{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:32:47Z","timestamp":1791379967109,"version":"4.3.3"},"reference-count":47,"publisher":"Microbiology Society","issue":"11","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"crossref","award":["DE180100484"],"award-info":[{"award-number":["DE180100484"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"crossref","award":["DP180100520"],"award-info":[{"award-number":["DP180100520"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,28]]},"abstract":"<jats:p>\n                    The devil facial tumour disease (DFTD) has led to a massive decline in the wild Tasmanian devil (\n                    <jats:italic>Sarcophilus harrisii<\/jats:italic>\n                    ) population. The disease is caused by two independent devil facial tumours (DFT1 and DFT2). These transmissible cancers have a mortality rate of nearly 100\u200a%. An adenoviral vector-based vaccine has been proposed as a conservation strategy for the Tasmanian devil. This study aimed to determine if a human adenovirus serotype 5 could express functional transgenes in devil cells. As DFT1 cells do not constitutively express major histocompatibility complex class I (MHC-I), we developed a replication-deficient adenoviral vector that encodes devil interferon gamma (IFN-\u03b3) fused to a fluorescent protein reporter. Our results show that adenoviral-expressed IFN-\u03b3 was able to stimulate upregulation of beta-2 microglobulin, a component of MHC-I, on DFT1, DFT2 and devil fibroblast cell lines. This work suggests that human adenoviruses can serve as a vaccine platform for devils and potentially other marsupials.\n                  <\/jats:p>","DOI":"10.1099\/jgv.0.001812","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T08:16:57Z","timestamp":1668586617000},"source":"Crossref","is-referenced-by-count":13,"title":["A human adenovirus encoding IFN-\u03b3 can transduce Tasmanian devil facial tumour cells and upregulate MHC-I"],"prefix":"10.1099","volume":"103","author":[{"given":"Ahab N.","family":"Kayigwe","sequence":"first","affiliation":[{"name":"Department of Science and Laboratory Technology, Dar es Salaam Institute of Technology, Bibititi and Morogoro Rd Junction, P. O. Box 2958, Dar-es-salaam, Tanzania"},{"name":"Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, TAS, 7000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"M. 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