{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:49:25Z","timestamp":1787010565402,"version":"build-2736575974"},"reference-count":26,"publisher":"Microbiology Society","issue":"6","funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"crossref","award":["64815"],"award-info":[{"award-number":["64815"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:p>Lumpy skin disease virus (LSDV), a Capripoxvirus, is of economic importance in the cattle industry and is controlled by vaccination. A comparison was made of the host response to the two LSDV vaccines Neethling and Herbivac LS, with reference to the well-studied Orthopoxvirus, modified vaccinia Ankara (MVA), in a mouse model. Because the vaccines differ at the superoxide dismutase homologue (SOD) gene locus, recombinant SOD knock-out and knock-in nLSDV vaccines were constructed and all four vaccines were tested for the induction and inhibition of apoptosis. The SOD homologue was associated both with induction of apoptosis as well as inhibition of camptothecin-induced apoptosis. Histological analysis of chorioallantoic membranes of fertilized hens\u2019 eggs infected with the four different vaccines indicated marked mesodermal proliferation associated with vaccines containing the full-length SOD homologue as well as increased immune cell infiltration. Our findings suggest that the SOD homologue may influence vaccine immunogenicity.<\/jats:p>","DOI":"10.1099\/jgv.0.001423","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T11:25:14Z","timestamp":1589196314000},"page":"645-650","source":"Crossref","is-referenced-by-count":14,"title":["Influence of the lumpy skin disease virus (LSDV) superoxide dismutase homologue on host transcriptional activity, apoptosis and histopathology"],"prefix":"10.1099","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1258-6374","authenticated-orcid":false,"given":"Henry","family":"Munyanduki","sequence":"first","affiliation":[{"name":"Present address: The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey, UK"},{"name":"Division of Medical Virology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7925, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8929-6279","authenticated-orcid":false,"given":"Nicola","family":"Douglass","sequence":"additional","affiliation":[{"name":"Division of Medical Virology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7925, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2092-4855","authenticated-orcid":false,"given":"Kristy","family":"Offerman","sequence":"additional","affiliation":[{"name":"Present address: Plant Health Products (Pty) Ltd, Nottingham Road, South Africa"},{"name":"Division of Medical Virology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7925, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0183-2007","authenticated-orcid":false,"given":"Olivia","family":"Carulei","sequence":"additional","affiliation":[{"name":"Division of Medical Virology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7925, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5467-1200","authenticated-orcid":false,"given":"Anna-Lise","family":"Williamson","sequence":"additional","affiliation":[{"name":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Anzio Road, Observatory, 7925, Cape Town, South Africa"},{"name":"Division of Medical Virology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7925, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","article-title":"Manual of diagnostic tests and vaccines for terrestrial animals 2017","year":"2017","journal-title":"OIE Terrestial Manual"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.i2800"},{"key":"R3","article-title":"LUMPY skin disease: current situation in Europe and neighbouring regions and necessary control measures to halt the spread in south-east Europe","author":"T","year":"2016","journal-title":"OIE Regional Commission"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.12444"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-019-04405-8"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-003-0102-0"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.15.7018-7029.2001"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.19.10265-10275.2004"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2002.1383"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02031-14"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02588-14"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300644200"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.9.5799-5811.2005"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.6274"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2017.02.017"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-1659-1"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.11.6493-6506.2003"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.11.5820-5834.2004"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2010.00902.x"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.24.13978"},{"key":"R21","doi-asserted-by":"crossref","DOI":"10.1007\/0-387-36005-0_10","article-title":"Parp and the release of apoptosis-inducing factor from mitochondria","author":"Hong","year":"2006","journal-title":"Poly (ADP-Ribosyl) ation. Springer"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105296200"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp421"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.054049-0"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot4986"},{"key":"R26","first-page":"167","article-title":"A study of the pathology of lumpy skin disease in cattle","volume":"49","author":"Prozesky","year":"1982","journal-title":"Onderstepoort J Vet Res"}],"container-title":["Journal of General Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jgv\/10.1099\/jgv.0.001423?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T11:14:17Z","timestamp":1593774857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jgv\/10.1099\/jgv.0.001423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,1]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.1099\/jgv.0.001423","relation":{},"ISSN":["0022-1317","1465-2099"],"issn-type":[{"value":"0022-1317","type":"print"},{"value":"1465-2099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,1]]}}}