{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T08:29:39Z","timestamp":1770366579021,"version":"3.49.0"},"reference-count":28,"publisher":"Microbiology Society","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"crossref","award":["JP223fa627001"],"award-info":[{"award-number":["JP223fa627001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"crossref","award":["25wm0325063h0003"],"award-info":[{"award-number":["25wm0325063h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP23K21381"],"award-info":[{"award-number":["JP23K21381"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP23K27417"],"award-info":[{"award-number":["JP23K27417"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,5]]},"abstract":"<jats:p>\n                    Feline morbillivirus (FeMV), first identified in 2012, is a member of the genus\n                    <jats:italic>Morbillivirus<\/jats:italic>\n                    . Like other morbilliviruses, FeMV utilizes signalling lymphocytic activation molecule (CD150 or SLAMF1) as a cellular receptor; however, it is genetically distinct and notable for its unique tissue tropism, particularly its ability to establish persistent infections in the feline kidney. In this study, we established a plaque assay system using Vero cells stably expressing feline SLAMF1 and quantitatively evaluated neutralizing antibodies against FeMV in the sera of domestic cats. The results showed that FeMV-infected feline sera contained exceptionally high titres of FeMV-specific neutralizing antibodies, often far exceeding those observed in animals infected with other morbilliviruses. Importantly, sera with high neutralizing activity against FeMV exhibited undetectable cross-neutralizing activity against other morbilliviruses. In contrast, significant cross-neutralization was observed among non-FeMV morbilliviruses. These findings indicate that FeMV surface glycoproteins are antigenically distinct, underscoring the immunological uniqueness of FeMV. Moreover, while feline SLAMF1 functions as a receptor for various morbilliviruses, FeMV utilized only feline SLAMF1. These data suggest that the receptor-binding domain of FeMV is uniquely adapted to the feline SLAMF1. This study offers valuable tools and insights for FeMV research, advancing our understanding of its antigenicity and host receptor usage.\n                  <\/jats:p>","DOI":"10.1099\/jgv.0.002207","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T17:16:32Z","timestamp":1770311792000},"source":"Crossref","is-referenced-by-count":0,"title":["Feline morbillivirus elicits robust neutralizing antibodies in domestic cats without cross-neutralizing activities against canonical morbilliviruses"],"prefix":"10.1099","volume":"107","author":[{"given":"Kaede","family":"Tashiro","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine, Laboratory of Preventive Veterinary Medicine and Animal Health, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa 252-0880, Japan"},{"name":"Department of Molecular Virology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Bunkyo-ku, Tokyo 113-8510, Japan"},{"name":"Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyotaka","family":"Konishi","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Sil","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku-ku, Tokyo 162-8640, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumu","family":"Hyodo","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Seki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Viruses, National Institute of Infectious Diseases, Japan Institute for Health Security, Musashimurayama, Tokyo 208-0011, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kitai","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Akahori","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minglin","family":"Ju","sequence":"additional","affiliation":[{"name":"Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Katoh","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Segawa","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Laboratory of Preventive Veterinary Medicine and Animal Health, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa 252-0880, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Shirogane","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Bunkyo-ku, Tokyo 113-8510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Itou","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Laboratory of Preventive Veterinary Medicine and Animal Health, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa 252-0880, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Furuya","sequence":"additional","affiliation":[{"name":"Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, National Institute of Infectious Diseases, Japan Institute for Health Security, Shinjuku-ku, Tokyo 162-8640, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8194-7727","authenticated-orcid":false,"given":"Makoto","family":"Takeda","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan"},{"name":"Pandemic Preparedness, Infection and Advanced Research Center, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119972109"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.3390\/v14071503"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2209405119"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.13030"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.3390\/v11070606"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2020.03.003"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(88)90072-0"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-023-01380-4"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1038\/nature10639"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002240"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2025.115216"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.17.11547-11551.2005"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.03.035"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03676-13"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-025-02005-8"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.9.4399-4401.2001"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.18.9943-9950.2003"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12788"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1012990"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.065029-0"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2012.10.033"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-016-0853-y"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.3354\/dao03751"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.13207"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.14278"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050955"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1177\/0300985820948820"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00702-13"}],"container-title":["Journal of General Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jgv\/10.1099\/jgv.0.002207?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T17:16:33Z","timestamp":1770311793000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jgv\/10.1099\/jgv.0.002207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,5]]}},"URL":"https:\/\/doi.org\/10.1099\/jgv.0.002207","relation":{},"ISSN":["0022-1317","1465-2099"],"issn-type":[{"value":"0022-1317","type":"print"},{"value":"1465-2099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]}}}