{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:56:01Z","timestamp":1775195761137,"version":"3.50.1"},"reference-count":29,"publisher":"Microbiology Society","issue":"9","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:p>Antibodies play a pivotal role against viral infection, and maintenance of protection is dependent on plasma and memory B-cells. Understanding antigen-specific B-cell responses in cattle is essential to inform future vaccine design. We have previously defined T-cell-dependent and -independent B-cell responses in cattle, as a prelude to investigating foot-and-mouth-disease-virus (FMDV)-specific B-cell responses. In this study, we have used an FMDV O-serotype vaccination (O<jats:sub>1<\/jats:sub>-Manisa or O SKR) and live-virus challenge (FMDV O SKR) to investigate the homologous and heterologous B-cell response in cattle following both vaccination and live-virus challenge. The FMDV O-serotype vaccines were able to induce a cross-reactive plasma-cell response, specific for both O<jats:sub>1<\/jats:sub>-Manisa and O SKR, post-vaccination. Post-FMDV O SKR live-virus challenge, the heterologous O<jats:sub>1<\/jats:sub>-Manisa vaccination provided cross-protection against O SKR challenge and cross-reactive O SKR-specific plasma cells were induced. However, vaccination and live-virus challenge were not able to induce a detectable FMDV O-serotype-specific memory B-cell response in any of the cattle. The aim of new FMDV vaccines should be to induce memory responses and increased duration of immunity in cattle.<\/jats:p>","DOI":"10.1099\/jgv.0.000517","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T06:12:28Z","timestamp":1464934348000},"page":"2201-2209","source":"Crossref","is-referenced-by-count":11,"title":["The B-cell response to foot-and-mouth-disease virus in cattle following vaccination and live-virus challenge"],"prefix":"10.1099","volume":"97","author":[{"given":"Clare F. J.","family":"Grant","sequence":"first","affiliation":[{"name":"The Pirbright Institute, Ash Road, Woking, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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