{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:32:30Z","timestamp":1768807950028,"version":"3.49.0"},"reference-count":10,"publisher":"Microbiology Society","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"There are limited reports of patients with prosthetic valve infective endocarditis (IE) or recurrent IE due to highly beta-lactam-resistant viridans group streptococci. We present a case in which a patient with native valve IE due to beta-lactam-susceptible \n \n Streptococcus oralis<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> developed prosthetic valve IE due to highly beta-lactam-resistant \n \n S. oralis<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>. A 79-year-old man with a history of native aortic valve IE caused by beta-lactam-susceptible \n \n S. oralis<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> 21\u2009months prior to admission and aortic valve replacement was admitted to our hospital with a 2-week history of general malaise and low-grade fever. Transesophageal echocardiography showed a 20\u2009mm vegetation on the prosthetic aortic valve, and emergency cardiovascular surgery was performed on admission day 2. Three sets of blood cultures on admission were positive for highly beta-lactam-resistant \n \n S. oralis<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>. Vancomycin and cefazolin were administered as initial treatment. After the surgery, the patient was given vancomycin and gentamicin for 2\u2009weeks, followed by vancomycin for 4\u2009weeks. He was relapse-free at the 6-month follow-up. For patients with native valve IE due to \n \n S. oralis<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> who have undergone valve replacement more than 1\u2009year earlier, given the possibility of methicillin-resistant \n \n Staphylococcus aureus<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> as well as \n \n S. oralis<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> resistance to beta-lactams, it may be advisable to start vancomycin as an initial treatment and continue it until the infecting micro-organism has been proven to be susceptible to beta-lactams.<\/jats:p>","DOI":"10.1099\/acmi.0.000437","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T15:18:52Z","timestamp":1667488732000},"source":"Crossref","is-referenced-by-count":3,"title":["Prosthetic valve endocarditis due to highly beta-lactam-resistant Streptococcus oralis: a case report"],"prefix":"10.1099","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7867-9381","authenticated-orcid":false,"given":"Ippei","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan"},{"name":"Department of Pharmacy, Japanese Red Cross Musashino Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2042-0195","authenticated-orcid":false,"given":"Shinichiro","family":"Morioka","sequence":"additional","affiliation":[{"name":"Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arisa","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Japanese Red Cross Musashino Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Japanese Red Cross Musashino Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeaki","family":"Wajima","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Pharmacy, Meijo University, Nagoya, Japan"},{"name":"Department of Clinical Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemasa","family":"Nakaminami","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Infection Control, Japanese Red Cross Musashino Hospital, Tokyo, Japan"},{"name":"Department of Pharmacy, Japanese Red Cross Musashino Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/41.6.621"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000296"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-12-1101"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu260"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.17.2195"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-012-0465-9"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00516-19"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv319"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.11.4463-4465.2004"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2008.603"}],"container-title":["Access Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/acmi\/10.1099\/acmi.0.000437?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T18:26:17Z","timestamp":1702578377000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/acmi\/10.1099\/acmi.0.000437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,1]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11,1]]}},"URL":"https:\/\/doi.org\/10.1099\/acmi.0.000437","relation":{},"ISSN":["2516-8290"],"issn-type":[{"value":"2516-8290","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,1]]}}}