{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:34:24Z","timestamp":1767897264046,"version":"3.49.0"},"reference-count":78,"publisher":"Microbiology Society","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011310","name":"Rural and Environment Science and Analytical Services Division","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011310","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,8]]},"abstract":"<jats:p>\n                    Ovine herpesvirus 1 (OvHV-1) was first identified over 50\u2009years ago in sheep with ovine pulmonary adenocarcinoma (OPA). An aetiological role in OPA was later ruled out and OvHV-1 was found to be a common infection in sheep in several countries. Here, we report the sequence and annotation of the complete OvHV-1 genome. The virus has a similar genomic architecture to members of the\n                    <jats:italic>Macavirus<\/jats:italic>\n                    genus of the subfamily\n                    <jats:italic>Gammaherpesvirinae<\/jats:italic>\n                    and is most closely related to bovine gammaherpesvirus 6 (BoGHV6). The OvHV-1 genome comprises a 144,637 bp unique region predicted to encode at least 74 proteins bounded by multiple copies of a 699 bp GC-rich repetitive terminal repeat. Predicted genes include 61 ORFs conserved among all gammaherpesviruses, and 12 genes present only in macavirus genomes, including a homologue of ovine IL-10, previously reported only in ovine gammaherpesvirus 2, and an ornithine decarboxylase, previously described only in BoGHV6. A further gene appears unique to OvHV-1 among macaviruses, encoding a viral-FLIP (FLICE-like inhibitory protein), similar to those found in some other gammaherpesviruses. Notably, several macavirus genes previously predicted in BoGHV6 are defective in OvHV-1. The availability of the genome sequence of OvHV-1 will facilitate studies on its relationship to other macaviruses and its role, if any, in disease.\n                  <\/jats:p>","DOI":"10.1099\/jgv.0.002192","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T13:17:19Z","timestamp":1767878239000},"source":"Crossref","is-referenced-by-count":0,"title":["Genome sequence and annotation of ovine herpesvirus 1"],"prefix":"10.1099","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5599-3933","authenticated-orcid":false,"given":"Paolo","family":"Ribeca","sequence":"first","affiliation":[{"name":"Biomathematics and Statistics Scotland, The King\u2019s Buildings, Edinburgh, UK"},{"name":"UK Health Security Agency, 61 Colindale Avenue, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Dewar","sequence":"additional","affiliation":[{"name":"Moredun Research Institute, Pentlands Science Park, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0580-3011","authenticated-orcid":false,"given":"Michelle L.","family":"McNab","sequence":"additional","affiliation":[{"name":"Moredun Research Institute, Pentlands Science Park, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3995-5472","authenticated-orcid":false,"given":"Chris","family":"Cousens","sequence":"additional","affiliation":[{"name":"Moredun Research Institute, Pentlands Science Park, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1951-3215","authenticated-orcid":false,"given":"George C.","family":"Russell","sequence":"additional","affiliation":[{"name":"Moredun Research Institute, Pentlands Science Park, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9160-0770","authenticated-orcid":false,"given":"David J.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Moredun Research Institute, Pentlands Science Park, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/0147-9571(79)90019-5"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(69)90061-9"},{"key":"R3","first-page":"165","article-title":"Characteristics of an ovine herpesvirus associated with pulmonary adenomatosis (Jaagsiekte) in sheep","volume":"40","author":"de Villiers","year":"1975","journal-title":"S Afr J Med Sci"},{"key":"R4","first-page":"528","article-title":"Morphologic study of virus-infected lung cell cultures from sheep pulmonary adenomatosis (Jaagsiekte)","volume":"26","author":"Malmquist","year":"1972","journal-title":"Lab Invest"},{"key":"R5","first-page":"31","article-title":"Sheep pulmonary adenomatosis (SPA) in Crna Gora. 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