{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:14:43Z","timestamp":1792512883497,"version":"4.5.0"},"reference-count":55,"publisher":"Microbiology Society","issue":"5","funder":[{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 82030116"],"award-info":[{"award-number":["No. 82030116"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,13]]},"abstract":"<jats:p>An oval to rod-shaped, Gram-stain-positive, strictly anaerobic bacterium, designated LFL-14<jats:sup>T<\/jats:sup>, was isolated from the faeces of a healthy Chinese woman. Cells of the strain were non-spore-forming, grew optimally at 37\u200a\u00b0C (growth range 30\u201345\u200a\u00b0C) and pH 7.0 (growth range 6.0\u20139.0) under anaerobic conditions in the liquid modified Gifu anaerobic medium (mGAM). The result of 16S rRNA gene-based analysis indicated that LFL-14<jats:sup>T<\/jats:sup> shared an identity of 94.7\u200a0% with <jats:italic>Eubacterium ventriosum<\/jats:italic> ATCC 27560<jats:sup>T<\/jats:sup>, indicating LFL-14<jats:sup>T<\/jats:sup> represented a novel taxon. The results of genome-based analysis revealed that the average nucleotide identity (ANI), the digital DNA\u2013DNA hybridisation (dDDH) and average amino acid identity (AAI) between LFL-14<jats:sup>T<\/jats:sup> and its phylogenetically closest neighbour, <jats:italic>Eubacterium ventriosum<\/jats:italic> ATCC 27560<jats:sup>T<\/jats:sup>, were 77.0\u200a%, 24.6 and 70.9\u200a%, respectively, indicating that LFL-14<jats:sup>T<\/jats:sup> represents a novel species of the genus <jats:italic>Eubacterium<\/jats:italic>. The genome size of LFL-14<jats:sup>T<\/jats:sup> was 2.92 Mbp and the DNA G+C content was 33.14\u2009mol%. We analysed the distribution of the genome of LFL-14<jats:sup>T<\/jats:sup> in cohorts of healthy individuals, type 2 diabetes patients (T2D) and patients with non-alcoholic fatty liver disease (NAFLD). We found that its abundance was higher in the T2D cohort, but it had a low average abundance of less than 0.2\u200a% in all three cohorts. The percentages of frequency of occurrence in the T2D, healthy and NAFLD cohorts were 48.87\u200a%, 16.72\u200a% and 13.10\u200a% respectively. The major cellular fatty acids of LFL-14<jats:sup>T<\/jats:sup> were C<jats:sub>16\u200a:\u200a0<\/jats:sub> (34.4\u200a%), C<jats:sub>17\u200a:\u200a0<\/jats:sub> 2-OH (21.4\u200a%) and C<jats:sub>14\u200a:\u200a0<\/jats:sub> (11.7\u200a%). Additionally, the strain contained diphosphatidylglycerol (DPG) and phosphatidylethanolamine (PE), as well as unidentified phospholipids and unidentified glycolipids. The glucose fermentation products of LFL-14<jats:sup>T<\/jats:sup> were acetate and butyrate. In summary, On the basis of its chemotaxonomic, phenotypic, phylogenetic and phylogenomic properties, strain LFL-14<jats:sup>T<\/jats:sup> (= CGMCC 1.18005<jats:sup>T<\/jats:sup> = KCTC 25580<jats:sup>T<\/jats:sup>) is identified as representing a novel species of the genus <jats:italic>Eubacterium<\/jats:italic>, for which the name <jats:italic>Eubacterium album<\/jats:italic> sp. nov. is proposed.<\/jats:p>","DOI":"10.1099\/ijsem.0.006380","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T18:16:04Z","timestamp":1715624164000},"source":"Crossref","is-referenced-by-count":7,"title":["Eubacterium album sp. nov., a butyrate-producing bacterium isolated from faeces of a healthy human"],"prefix":"10.1099","volume":"74","author":[{"given":"Feng-Lan","family":"Liu","sequence":"first","affiliation":[{"name":"College of Life Sciences, Hebei University, Baoding, 071000, PR 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