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These molecular virus-host interactions play a crucial role in determining the success of DENV infection. Deciphering such interactions is thus paramount to understanding viral fitness in its natural hosts. While DENV-mammalian host interactions have been extensively studied, not much has been done to characterize DENV-mosquito host interactions despite its importance in controlling DENV transmission. Here, to provide a snapshot of our current understanding of DENV-mosquito interactions, we review the literature that identified host factors and cellular processes related to DENV infection in its mosquito vectors, <jats:italic>Aedes aegypti<\/jats:italic> and <jats:italic>Aedes albopictus<\/jats:italic>, with a particular focus on DENV-mosquito omics studies. This knowledge provides fundamental insights into the DENV life cycle, and could contribute to the development of novel antiviral strategies.<\/jats:p>","DOI":"10.1099\/jgv.0.001693","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T12:15:35Z","timestamp":1638274535000},"source":"Crossref","is-referenced-by-count":13,"title":["Revisiting dengue virus-mosquito interactions: molecular insights into viral fitness"],"prefix":"10.1099","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3001-0528","authenticated-orcid":false,"given":"Tanamas","family":"Siriphanitchakorn","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, National University of Singapore, 117558 Singapore, Singapore"},{"name":"Programme in Emerging Infectious Diseases, Duke-NUS Medical School, 169857 Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6100-3251","authenticated-orcid":false,"given":"R. 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