{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:07:55Z","timestamp":1747181275192,"version":"3.40.5"},"reference-count":47,"publisher":"Microbiology Society","issue":"1","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["1140169"],"award-info":[{"award-number":["1140169"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"crossref","award":["DP190101851"],"award-info":[{"award-number":["DP190101851"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Queensland Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,25]]},"abstract":"<jats:p>Host control of mouse cytomegalovirus (MCMV) infection of MHCII<jats:sup>-<\/jats:sup> salivary gland acinar cells is mediated by CD4<jats:sup>+<\/jats:sup> T cells, but how they protect is unclear. Here, we show CD4<jats:sup>+<\/jats:sup> T cells control MCMV indirectly in the salivary gland, via IFN\u03b3 engagement with uninfected, but antigen<jats:sup>+<\/jats:sup> MHCII<jats:sup>+<\/jats:sup> APC and recruitment of NK cells to infected cell foci. This immune mechanism renders direct contact of CD4<jats:sup>+<\/jats:sup> T cells with infected cells unnecessary and may represent a host strategy to overcome viral immune evasion.<\/jats:p>","DOI":"10.1099\/jgv.0.001956","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T16:17:10Z","timestamp":1706199430000},"source":"Crossref","is-referenced-by-count":1,"title":["Indirect CD4+ T cell protection against persistent MCMV infection by NK cells requires IFN\u03b3"],"prefix":"10.1099","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5838-1024","authenticated-orcid":false,"given":"Wanxiaojie","family":"Xie","sequence":"first","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8889-0439","authenticated-orcid":false,"given":"Kimberley","family":"Bruce","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3520-5060","authenticated-orcid":false,"given":"Philip G.","family":"Stevenson","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7214-2767","authenticated-orcid":false,"given":"Helen E.","family":"Farrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00582-z"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit629"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00787-06"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00202"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1038\/nri3152"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2010.02.008"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052246"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02128-16"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1038\/35103104"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00019"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.3390\/v9090249"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1038\/12478"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.76.21.10929-10941.2002"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.1.167"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00251-16"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01264-17"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.09.082"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.8.4200-4202.2006"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2015.03.010"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02123-15"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006905"},{"key":"R22","first-page":"507","article-title":"Class II MHC antigens in the rat digestive system. Normal distribution and induced expression after interferon-gamma treatment in vivo","volume":"68","author":"Steiniger","year":"1989","journal-title":"Immunology"},{"key":"R23","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00077-22","article-title":"Cd4(+) T cells control murine cytomegalovirus infection indirectly","volume":"96","author":"Xie","year":"2022","journal-title":"J Virol"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.66.4.1977-1984.1992"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1993.1591"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002214"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1038\/ni1304"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10121531"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-008-0077-2"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062648"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300910"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00693-21"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201745553"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(07)96002-2"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.64.11.5457-5464.1990"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-75203-5_5"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.14.7536-7544.2004"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.3119"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005323"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-014-0441-9"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-015-0869-7"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.8.4279"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0796-1"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.01.004"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.147.3.781"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.6.3716"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00687"}],"container-title":["Journal of General Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jgv\/10.1099\/jgv.0.001956?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T16:17:15Z","timestamp":1706199435000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jgv\/10.1099\/jgv.0.001956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,25]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,25]]}},"URL":"https:\/\/doi.org\/10.1099\/jgv.0.001956","relation":{},"ISSN":["0022-1317","1465-2099"],"issn-type":[{"type":"print","value":"0022-1317"},{"type":"electronic","value":"1465-2099"}],"subject":[],"published":{"date-parts":[[2024,1,25]]}}}