{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:50:05Z","timestamp":1787010605589,"version":"build-2736575974"},"reference-count":19,"publisher":"Microbiology Society","issue":"4","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,29]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction.<\/jats:bold>\n                    Cryptic aspergillosis, caused by cryptic species of\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    , is increasingly reported in humans and causes significant morbidity and mortality in immunocompromised individuals. The main aim of this study was to describe the occurrence of this entity at a large tertiary care centre and analyse the challenges in identifying them in a routine diagnostic laboratory.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods.<\/jats:bold>\n                    This was a retrospective case review of all patients diagnosed with cryptic\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    species from April 2019 to February 2020. The isolates were identified using conventional microbiological techniques, matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry (MALDI- TOF MS), 28S rRNA and internal transcribed spacer (ITS) sequencing.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results.<\/jats:bold>\n                    The species identified were\n                    <jats:italic>Aspergillus tamarii, Aspergillus lentulus<\/jats:italic>\n                    and\n                    <jats:italic>Aspergillus sydowii<\/jats:italic>\n                    . Identification by MALDI- TOF MS and sequencing was concordant for all except\n                    <jats:italic>A. sydowii<\/jats:italic>\n                    , with MALDI- TOF MS misidentifying it as\n                    <jats:italic>Aspergillus thermomutans<\/jats:italic>\n                    . All isolates showed low minimum inhibitory concentrations (MICs) for the panel of antifungal drugs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion.<\/jats:bold>\n                    Aspergillosis caused by cryptic\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    species presents a diagnostic challenge. This study confirms the importance of molecular methods for accurate identification.\n                  <\/jats:p>","DOI":"10.1099\/acmi.0.000344","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T13:18:04Z","timestamp":1649423884000},"source":"Crossref","is-referenced-by-count":11,"title":["Cryptic aspergillosis: a rare entity and a diagnostic challenge"],"prefix":"10.1099","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8417-4208","authenticated-orcid":false,"given":"Lavanya","family":"R.","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1652-5445","authenticated-orcid":false,"given":"Marilyn M.","family":"Ninan","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1857-6019","authenticated-orcid":false,"given":"Regi","family":"Kurien","sequence":"additional","affiliation":[{"name":"Department of ENT 3 and Anterior Skull Base Surgery, Christian Medical College, Vellore 632004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4133-1001","authenticated-orcid":false,"given":"Fouzia","family":"N. 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