{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:59:10Z","timestamp":1781661550085,"version":"3.54.5"},"reference-count":14,"publisher":"Microbiology Society","issue":"8","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:p>\n                  <jats:bold>Objectives.<\/jats:bold>\n                  <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.9258\" xlink:type=\"simple\">Elizabethkingia meningoseptica<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> is a multi-drug-resistant organism that is associated with high mortality and morbidity in newborn and immunocompromised patients. This study aimed to identify the best antimicrobial therapy for treating this infection.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods.<\/jats:bold> A retrospective descriptive study was conducted from 2010 to 2017 in a tertiary paediatric hospital in Singapore. Paediatric patients aged 0 to 18\u2009years old with a positive culture for <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.9258\" xlink:type=\"simple\">E. meningoseptica<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> from any sterile site were identified from the hospital laboratory database. The data collected included clinical characteristics, antimicrobial susceptibility and treatment, and clinical outcomes.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results.<\/jats:bold> Thirteen cases were identified in this study. Combination therapy with piperacillin\/tazobactam and trimethoprim\/sulfamethoxazole or a fluoroquinolone resulted in a cure rate of 81.8 \u200a%. The mortality rate was 15.4 \u200a% and neurological morbidity in patients with bacteraemia and meningitis remained high (75\u2009%).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions.<\/jats:bold> Treatment with combination therapy of piperacillin\/tazobactam and trimethoprim\/sulfamethoxazole or a fluroquinolone was effective in this study, with low mortality rates being observed.<\/jats:p>","DOI":"10.1099\/jmm.0.001021","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T15:12:57Z","timestamp":1560525177000},"page":"1167-1172","source":"Crossref","is-referenced-by-count":24,"title":["Invasive paediatric Elizabethkingia meningoseptica infections are best treated with a combination of piperacillin\/tazobactam and trimethoprim\/sulfamethoxazole or fluoroquinolone"],"prefix":"10.1099","volume":"68","author":[{"given":"J. C.","family":"Chan","sequence":"first","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"Department of Paediatrics, KK Women\u2019s and Children\u2019s Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Y.","family":"Chong","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore"},{"name":"Duke-National University of Singapore Medical School, Singapore"},{"name":"Department of Paediatrics, Infectious Disease Service, KK Women\u2019s and Children\u2019s Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. C.","family":"Thoon","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"Department of Paediatrics, Infectious Disease Service, KK Women\u2019s and Children\u2019s Hospital, Singapore"},{"name":"Duke-National University of Singapore Medical School, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. W. S.","family":"Tee","sequence":"additional","affiliation":[{"name":"Duke-National University of Singapore Medical School, Singapore"},{"name":"Department of Pathology and Laboratory Medicine, National University Hospital, Singapore"},{"name":"Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Maiwald","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"Department of Pathology and Laboratory Medicine, KK Women\u2019s and Children\u2019s Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C. M.","family":"Lam","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"Duke-National University of Singapore Medical School, Singapore"},{"name":"Department of Paediatric Subspecialties, Haematology\/Oncology Service, KK Women\u2019s and Children\u2019s Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"Duke-National University of Singapore Medical School, Singapore"},{"name":"Department of Paediatric Subspecialties, Haematology\/Oncology Service, KK Women\u2019s and Children\u2019s Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Chandran","sequence":"additional","affiliation":[{"name":"Duke-National University of Singapore Medical School, Singapore"},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore"},{"name":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"Department of Neonatology, KK Women\u2019s and Children\u2019s Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. F.","family":"Yung","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Infectious Disease Service, KK Women\u2019s and Children\u2019s Hospital, Singapore"},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. W. 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