{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:41:10Z","timestamp":1791848470191,"version":"4.3.4"},"reference-count":15,"publisher":"Microbiology Society","issue":"6","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Research Council","award":["MC_UU_00034\/3"],"award-info":[{"award-number":["MC_UU_00034\/3"]}]},{"name":"Medical Research Council","award":["MC_UU_00034\/2"],"award-info":[{"award-number":["MC_UU_00034\/2"]}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"crossref","award":["BB\/X011607\/1"],"award-info":[{"award-number":["BB\/X011607\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,11]]},"abstract":"<jats:p>Increased human-to-human transmission of monkeypox virus (MPXV) is cause for concern, and antibodies directed against vaccinia virus (VACV) are known to confer cross-protection against Mpox. We used 430 serum samples derived from the Scottish patient population to investigate antibody-mediated cross-neutralization against MPXV. By combining electrochemiluminescence immunoassays with live-virus neutralization assays, we show that people born when smallpox vaccination was routinely offered in the United Kingdom have increased levels of antibodies that cross-neutralize MPXV. Our results suggest that age is a risk factor of Mpox infection, and people born after 1971 are at higher risk of infection upon exposure.<\/jats:p>","DOI":"10.1099\/jgv.0.001999","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T12:16:58Z","timestamp":1718108218000},"source":"Crossref","is-referenced-by-count":9,"title":["Smallpox vaccination campaigns resulted in age-associated population cross-immunity against monkeypox virus"],"prefix":"10.1099","volume":"105","author":[{"given":"Kieran","family":"Dee","sequence":"first","affiliation":[{"name":"MRC-University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Manali","sequence":"additional","affiliation":[{"name":"MRC-University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Bissett","sequence":"additional","affiliation":[{"name":"MRC-University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Bone","sequence":"additional","affiliation":[{"name":"MRC-University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Callum","family":"Magill","sequence":"additional","affiliation":[{"name":"MRC-University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Davis","sequence":"additional","affiliation":[{"name":"MRC-University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Willett","sequence":"additional","affiliation":[{"name":"MRC-University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4352-394X","authenticated-orcid":false,"given":"Pablo R.","family":"Murcia","sequence":"additional","affiliation":[{"name":"MRC-University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2023.02.003"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.08.026"},{"key":"R3","article-title":"Multi-country outbreak of mpox, External situation report#27 \u2013 14 August 2023","year":"2023"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.7765\/9781526126764"},{"key":"R5","first-page":"1","article-title":"Evaluation of smallpox vaccination policy","volume":"57","author":"Arita","year":"1979","journal-title":"Bull World Health Organ"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiac409"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81265-0"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.12.7845-7851.2005"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02229-3"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.049"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1038\/nm917"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28643"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48180-w"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02090-w"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2023.04.015"}],"container-title":["Journal of General Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jgv\/10.1099\/jgv.0.001999?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T12:17:05Z","timestamp":1718108225000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jgv\/10.1099\/jgv.0.001999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,11]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6,11]]}},"URL":"https:\/\/doi.org\/10.1099\/jgv.0.001999","relation":{},"ISSN":["0022-1317","1465-2099"],"issn-type":[{"value":"0022-1317","type":"print"},{"value":"1465-2099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,11]]}}}