{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:09:09Z","timestamp":1778857749300,"version":"3.51.4"},"reference-count":45,"publisher":"Microbiology Society","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"MRC CVR Preparedness Platform Award","award":["MC_UU_00034\/6"],"award-info":[{"award-number":["MC_UU_00034\/6"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:p>Feline coronavirus (FCoV) is a ubiquitous virus of cats, with highly variable seroprevalence, ranging between 4 and 95%\u2009worldwide in the domestic cat population. It is the causative agent of feline infectious peritonitis (FIP), a disease which, prior to the recent introduction of effective antiviral drug treatments, was invariably fatal. The recent outbreak of FIP, originating in Cyprus and caused by the novel recombinant FCoV-23, highlighted the need to increase understanding of the serological response to FCoV. This study aimed to characterize the serological response to the virus and to assess cross-neutralization of type II FCoV subtypes as well as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In serum samples of 1117 UK cats collected between 2020 and 2023, we detected an FCoV-II neutralizing antibody (nAb) seroprevalence of 13.6% and an overall seroprevalence of 59.5%; commonly cited risk factors (sex, age and breed) did not significantly impact the nAb seroprevalence nor nAb titre against FCoV-II. Antibodies against subtypes FIPV-79\u20131146 and FIPV-DF-2 were found to be cross-reactive and additionally neutralized both isoforms of FCoV-23. In contrast, no cross-neutralization was observed against SARS-CoV-2. Overall, these results highlight that although FCoV infection offers effective cross-protection between FCoV strains and subtypes, this does not extend to betacoronaviruses.<\/jats:p>","DOI":"10.1099\/jgv.0.002270","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:16:49Z","timestamp":1778854609000},"source":"Crossref","is-referenced-by-count":0,"title":["Serological response to feline coronavirus in the UK domestic cat population"],"prefix":"10.1099","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9553-3525","authenticated-orcid":false,"given":"Hagar","family":"Sasvari","sequence":"first","affiliation":[{"name":"MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Sherry","sequence":"additional","affiliation":[{"name":"MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, 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