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Interferon regulatory factor 7 (IRF7) is the main transcriptional regulator of type I IFN, and it is crucial for the induction of IFN\u03b1\/\u03b2 and the type I IFN-dependent immune response. In this study, we focused on the role of IRF7 in the pathogenicity and immunogenicity of RABV using an IRF7<jats:sup>-\/-<\/jats:sup> mouse model. The results showed that the absence of IRF7 made mice more susceptible to RABV, because IRF7 restricted the replication of RABV in the early stage of infection. IRF7 deficiency affected the recruitment of plasmacytoid dendritic cells to the draining lymph nodes (dLNs), reduced the production of type I IFN and expression of IFN-stimulated genes. Furthermore, we found that the ability to produce specific RABV-neutralizing antibody was impaired in IRF7<jats:sup>-\/-<\/jats:sup> mice. Consistently, IRF7 deficiency affected the recruitment of germinal-centre B cells to dLNs, and the generation of plasma cells and RABV-specific antibody secreting cells. Moreover, the absence of IRF7 downregulated the induction of IFN-\u03b3 and reduced type 1 T helper cell (Th1)-dependent antibody production. Collectively, our findings demonstrate that IRF7 promotes humoral immune responses and compromises the pathogenicity of RABV in a mouse model.<\/jats:p>","DOI":"10.1099\/jgv.0.001665","type":"journal-article","created":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T23:30:20Z","timestamp":1634599820000},"source":"Crossref","is-referenced-by-count":5,"title":["The role of interferon regulatory factor 7 in the pathogenicity and immunogenicity of rabies virus in a mouse model"],"prefix":"10.1099","volume":"102","author":[{"given":"Caiqian","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Preventive Veterinary Medicine of Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, PR China"},{"name":"State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, PR 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