{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:47:16Z","timestamp":1782827236450,"version":"3.54.5"},"reference-count":48,"publisher":"Microbiology Society","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bupa Foundation","award":["TBF-M11-019"],"award-info":[{"award-number":["TBF-M11-019"]}]},{"name":"NIHR Research Capability Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:p>\n                    <jats:italic>Moraxella catarrhalis<\/jats:italic>\n                    is an increasingly important pathogen, recognized as a common cause of respiratory tract infections. It is particularly known for its role in causing otitis media in children and exacerbations of chronic obstructive pulmonary disease (COPD) in adults. With growing interest in developing vaccines against\n                    <jats:italic>M. catarrhalis<\/jats:italic>\n                    , a deeper understanding of epidemiology in both carriage and disease is crucial. Here, we present an all-age, community-based, upper respiratory tract carriage study (the Solent SMART Study) designed to investigate the epidemiology of, and risk factors for,\n                    <jats:italic>M. catarrhalis<\/jats:italic>\n                    carriage. In total,\n                    <jats:italic>n<\/jats:italic>\n                    =1,622 community-based participants were recruited with an additional\n                    <jats:italic>n<\/jats:italic>\n                    =79 individuals recruited from care\/nursing homes in the Southampton\/Hampshire UK region from whom a total of\n                    <jats:italic>n<\/jats:italic>\n                    =228\n                    <jats:italic>M<\/jats:italic>\n                    .\n                    <jats:italic>catarrhalis<\/jats:italic>\n                    were isolated. Carriage prevalence was 8% (95% CI: 6.7\u20139.4%) in community-based participants, 19% (95% CI: 11.0\u201329.4%) in care\/nursing home residents and 4.7% (95% CI: 1.6\u201310.7%) in the community-based subset with COPD (\n                    <jats:italic>n<\/jats:italic>\n                    =106). Nasopharyngeal carriage site, young age, microbial co-carriage with\n                    <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                    ,\n                    <jats:italic>Haemophilus influenzae<\/jats:italic>\n                    and\n                    <jats:italic>Neisseria meningitidis<\/jats:italic>\n                    and recent\/concurrent respiratory tract infection were all positively associated with the carriage of\n                    <jats:italic>M. catarrhalis<\/jats:italic>\n                    . Antimicrobial resistance testing showed that\n                    <jats:italic>n<\/jats:italic>\n                    =91 (41.4%) of the 220 isolates tested resistant to at least 1 antibiotic, with the most frequent being resistance to chloramphenicol (\n                    <jats:italic>n<\/jats:italic>\n                    =76, 34.5%) and ciprofloxacin (\n                    <jats:italic>n<\/jats:italic>\n                    =64, 29.1%).\n                  <\/jats:p>","DOI":"10.1099\/acmi.0.001117.v3","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:17:24Z","timestamp":1782825444000},"source":"Crossref","is-referenced-by-count":0,"title":["Carriage epidemiology of Moraxella catarrhalis in an all-age community cohort between 2016 and 2018"],"prefix":"10.1099","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8920-0812","authenticated-orcid":false,"given":"Denise E.","family":"Morris","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1146-9093","authenticated-orcid":false,"given":"Alex J. 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