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The pathogens that cause TB belong to the\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    complex (MTBC), with\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    and\n                    <jats:italic>Mycobacterium bovis<\/jats:italic>\n                    as the main representatives of human- and animal-adapted strains, respectively. One key genetic regulator of the MTBC members is the PhoPR system, which controls many processes, including the stress response, lipid metabolism and pathogenesis, among others. Previous studies identified a key G71I substitution in the\n                    <jats:italic>M. bovis<\/jats:italic>\n                    PhoR orthologue relative to\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    PhoR and suggested that PhoPR might be non-functional in animal-adapted strains, but recent work has highlighted the functionality of PhoPR in\n                    <jats:italic>M. bovis<\/jats:italic>\n                    despite the G71I substitution. Here, we compare the transcriptional effects of the PhoPR system of\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    H37Rv and\n                    <jats:italic>M. bovis<\/jats:italic>\n                    AF2122\/97 on an\n                    <jats:italic>M. bovis<\/jats:italic>\n                    AF2122\/97 \u0394\n                    <jats:italic>phoPR<\/jats:italic>\n                    knockout background. Our results show common patterns of gene expression between the two orthologues, but also clear differences in the expression of rubredoxin genes and lipid biosynthetic loci. This work adds to the evidence that the PhoPR system is indeed functional in\n                    <jats:italic>M. bovis<\/jats:italic>\n                    and suggests that PhoPR controls differential transcriptional programmes that are important in the adaptation to human or animal hosts.\n                  <\/jats:p>","DOI":"10.1099\/acmi.0.001087.v3","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T16:17:36Z","timestamp":1769617056000},"source":"Crossref","is-referenced-by-count":0,"title":["Different transcriptional regulatory activities of Mycobacterium bovis and Mycobacterium tuberculosis PhoPR systems"],"prefix":"10.1099","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8521-7780","authenticated-orcid":false,"given":"Jose Maria","family":"Urtasun-Elizari","sequence":"first","affiliation":[{"name":"UCD School of Veterinary Medicine, University College Dublin, Belfield, Dublin, D04 V1W8, Ireland"},{"name":"Present address: Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1111, 1081 HV, Amsterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruoyao","family":"Ma","sequence":"additional","affiliation":[{"name":"Present address: Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, 10065, USA"},{"name":"UCD School of Veterinary Medicine, University College Dublin, Belfield, Dublin, D04 V1W8, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayleah","family":"Pickford","sequence":"additional","affiliation":[{"name":"School of Biosciences and Institute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Farrell","sequence":"additional","affiliation":[{"name":"UCD School of Veterinary Medicine, University College Dublin, Belfield, Dublin, D04 V1W8, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor","family":"Perets","sequence":"additional","affiliation":[{"name":"UCD School of Veterinary Medicine, University College Dublin, Belfield, Dublin, D04 V1W8, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus","family":"Urtasun-Elizari","sequence":"additional","affiliation":[{"name":"MRC LMS, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Institute for Vaccine Research and Development, Hokkaido University, Kita 21, Nishi 11, Kita-ku, Sapporo, 001-0021, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Nakajima","sequence":"additional","affiliation":[{"name":"International Institute for Zoonosis Control, Hokkaido University, Kita 20, Nishi 10, Kita-ku, Sapporo, 001-0020, Japan"},{"name":"Institute for Vaccine Research and Development, Hokkaido University, Kita 21, Nishi 11, Kita-ku, Sapporo, 001-0021, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"International Institute for Zoonosis Control, Hokkaido University, Kita 20, Nishi 10, Kita-ku, Sapporo, 001-0020, Japan"},{"name":"Institute for Vaccine Research and Development, Hokkaido University, Kita 21, Nishi 11, Kita-ku, Sapporo, 001-0021, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apoorva","family":"Bhatt","sequence":"additional","affiliation":[{"name":"School of Biosciences and Institute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"MacHugh","sequence":"additional","affiliation":[{"name":"UCD One Health Centre, University College Dublin, Belfield, 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