/acmi.0.000335?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T22:25:03Z","timestamp":1702592703000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/acmi\/10.1099\/acmi.0.000335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,4]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,4,4]]}},"URL":"https:\/\/doi.org\/10.1099\/acmi.0.000335","relation":{},"ISSN":["2516-8290"],"issn-type":[{"value":"2516-8290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,4]]}}}