{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T11:36:12Z","timestamp":1770464172573,"version":"3.49.0"},"reference-count":28,"publisher":"Microbiology Society","issue":"2","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Western Australian Child Research Fund","award":["2023\/GR000633"],"award-info":[{"award-number":["2023\/GR000633"]}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["APP1174455"],"award-info":[{"award-number":["APP1174455"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"crossref","award":["OPP1017579"],"award-info":[{"award-number":["OPP1017579"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"crossref","award":["OPP1017641"],"award-info":[{"award-number":["OPP1017641"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"crossref","award":["1U01AI110466-01A1"],"award-info":[{"award-number":["1U01AI110466-01A1"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,6]]},"abstract":"\n Emerging evidence supports the role of the nasopharyngeal microbiome in respiratory health, including association with conditions such as asthma and respiratory tract infections. One dominant commensal genus is\n Corynebacterium<\/jats:italic>\n , members of which are commonly present in the nasopharynx of infants. These commensal\n Corynebacterium<\/jats:italic>\n spp. have been reported to correlate with respiratory health. In this paper, we present isolate MNWGS58\n T<\/jats:sup>\n isolated from the nasopharynx of a South African infant. Genomic analysis of the whole-genome sequence of MNWGS58\n T<\/jats:sup>\n revealed that it is phylogenetically closely related to other\n Corynebacterium<\/jats:italic>\n spp. found in the nasopharynx,\n Corynebacterium propinquum<\/jats:italic>\n [85% average nucleotide identity (ANI)] and\n Corynebacterium pseudodiphtheriticum<\/jats:italic>\n (84% ANI). Bacterial identification using matrix-assisted laser desorption\/ionization time-of-flight MS identified MNWGS58\n T<\/jats:sup>\n as\n C. pseudodiphtheriticum<\/jats:italic>\n . The API Coryne assay identified the novel isolate as\n C. propinquum<\/jats:italic>\n , and the VITEK 2 ANC assay identified the novel isolate as\n Corynebacterium otitidis<\/jats:italic>\n . Both genomic analyses and phenotypic analyses show striking similarities to\n C. propinquum<\/jats:italic>\n and\n C. pseudodiphtheriticum<\/jats:italic>\n . The cell wall is consistent with closely related\n Corynebacterium<\/jats:italic>\n spp., albeit with a higher C\n 17:0<\/jats:sub>\n content. The genome is 2.48Mbp with a G+C content of 56.9 mol%. Digital DNA\u2013DNA hybridization values for MNWGS58\n T<\/jats:sup>\n were low when compared to\n C. pseudodiphtheriticum<\/jats:italic>\n MNWGS56 and\n C. propinquum<\/jats:italic>\n MNWGS51 (27.4 and 28.4%, respectively). Although there are phenotypic similarities, 85% ANI with the closest\n Corynebacterium<\/jats:italic>\n spp. strongly supports the classification of a novel species of\n Corynebacterium<\/jats:italic>\n , for which we propose the name\n Corynebacterium drakensteinense<\/jats:italic>\n sp. nov., with the type strain MNWGS58\n T<\/jats:sup>\n (=TSD-445\n T<\/jats:sup>\n =NCTC 15058\n T<\/jats:sup>\n ). It will be important to elucidate the role of this novel species of\n Corynebacterium<\/jats:italic>\n in the human nasopharynx and identify additional niches for this species in future studies.\n <\/jats:p>","DOI":"10.1099\/ijsem.0.007068","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T17:16:03Z","timestamp":1770398163000},"source":"Crossref","is-referenced-by-count":0,"title":["Corynebacterium drakensteinense sp. nov., isolated from the nasopharynx of a healthy South African infant"],"prefix":"10.1099","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0264-0215","authenticated-orcid":false,"given":"Robbie R.","family":"Haines","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences, The University of Western Australia, Nedlands, WA, Australia"},{"name":"The Marshall Centre for Infectious Diseases Research and Training, The University of Western Australia, Nedlands, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Basuki","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, The University of Western Australia, Nedlands, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa P.","family":"Tenaglia","sequence":"additional","affiliation":[{"name":"Wesfarmers Centre for Vaccines and Infectious Diseases, The Kids Institute, Nedlands, WA, Australia"},{"name":"School of Biomedical Sciences, The University of Western Australia, Nedlands, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather J.","family":"Zar","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark P.","family":"Nicol","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa"},{"name":"School of Biomedical Sciences, The University of Western Australia, Nedlands, WA, Australia"},{"name":"The Marshall Centre for Infectious Diseases Research and Training, The University of Western Australia, Nedlands, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritika","family":"Kar Bahal","sequence":"additional","affiliation":[{"name":"The Marshall Centre for Infectious Diseases Research and Training, The University of Western Australia, Nedlands, WA, Australia"},{"name":"School of Biomedical Sciences, The University of Western Australia, Nedlands, WA, 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