{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:33:55Z","timestamp":1789194835285,"version":"build-2803163510"},"reference-count":47,"publisher":"Microbiology Society","issue":"Pt_7","funder":[{"DOI":"10.13039\/100008392","name":"Danish Medical Research Council","doi-asserted-by":"crossref","award":["271-08-0808"],"award-info":[{"award-number":["271-08-0808"]}],"id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012526","name":"Faculty of Health Sciences, Aarhus University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012526","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7,1]]},"abstract":"\n The Anginosus group of the genus\n \n \n Streptococcus<\/jats:italic>\n <\/jats:ext-link>\n <\/jats:named-content>\n has been the subject of much taxonomic confusion, which has hampered the full appreciation of its clinical significance. The purpose of this study was to critically re-examine the taxonomy of the Anginosus group, with special attention to \u03b2-haemolytic, Lancefield group C strains, using multilocus sequence analysis (MLSA) combined with 16S rRNA gene sequence and phenotypic analyses. Phylogenetic analysis of concatenated sequences of seven housekeeping genes previously used for examination of viridans streptococci distinguished seven distinct and coherent clusters in the Anginosus group. Analyses of 16S rRNA gene sequences and phenotypic characters supported the MLSA clustering and currently recognized taxa of the Anginosus group. Single gene analyses showed considerable allele sharing between species, thereby invalidating identification based on single-locus sequencing. Two novel clusters of \u03b2-haemolytic, Lancefield group C strains within the\n \n \n Streptococcus constellatus<\/jats:italic>\n <\/jats:ext-link>\n <\/jats:named-content>\n and\n \n \n Streptococcus anginosus<\/jats:italic>\n <\/jats:ext-link>\n <\/jats:named-content>\n species and isolated from patients with sore throat showed sufficient phylogenetic distances from other clusters to warrant status as novel subspecies. The novel cluster within\n \n \n S. anginosus<\/jats:italic>\n <\/jats:ext-link>\n <\/jats:named-content>\n was identified as the previously recognized DNA homology cluster, DNA group 2. The names\n S. anginosus<\/jats:italic>\n subsp.\n whileyi<\/jats:italic>\n subsp. nov. (type strain CCUG 39159\n T<\/jats:sup>\n \u200a=\u200aDSM 25818\n T<\/jats:sup>\n \u200a=\u200aSK1267\n T<\/jats:sup>\n ) and\n S. constellatus<\/jats:italic>\n subsp.\n viborgensis<\/jats:italic>\n subsp. nov. (type strain SK1359\n T<\/jats:sup>\n \u200a=\u200aCCUG 62387\n T<\/jats:sup>\n \u200a=\u200aDSM 25819\n T<\/jats:sup>\n ) are proposed.\n <\/jats:p>","DOI":"10.1099\/ijs.0.043232-0","type":"journal-article","created":{"date-parts":[[2012,12,8]],"date-time":"2012-12-08T03:15:51Z","timestamp":1354936551000},"page":"2506-2519","source":"Crossref","is-referenced-by-count":80,"title":["Taxonomy of the Anginosus group of the genus \n \n Streptococcus\n \n and description of Streptococcus anginosus subsp. whileyi subsp. nov. and Streptococcus constellatus subsp. viborgensis subsp. nov."],"prefix":"10.1099","volume":"63","author":[{"given":"Anders","family":"Jensen","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mogens","family":"Kilian","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"r1","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1128\/JCM.33.6.1592-1595.1995","article-title":"Species identification of members of the Streptococcus milleri group isolated from the vagina by ID 32 Strep system and differential phenotypic characteristics","volume":"33","author":"Ahmet","year":"1995","journal-title":"J Clin Microbiol"},{"key":"r2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1099\/00207713-41-4-487","article-title":"Intrageneric structure of Streptococcus based on comparative analysis of small-subunit rRNA 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