{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:47:47Z","timestamp":1791838067631,"version":"4.3.4"},"reference-count":19,"publisher":"Microbiology Society","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction.<\/jats:bold>\n                    Despite the established pathogenicity of\n                    <jats:italic>Aggregatibacter aphrophilus<\/jats:italic>\n                    , few clinical cases have been described in published literature.\n                    <jats:italic>A. aphrophilus<\/jats:italic>\n                    is a rare cause of prosthetic valve endocarditis and diagnosis is challenging based on nonspecific symptoms on presentation. High clinical suspicion for infective endocarditis is warranted in patients with cardiac prosthetic material and positive blood cultures. Poor dentition and dental procedures, along with other risk factors, are associated with\n                    <jats:italic>A. aphrophilus<\/jats:italic>\n                    bacteraemia. We describe a case of\n                    <jats:italic>A. aphrophilus<\/jats:italic>\n                    bacteraemia in which the diagnosis of infective endocarditis was complicated by equivocal echocardiographic findings and an initially challenging Gram stain interpretation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Case Presentation.<\/jats:bold>\n                    A 59-year-old male patient with a history of bioprosthetic aortic valve replacement, atrial septal defect repair and remote dental cleaning presented to the emergency department with persistent high fevers, headaches and lethargy. Initial blood cultures were drawn and were positive for \u2018Gram-positive organisms\u2019, but specific morphology was challenging to determine. Subsequent testing, including MALDI-TOF, confirmed the growth of\n                    <jats:italic>A. aphrophilus<\/jats:italic>\n                    .\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion.<\/jats:bold>\n                    Rapid identification of\n                    <jats:italic>A. aphrophilus<\/jats:italic>\n                    and recognition of the potential for infective endocarditis are paramount to ensuring adequate treatment initiation and success. This case highlights the diagnostic difficulty associated with initial Gram stain interpretation of this fastidious organism.\n                  <\/jats:p>","DOI":"10.1099\/acmi.0.001248.v3","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:16:43Z","timestamp":1791836203000},"source":"Crossref","is-referenced-by-count":0,"title":["Aggregatibacter aphrophilus bacteraemia with suspected infective endocarditis in a patient with bioprosthetic aortic valve replacement and atrial septal defect repair"],"prefix":"10.1099","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3301-4951","authenticated-orcid":false,"given":"Danielle G.","family":"Co","sequence":"first","affiliation":[{"name":"Lower Mainland Pharmacy Services, Burnaby Hospital, Fraser Health, Burnaby, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanisha","family":"Misra","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Lin","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada"},{"name":"Lower Mainland Pharmacy Services, Burnaby Hospital, Fraser Health, Burnaby, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1726-753X","authenticated-orcid":false,"given":"Merisa","family":"Mok","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada"},{"name":"Lower Mainland Pharmacy Services, Burnaby Hospital, Fraser Health, Burnaby, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Mina","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada"},{"name":"Division of Medical Microbiology, Surrey Memorial Hospital, Fraser Health, Surrey, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Kadhim","sequence":"additional","affiliation":[{"name":"Division of Medical Microbiology, Surrey Memorial Hospital, Fraser Health, Surrey, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7015-1560","authenticated-orcid":false,"given":"Jennifer A.","family":"Losie","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of British Columbia, Vancouver, BC, Canada"},{"name":"Division of Infectious Diseases, Department of Medicine, Fraser Health, Burnaby, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001612"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2020.e00753"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000296"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.47487\/apcyccv.v4i3.306"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-022-01932-5"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2016.1164032"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063181"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-021-04240-3"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad193"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.64412"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2022.107337"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1093\/omcr\/omab043"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.23107"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-025-10913-7"},{"key":"R15","article-title":"Aggregatibacter - 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