{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T04:21:24Z","timestamp":1793938884585,"version":"4.8.0"},"reference-count":26,"publisher":"Microbiology Society","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"\n Introduction.<\/jats:bold>\n Carbapenems are usually used in the treatment of infections caused by cephalosporin-resistant\n \n \n Enterobacterales<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n ; however, the increase in carbapenem-resistant\n \n \n Enterobacterales<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n (CRE) has become one of the most important problems in public health.\n \n \n Hafnia alvei<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n is associated with intestinal and extraintestinal infections, especially in patients with any chronic disease or some type of immunosupression.\n \n \n H. alvei<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n is resistant to first-generation aminopenicillins and cephalosporins owing to the \u03b2-lactamase (Amp C) in their chromosome; the only carbapenem-resistant\n \n \n Hafnia<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n strain described until now was due to a lack of the OmpK36 protein that plays an important role in permeability to carbapenems.\n <\/jats:p>\n \n Case presentation.<\/jats:bold>\n We present the case of a 65-year-old male diagnosed with acute lithiasic cholecystitis. Culture of the biliary prosthesis yielded a OXA-48-producing\n \n \n H. alvei<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n that was identified by MALDI-TOF (matrix-assisted laser desorption\/ionization-time of flight) MS. Carbapenemase production was detected by immunochromatography and confirmed by sequencing.\n <\/jats:p>\n \n Conclusion.<\/jats:bold>\n To our knowledge, this is the first report of OXA-48-producing\n \n \n H. alvei<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n probably obtained by horizontal transfer from\n \n \n Enterobacter cloacae<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n OXA-48 isolated in previous samples.\n <\/jats:p>","DOI":"10.1099\/acmi.0.000498.v3","type":"journal-article","created":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T12:19:11Z","timestamp":1687436351000},"source":"Crossref","is-referenced-by-count":4,"title":["First report of a carbapenemase OXA-48-producing Hafnia alvei clinical isolate"],"prefix":"10.1099","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8416-0786","authenticated-orcid":false,"given":"Laura","family":"Sevillano","sequence":"first","affiliation":[{"name":"Servicio de Microbiolog\u00eda, 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