{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:34:38Z","timestamp":1775079278406,"version":"3.50.1"},"reference-count":24,"publisher":"Microbiology Society","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:p>\n                    <jats:italic>Serratia marcescens (S. marcescens)<\/jats:italic>\n                    is a Gram-negative rod-shaped bacterium belonging to the\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    family, commonly found in various environments. This opportunistic pathogen can cause urinary tract infections, respiratory infections and septicaemia, but endocarditis is particularly rare and concerning due to its rapid and devastating progression. We report the first documented case worldwide of infective endocarditis (IE) caused by\n                    <jats:italic>S. marcescens<\/jats:italic>\n                    producing NDM-type carbapenemase, and the second reported case of\n                    <jats:italic>S. marcescens<\/jats:italic>\n                    endocarditis in a preterm infant. The patient was a preterm male infant born at 34\u2009weeks of gestation, from a triplet pregnancy, admitted to the neonatal intensive care unit on day 2 of life for respiratory distress. The mother, aged 39, had undiagnosed gestational diabetes. Premature rupture of membranes had occurred 10\u2009days before delivery, necessitating prophylactic treatment with amoxicillin. On day 4 of life, the newborn developed a fever with elevated C-reactive protein (CRP) levels and leucocytosis, leading to antibiotic therapy with colistin, imipenem and amikacin. Blood cultures revealed the presence of carbapenemase-producing\n                    <jats:italic>S. marcescens<\/jats:italic>\n                    sensitive to fluoroquinolones. A cardiac ultrasound showed a vegetation on the mitral valve, confirming the diagnosis of IE. Despite intensive treatment, the newborn died on day 16 of life due to septic shock. This rare case of endocarditis caused by\n                    <jats:italic>S. marcescens<\/jats:italic>\n                    highlights the severity of this infection in preterm infants. Treatment relies on appropriate antibiotic therapy. Prevention requires strict hygiene measures. Further research is needed to establish optimal therapeutic recommendations.\n                  <\/jats:p>","DOI":"10.1099\/acmi.0.000933.v3","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T13:16:26Z","timestamp":1747401386000},"source":"Crossref","is-referenced-by-count":1,"title":["First case of infective endocarditis due to NDM-type carbapenemase-producing Serratia marcescens in a preterm infant: a case report"],"prefix":"10.1099","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6416-7144","authenticated-orcid":false,"given":"Zakaria","family":"Malihy","sequence":"first","affiliation":[{"name":"Department of Bacteriology, Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy (University Mohammed V), Rabat, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikram","family":"El Abdallaoui","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital of Children, University Hospital of Rabat, Rabat, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tilila","family":"Abassor","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy (University Mohammed V), Rabat, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salah","family":"Sghir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Mohamed V Military Hospital of Rabat, Rabat, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yassine","family":"Ben Lahlou","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy (University Mohammed V), Rabat, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachid","family":"Abilkassem","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Mohamed V Military Hospital of Rabat, Rabat, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elmostafa","family":"Benaissa","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy (University Mohammed V), Rabat, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariama","family":"Chadli","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy (University Mohammed V), Rabat, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2022.08.443"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00859-07"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad193"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad271"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2021.05.003"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16040610"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/3281910"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v14.i9.1393"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17602"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.09.005"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.05.002"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.17346"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1177\/000992289803701205"},{"key":"R14","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1001\/jama.1981.03320090045029","article-title":"Serratia endocarditis in a pediatric burn patient. 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