{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:44:32Z","timestamp":1793018672678,"version":"4.5.0"},"reference-count":34,"publisher":"Microbiology Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"\n We herein describe the first novel species within the genus\n \n \n Eikenella<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n since it was established in 1972 by the reclassification of\n \u2018Bacteroides corrodens<\/jats:italic>\n \u2019 to\n \n \n Eikenella corrodens<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n . From a polymicrobial brain abscess, we encountered an\n \n \n Eikenella<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n isolate, PXX\n T<\/jats:sup>\n , that could not validly be named\n \n \n E. corrodens<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n . The isolate grew on blood agar with small, translucent, pitting colonies after 3\u2009days of anaerobic incubation. By reviewing previously collected invasive isolates, we found an additional\n \n \n Eikenella<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n strain, EI-02, from a blood culture exhibiting the same properties as PXX\n T<\/jats:sup>\n . Phylogenetic analyses based on both whole genome and individual house-keeping genes confirmed that the two strains allocate in a phylogenetic cluster separate from\n \n \n E. corrodens<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n . Using specific amplification and sequencing of the\n Eikenella nusG<\/jats:italic>\n gene, we further detected the novel\n \n \n Eikenella<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n species in six historic brain abscesses previously reported to contain\n \n \n E. corrodens<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n based on 16S metagenomics. Out of 24\n \n \n Eikenella<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n whole-genome projects available in GenBank, eight cluster together with PXX\n T<\/jats:sup>\n and EI-02. These isolates were recovered from brain abscess (\n n<\/jats:italic>\n =2), blood (\n n<\/jats:italic>\n =1), bone\/soft tissue (\n n<\/jats:italic>\n =3), parotid gland (\n n<\/jats:italic>\n =1) and unknown (\n n<\/jats:italic>\n =1). It remains to be investigated whether the new species can cause endocarditis. The average nucleotide identity value between strain PXX\n T<\/jats:sup>\n and the\n \n \n E. corrodens<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\n type strain ATCC 23834\n T<\/jats:sup>\n was 92.1\u200a% and the corresponding genome-to-genome distance value was 47.1\u200a%, both supporting the classification of PXX\n T<\/jats:sup>\n as a novel species. For this species we propose the name\n Eikenella exigua<\/jats:italic>\n . The type strain of\n E. exigua<\/jats:italic>\n is PXX\n T<\/jats:sup>\n (DSM 109756\n T<\/jats:sup>\n , NCTC 14318\n T<\/jats:sup>\n ).\n <\/jats:p>","DOI":"10.1099\/ijsem.0.003827","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T13:12:27Z","timestamp":1573045947000},"page":"1478-1488","source":"Crossref","is-referenced-by-count":21,"title":["Eikenella exigua sp. nov., isolated from brain abscess and blood"],"prefix":"10.1099","volume":"70","author":[{"given":"Kristin A.","family":"Stormo","sequence":"first","affiliation":[{"name":"Department of Microbiology, Haukeland University Hospital, Bergen, Norway"},{"name":"Section of Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randi M.","family":"Nygaard","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbj\u00f8rn S.","family":"Bruvold","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grete","family":"Dimmen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7457-5902","authenticated-orcid":false,"given":"Paul Christoffer","family":"Lindemann","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stina","family":"Jordal","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4390-0370","authenticated-orcid":false,"given":"\u00d8yvind","family":"Kommedal","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","first-page":"1","volume-title":"Manual of Clinical Microbiology","author":"Zbinden","year":"2015"},{"key":"R2","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1699-0463.1958.tb04677.x","article-title":"Studies on an anaerobic, rodshaped, gram-negative microorganism: Bacteroides corrodens n. sp","volume":"43","author":"Eiken","year":"1958","journal-title":"Acta Pathol Microbiol Scand"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-22-2-73"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.06.015"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1007\/PL00011259"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.24.2.117"},{"key":"R7","first-page":"224","article-title":"Eikenella corrodens: an unusual cause of severe parapneumonic infection and empyema in immunocompetent patients","volume":"93","author":"Hoyler","year":"2001","journal-title":"J Natl Med Assoc"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777X.83546"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1086\/320883"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1056\/ENEJMicm010433"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-2949-4"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.10.053"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/686812"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1016\/0363-5023(93)90056-9"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2006.03.021"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2016.08.011"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-3019(96)00192-9"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1007\/s002470050600"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.1.177-207.2001"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.65440-0"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01228-07"},{"key":"R22","volume-title":"Interpretive Criteria for Identification of Bacteria an Fungi by DNA Target Sequencing; 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