{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:50:25Z","timestamp":1787010625624,"version":"build-2736575974"},"reference-count":32,"publisher":"Microbiology Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"DOI":"10.1099\/jgv.0.000316","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T06:12:17Z","timestamp":1445321537000},"page":"53-59","source":"Crossref","is-referenced-by-count":15,"title":["Amino acid residues Ala283 and His421 in the RNA-dependent RNA polymerase of porcine reproductive and respiratory syndrome virus play important roles in viral ribavirin sensitivity and quasispecies diversity"],"prefix":"10.1099","volume":"97","author":[{"given":"Debin","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Jin","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"jgv000316-Agudo","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001072"},{"key":"jgv000316-Beerens1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00564-07"},{"key":"jgv000316-Coffey1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111650108"},{"key":"jgv000316-Crotty1","doi-asserted-by":"publisher","DOI":"10.1038\/82191"},{"key":"jgv000316-Curti1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06968-11"},{"key":"jgv000316-Domingo1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.51.1.151"},{"key":"jgv000316-Fang1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2010.07.030"},{"key":"jgv000316-Gnadig1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1204022109"},{"key":"jgv000316-Hanada1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msi089"},{"key":"jgv000316-Holland1","first-page":"1","article-title":"RNA virus populations as quasispecies","volume":"176","author":"Holland","year":"1992","journal-title":"Curr Top Microbiol Immunol"},{"key":"jgv000316-Kim1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2012.10.018"},{"key":"jgv000316-Kimman1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.04.022"},{"key":"jgv000316-Koboldt1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.129684.111"},{"key":"jgv000316-Kong1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2011.05.009"},{"key":"jgv000316-Langmead1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"jgv000316-Li1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"jgv000316-Li12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004216"},{"key":"jgv000316-Lu1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2014.11.016"},{"key":"jgv000316-Martin-Valls1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02858-13"},{"key":"jgv000316-Murtaugh1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2010.08.015"},{"key":"jgv000316-Ni1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2011.06.027"},{"key":"jgv000316-Pfeiffer1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1232294100"},{"key":"jgv000316-Rozen-Gagnon1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003877"},{"key":"jgv000316-Sadeghipour1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02139-12"},{"key":"jgv000316-Sierra1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01606-06"},{"key":"jgv000316-Smith1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003565"},{"key":"jgv000316-Tian1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06836-11"},{"key":"jgv000316-Van1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005009"},{"key":"jgv000316-Vignuzzi1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04388"},{"key":"jgv000316-Vignuzzi12","doi-asserted-by":"publisher","DOI":"10.1038\/nm1726"},{"key":"jgv000316-Zeng1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03594-13"},{"key":"jgv000316-Zhou1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-011-4216-4"}],"container-title":["Journal of General Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jgv\/10.1099\/jgv.0.000316?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T11:10:52Z","timestamp":1576667452000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jgv\/10.1099\/jgv.0.000316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1,1]]}},"URL":"https:\/\/doi.org\/10.1099\/jgv.0.000316","relation":{},"ISSN":["0022-1317","1465-2099"],"issn-type":[{"value":"0022-1317","type":"print"},{"value":"1465-2099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,1]]}}}