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Viral infections are known as potent modulators of NAD\n                    <jats:sup>+<\/jats:sup>\n                    metabolism, with pathogens such as SARS-CoV-2, influenza A virus, Zika virus, herpes simplex virus and human immunodeficiency virus altering NAD\n                    <jats:sup>+<\/jats:sup>\n                    biosynthesis and consumption to benefit their persistence and replication. In this review, we summarize the current understanding of NAD\n                    <jats:sup>+<\/jats:sup>\n                    metabolism and its regulatory enzymes: sirtuins, poly (ADP-ribose) polymerases and CD38\/CD157. We then discuss the interplay between NAD\n                    <jats:sup>+<\/jats:sup>\n                    homeostasis and virus infection. 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